RE: th1 th2 balance

[Guest guest]

It sounds as if you need the active thyroid hormone T3 and to

stop taking the mainly inactive hormone T4 Carly. However much you titrate the

T4 up or down, if it can't convert, your body is never going to be able to get

the T3 that every cell in the body and brain needs to make them function

Luv - Sheila

I am still unwell and extremely exhausted as my thryoid meds, although high in

blood, do not get through to the cells and are very low in urine tests. This

has been the major problem all along. Therefore I get toxic symps if high in

blood but if I lower the meds I get even more exhausted as then even less

thyroid gets ito cells making me even more hypothyroid... and tired.. Ahh

sigh!...

,___

[Guest guest]

Thanks shelia,

appreciate the reply. I have tried just t3 though and still same problem. Don't

think it's a conversion prob now, just the recepter prob. I can't get any higher

currently on my t3 dose, even if lower t4. I do believe t4 does also work for

me. I seem to be a complicated case. Looking into a few things tho.

Thanks again

carly x

> It sounds as if you need the active thyroid hormone T3 and to stop taking

> the mainly inactive hormone T4 Carly. However much you titrate the T4 up or

> down, if it can't convert, your body is never going to be able to get the T3

> that every cell in the body and brain needs to make them function

[Guest guest]

Have you ever researched T2 [sic]?

I looked into it a while back and some people were saying they thought it might

play some part in allowing the thyroid receptor to work? Sorry I cannot

remember the articles or exactly what was said. Some fibromyalgia patients have

reported that T2 helped them more than T3.

http://www.powermyself.com/product/SAN_T2_Xtreme_180_Caps_SAN-19 --- T2

have you ordered the vitamin A now?

as always discuss anything like taking T2 with your practitioner....

thyroid treatment/files/INFORMATION%20\

ABOUT%20T2%20AND%20T1/

" T2 5-Diiodotyrosine 50mcg

Description:

T2 is taken up by the cells and acts directly on the mitochondria. The T2 is

used to produce ATP. ATP is the fuel for our cells; it is the energy our cells

use to function. So you see, T2 is absolutely vital for the cells to function,

certain cells in the body depend on it.

If you take synthetic thyroid hormone you should add T2 to your daily regime.

If you are on a dessicated thyroid hormone additional T2 is not needed as

Dessicated thyroid hormone contains T2. If you are on T3 alone then T2 is a

must.

Extended Details

When patients are on T4 and or T3 do you always use some T2 as well?

Yes since most people are deficient in T2, the only way to get bio-identical

ratios of the hormones with replenishment therapy, is to give T2 as well.

Furthermore, taking T2 is particularly important where weight loss is required,

since unlike T3 and T4, T2 only affects the mitochondria of the cells, not the

nucleus, making it not only safer, but also treats obesity via a second distinct

mechanism of action - always a good thing.

Finally, theorectically at least, stimulation of the mitochondria by T2 may

help delay ageing, since mitochondrial energy diseases and subsequent cell death

is one of the current theories of ageing.

What dosage is required?

Dosage:

50mcg per day. Dosage Ratio of T4:T3:T2 is 4:1:2 (some say 4:1:1) e.g. 100mcg

T4: 25mcg T3: 50mcg T2.

What are the benefits of T2?

Elevates Basal Metabolic Rate by stimulation of the mitochondria

Fat loss (T2 is most active in BAT - Brown adipose tissue)

Increased energy

May help prevent energy (miochondrial) diseases

Does not suppress TSH as much as T4 or T3 (T2 suppresses TSH 13-100 times less

than T3 and T4 does)

What is the exact mechanism how T2 works differently to T4/T3?

T2 releases energy via a mitochondrial / ATP mechanism, not in the nucleus, by

inducing the transcription of genes that control energy metabolism (which is how

T3 and T4 works). There are a number of mechanisms whereby T2 increases

mitochondrial energy production rates, resulting in increased ATP levels. These

include:

An increased influx of CA++ into the mitochondria, with a resulting increase in

mitochondrial dehydrogenases.

This in turn would lead to an increase in reduced substrates available for

oxidation.

An increase in cytochrome oxidase activity has also been observed.

This would hasten the reduction of 02, speeding up respriation. These and a

number of other proposed mechanisms for the action of T2 are reviewed by Lannie

et al. (J Endocrinol Invest 2001 Dec:24(11):897-913 Control of energy metabolism

by iodothyronines.Lanni A, Moreno M, Lombardi A, de Lange P, Goglia F)

The net result is increases ATP, which releases its energy via the following

mechanisms;

Increased Na +/K+ATPase. This is the enzyme responsible for controlling the

NA/kpump, which regulates the relative intracellular and extracellular

concentrations of these ions, maintaining the normal transmembrane ion gradient.

