T3/rT3-ratio is associated with insulin resistance independent of TSH

[Guest guest]

http://www.ncbi.nlm.nih.gov/pubmed/21104580

Abstract

Thyroid dysfunction has been shown to be associated with insulin resistance

(IR). This may involve peripheral thyroid hormone metabolism, which is assumed

to be reflected by the ratio triiodothyronine/reverse triiodothyronine

(T3/rT3-ratio). To explore a potential association between the T3/rT3-ratio and

IR we investigated pairs which differed in IR, but were matched by sex, age,

body mass index (BMI), and thyroid stimulating hormone (TSH). For this purpose,

matched pair analyses were embedded into a cross sectional study group. 22 pairs

were matched from either the first or the third tertile of HOMA%S of a cohort of

353 euthyroid subjects with normal glucose metabolism who did not take any

medication. The T3/rT3-ratio was compared in the matched pairs. The T3/rT3-ratio

was significantly increased in the insulin resistant subjects compared to their

insulin sensitive partners (8.78 ± 0.47 vs. 7.33 ± 0.33, p=0.019). Furthermore

the T3/rT3-ratio was lower in men compared to women (p for the within-subject

effect=0.046) both in the insulin sensitive and the insulin resistant subjects.

Here we show that the T3/rT3-ratio, which is supposed to reflect the tissue

thyroid hormone metabolism, is significantly increased in insulin resistant

subjects. This further supports a link between thyroid function and IR.

[Guest guest]

Hi

Nice info.

Insulin resistance will cause less glucose to flow into the cells and thus

reduce ATP generation. It will hamper thyroid hormone activity in much the same

way that actual diabetes or low cortisol can. Poor diet or digestive system

issues can have exactly the same impact.

Low glucose in the cells and then low ATP generation will tend to limit the

processing of thyroid hormone within the tissues - simply because the T3 and T4

cannot be equally matched by sufficient ATP. So, the question might be " which is

the chicken and which is the egg? " Does the insulin resistance cause the thyroid

dysfunction or the thyroid dysfunction cause the insulin resistance or can they

both occur?

So, it can be something of a vicious circle until enough of the right types of

thyroid hormones are present and even then the return to full health may be a

long road once many areas of metabolism have been disrupted.

Author of: Recovering with T3 My Journey from Hypothyroidism to Good Health

Using the T3 Thyroid hormone.

My website: recoveringwitht3.com

>

> http://www.ncbi.nlm.nih.gov/pubmed/21104580

>

> Abstract

>

> Thyroid dysfunction has been shown to be associated with insulin resistance

(IR). This may involve peripheral thyroid hormone metabolism, which is assumed

to be reflected by

[Guest guest]

Hi

I think it's quite recent research. It's probably not news to some people

though.

I have insulin resistance/metabolic syndrome, which i'm trying to reverse.

It's not easy.

Please if you can offer your thoughts generally on this topic i'd be grateful.

I am on Erfa thyroid and have some improvement from it.

One of my problems though is over eating carbs, and sometimes I have little

control over these impulses. Googling this I found this information, which

leads me to believe it's thyroid related > i say this because when I take more

thyroid the impulses are less. There's a theory that more glucose is needed by

the cells so a binge will do this because of all that sugar and all that insulin

driving it in to the cells. Of note is that one binge on carbs will 'sort it

out' - ie, it's not a repeat thing per day.

http://thyroid.about.com/gi/dynamic/offsite.htm?site=http://www.thyroid%2Dinfo.c\

om/articles/ray%2Dpeat.htm

Shomon: You have written that for some people, there is a problem

converting T4 to T3, but that diet can help. You recommend a piece of fruit or

juice or milk between meals, plus adequate protein, can help the liver produce

the hormone. Can you explain a bit more about this idea and how it works?

Dr. Ray Peat: The amount of glucose in liver cells regulates the enzyme that

converts T4 to T3. This means that hypoglycemia or diabetes (in which glucose

doesn't enter cells efficiently) will cause hypothyroidism, when T4 can't be

converted into T3. When a person is fasting, at first the liver's glycogen

stores will provide glucose to maintain T3 production. When the glycogen is

depleted, the body resorts to the dissolution of tissue to provide energy. The

mobilized fatty acids interfere with the use of glucose, and certain amino acids

suppress the thyroid gland. Eating carbohydrate (especially fruits) can allow

the liver to resume its production of T3.

http://www.criticalbench.com/overcoming_binge_eating.htm

What is a Binge?

A binge is not necessarily a form of weakness or will-power, but is associated

with an imbalance correlated with a low-caloric diet. Cutting calories below

one's BMR affects the thyroid. **The body's defense in correcting the imbalanced

thyroid takes place through binges, which makes the thyroid active once again.**

After a binge, an excess amount of calories has been ingested and out of guilt

and punishment the individual starves himself again. This type of behavior is a

form of yo-yo dieting that leads to weight gain. By cutting calories and then

binging, the body is put into starvation defense mode which damages the

metabolism and ultimately causes more fat storage.

Please can you offer any general thoughts or suggestions for helping with this

matter?

Thanks

Chris

>

> Hi

>

> Nice info.

>