Sestoft has estimated this effect may account for up to 10% of the increase ATP

usage (J Endocrinol Invest 2001 Dec; 24(11):897-913 Control of energy metabolism

by iodothyronines. Lanni A, Moreno M, Lombardi A, de Lange P, Goglia F)

Increased CA++-dependent ATPase. The intracellular concentration of calcium

must be kept lower than the extracellular concentration to maintain normal

cellular function ATP is required to pump out excess calcium. It has been

estimated that 10% of a cell's energy expenditure is used just to maintain CA++

homeostasis. (Endocrinology 2002 Feb;143 (2):504 -10 Are the effects of T3 on

resting metabolic rate in euthyroid rats entirely caused by T3 itself? Moreno

M, Lombardi A, Beneduce L, Silvestri E, Pinna G. Goglia F, Lanni A)

Substrate cycling. Hyperthyroidism induces a futile cycle of

lipogenesis/lipolysis in fat cells. The stored triglycerides are broken down

into free fatty acids and glycerol, then reformed back into triglycerides again.

This is an energy dependent process that utilises some of the excess ATP

produced in the hyperthyroid state. Futile cycling has been estimated to use

approximately 15% of the excess ATP created during hyperthyroidism. (Clin

Endocrinol (Oxf) 1980 Nov;13(5):489-506 Metabolic aspects of the calorigenic

effect of thyroid hormone in mammals. Sestoft L.)

Increased Heart Work. This puts perhaps the greatest single demand on ATP

usage, with increased heart rate and force of contraction accounting for up to

30% to 40% of ATP usage in hyperthyroidism (Annu Rev Nutr 1995;15;263-91

Thermogenesis and thyroid function. Freake HC, Oppenheimer JH.)

Is it necessary in the body?

The answer is yes, but it is not essential - you can live without it, but it's

not a good idea.

If people have a problem converting T4 to T3 would they have the same problem

converting T3 to T2?

Yes, which is why T2 should be taken.

How safe is T2?

T2 is safer than T3 and T4 because it does not affect the nucleus (DNA) of the

cells, only the mitochondria. Also T2 only minimally suppresses TSH. However,

negative feedback is a concern in the younger patient or using high doses and

doses should be cycled, using the lowest effective dose.

Would patients have to reduce their dosage of T4 and/or 3 when starting 2?

Theoretically, yes slightly. Practically, probably not.

Is T2 as important as T4/T3 in hypothyroidism?

No but very necessary for weight loss and energy.

At what dosage does T2 normally suppress TSH?

The studies are somewhat conflicting, but one thing seems to be prevalent

amongst them all. That is, TSH inhibition isn't nearly as severe with T2 as it

is with T3.

One study showed that T2 is 13% less inhibitory on TSH levels, as compared to

T3. In yet another study, T3 and T2 suppressed TSH to similar levels; however,

it took 15 mcg/100g body weight per day of T3 to accomplish this, while it took

200 mcg/100g body weight per day of T2 to accomplish the same thing. This means

it took about 13 times more T2 to exert the same effect on TSH as T3. One last

study. When researchers administered 100ug/Kg of T3 and 800-1600 ug/KG of T2

the following occurred: T3 rapidly decreased serum TSH levels within minimal

levels after 24 hours. Seventy-two hours after application TSH levels were

still significantly lower than control levels. As far as the T2, TSH levels

were transiently reduced and reached their lowest point at 24 hours and

increased afterwards. Basal levels were reached 72 hours after an application.

What they found after analysing the data was that there seemed to be a trend for

a dose-dependent (meaning, the higher the dosage the more TSH was inhibited)

suppression of TSH by T2 which did not reach statistical significance. That

means it didn't do it to a significant degree with the dosages used.

Furthermore, it appears as though it took 100 times more T2 than T3 to finally

exert the same amount of TSH inhibition. Even using 400 times more T2 than T3,

it appears that T3 only allows TSH to be inhibited to just a slight degree less

than T2.

T2 5-Diiodotyrosine 50mcg

Description:

T2 is taken up by the cells and acts directly on the mitochondria. The T2 is

used to produce ATP. ATP is the fuel for our cells; it is the energy our cells

use to function. So you see, T2 is absolutely vital for the cells to function,

certain cells in the body depend on it.

If you take synthetic thyroid hormone you should add T2 to your daily regime.

If you are on a dessicated thyroid hormone additional T2 is not needed as

Dessicated thyroid hormone contains T2. If you are on T3 alone then T2 is a

must.

Extended Details

When patients are on T4 and or T3 do you always use some T2 as well?

Yes since most people are deficient in T2, the only way to get bio-identical

ratios of the hormones with replenishment therapy, is to give T2 as well.

Furthermore, taking T2 is particularly important where weight loss is required,

since unlike T3 and T4, T2 only affects the mitochondria of the cells, not the

nucleus, making it not only safer, but also treats obesity via a second distinct

mechanism of action - always a good thing.

Finally, theorectically at least, stimulation of the mitochondria by T2 may

help delay ageing, since mitochondrial energy diseases and subsequent cell death

is one of the current theories of ageing.

What dosage is required?

Dosage:

50mcg per day. Dosage Ratio of T4:T3:T2 is 4:1:2 (some say 4:1:1) e.g. 100mcg

T4: 25mcg T3: 50mcg T2.

What are the benefits of T2?

Elevates Basal Metabolic Rate by stimulation of the mitochondria

Fat loss (T2 is most active in BAT - Brown adipose tissue)

Increased energy

May help prevent energy (miochondrial) diseases

Does not suppress TSH as much as T4 or T3 (T2 suppresses TSH 13-100 times less

than T3 and T4 does)

What is the exact mechanism how T2 works differently to T4/T3?

T2 releases energy via a mitochondrial / ATP mechanism, not in the nucleus, by

inducing the transcription of genes that control energy metabolism (which is how

T3 and T4 works). There are a number of mechanisms whereby T2 increases

mitochondrial energy production rates, resulting in increased ATP levels. These

include:

An increased influx of CA++ into the mitochondria, with a resulting increase in

mitochondrial dehydrogenases.

This in turn would lead to an increase in reduced substrates available for

oxidation.

An increase in cytochrome oxidase activity has also been observed.

This would hasten the reduction of 02, speeding up respriation. These and a

number of other proposed mechanisms for the action of T2 are reviewed by Lannie

et al. (J Endocrinol Invest 2001 Dec:24(11):897-913 Control of energy metabolism

by iodothyronines.Lanni A, Moreno M, Lombardi A, de Lange P, Goglia F)

The net result is increases ATP, which releases its energy via the following

mechanisms;

Increased Na +/K+ATPase. This is the enzyme responsible for controlling the

NA/kpump, which regulates the relative intracellular and extracellular

concentrations of these ions, maintaining the normal transmembrane ion gradient.

Sestoft has estimated this effect may account for up to 10% of the increase ATP

usage (J Endocrinol Invest 2001 Dec; 24(11):897-913 Control of energy metabolism

by iodothyronines. Lanni A, Moreno M, Lombardi A, de Lange P, Goglia F)

Increased CA++-dependent ATPase. The intracellular concentration of calcium

must be kept lower than the extracellular concentration to maintain normal

cellular function ATP is required to pump out excess calcium. It has been

estimated that 10% of a cell's energy expenditure is used just to maintain CA++

homeostasis. (Endocrinology 2002 Feb;143 (2):504 -10 Are the effects of T3 on

resting metabolic rate in euthyroid rats entirely caused by T3 itself? Moreno

M, Lombardi A, Beneduce L, Silvestri E, Pinna G. Goglia F, Lanni A)

Substrate cycling. Hyperthyroidism induces a futile cycle of

lipogenesis/lipolysis in fat cells. The stored triglycerides are broken down

into free fatty acids and glycerol, then reformed back into triglycerides again.

This is an energy dependent process that utilises some of the excess ATP

produced in the hyperthyroid state. Futile cycling has been estimated to use

approximately 15% of the excess ATP created during hyperthyroidism. (Clin

Endocrinol (Oxf) 1980 Nov;13(5):489-506 Metabolic aspects of the calorigenic

effect of thyroid hormone in mammals. Sestoft L.)

Increased Heart Work. This puts perhaps the greatest single demand on ATP

usage, with increased heart rate and force of contraction accounting for up to

30% to 40% of ATP usage in hyperthyroidism (Annu Rev Nutr 1995;15;263-91

Thermogenesis and thyroid function. Freake HC, Oppenheimer JH.)

Is it necessary in the body?

The answer is yes, but it is not essential - you can live without it, but it's

not a good idea.

If people have a problem converting T4 to T3 would they have the same problem

converting T3 to T2?

Yes, which is why T2 should be taken.

How safe is T2?

T2 is safer than T3 and T4 because it does not affect the nucleus (DNA) of the

cells, only the mitochondria. Also T2 only minimally suppresses TSH. However,

negative feedback is a concern in the younger patient or using high doses and

doses should be cycled, using the lowest effective dose.

Would patients have to reduce their dosage of T4 and/or 3 when starting 2?

Theoretically, yes slightly. Practically, probably not.

Is T2 as important as T4/T3 in hypothyroidism?

No but very necessary for weight loss and energy.

At what dosage does T2 normally suppress TSH?

The studies are somewhat conflicting, but one thing seems to be prevalent

amongst them all. That is, TSH inhibition isn't nearly as severe with T2 as it

is with T3.

One study showed that T2 is 13% less inhibitory on TSH levels, as compared to

T3. In yet another study, T3 and T2 suppressed TSH to similar levels; however,

it took 15 mcg/100g body weight per day of T3 to accomplish this, while it took

200 mcg/100g body weight per day of T2 to accomplish the same thing. This means

it took about 13 times more T2 to exert the same effect on TSH as T3. One last

study. When researchers administered 100ug/Kg of T3 and 800-1600 ug/KG of T2

the following occurred: T3 rapidly decreased serum TSH levels within minimal

levels after 24 hours. Seventy-two hours after application TSH levels were

still significantly lower than control levels. As far as the T2, TSH levels

were transiently reduced and reached their lowest point at 24 hours and

increased afterwards. Basal levels were reached 72 hours after an application.

What they found after analysing the data was that there seemed to be a trend for

a dose-dependent (meaning, the higher the dosage the more TSH was inhibited)

suppression of TSH by T2 which did not reach statistical significance. That

means it didn't do it to a significant degree with the dosages used.

Furthermore, it appears as though it took 100 times more T2 than T3 to finally

exert the same amount of TSH inhibition. Even using 400 times more T2 than T3,

it appears that T3 only allows TSH to be inhibited to just a slight degree less

than T2. "

[Guest guest]

Hi Carly - TH1/TH2 Testing is very expensive - about £300. In the UK there is

True Health Labs - check out their website.

I had over 1000 TPOabs a couple of months ago and researched this as I believe

its important to get deeper into the cause of what`s attacking the thyroid and

why. I found out a lot about the TH1/TH2 being kept in balance, but there`s no

way I could afford to have a proper test. So I worked it out by guessing and

trial and error. To begin with I knew I was not a `reactive histamine` type

person so this led me to think I may be TH1 dominant. I then set about

compiling a list of foods and drinks that I should avoid and a list that I

should add. Yes, I did feel better on Green Tea etc. So I`ve stuck with that

and am still feeling lots better. To confirm it I really should try ingesting

something like Echinacea and see if I react badly as this is a TH1 enhancer, but

I haven`t got the nerve to make myself bad at the moment. I`ve always wondered

why I feel bad after taking Vitamin C and apparently a lot of the immune system

boosters have a detrimental affect because they are actually stimulating the TH1

side of the immune system - its fine if you are TH2 dominant obviously.

Another thing - when I had my blood test done, I had been under extreme stress,

so this could have made things worse than they are normally, so I am more

conscious of not involving myself in any stressful situations.

If you do decide to go for the test, let us all know how you get on.

Jane

>

> > Anyway, am thinking this is an area to explore? HAs anyone done this? Are

there any UK docs knowledgeable of this? Also is there anywhere to test which

side I am as dont want to just assume even though some people may be able to. I

want to know for sure if am th1 or th2 dominant? WOuld an immunnogist be

familiar with this do you think? would be great to work with an expert on this.

>

> Basically anyone found this has helped/worked along side normal thyroid

medication etc.??? Or anyone working with a UK doc? Or had uk testing done?

>

> Would be really interested to hear from you...

> Thank very much. Hope everyone doing ok snd thank you in advance for any help.

> Carly x

>

[Guest guest]

Carly, you should check that you have recently had specific

vitamins and minerals tested. I know that I keep going on about these but it is

absolutely essential when the thyroid hormone doesn't seem to be doing the job

it should that you check to find out whether any of these are low in the

reference range. These are iron, transferrin saturation%, ferritin, vitamin

B12, vitamin D3, magnesium, folate, copper and zinc. When you get these results,

post them on the forum together with the reference range for each of the tests

done and we will help with their interpretation.

Luv - Sheila

Thanks shelia,

appreciate the reply. I have tried just t3 though and still same problem. Don't

think it's a conversion prob now, just the recepter prob. I can't get any

higher currently on my t3 dose, even if lower t4. I do believe t4 does also

work for me. I seem to be a complicated case. Looking into a few things tho.

Thanks again

_,_._,___

[Guest guest]

MODERATED TO REMOVE MOST OF PREVIOUS MESSAGE ALREADY READ. PLEASE CHECK THAT YOU

HAVE DONE THIS BEFORE CLICKING 'SEND'. LUV - SHEILA

_______________________

Hi

this sounds really interesting and I'm going to look into it def with a view to

trying it. Will check with dr p too. Prob just try a very small dose - I wonder

what the amount of t2 would be say in a grain on armour etc?

Am having vits tested and then ordering vit a - prob take couple of weeks all in

all.

Many thanks for all your extensive knowledge and advice. I'm also continuing to

look at this tth1 th2 balance . I've been told can prob assume I'm th2 dominant

but I'd rather have a test so will keep researching and look at some old

threads.

Carly x

>

> Have you ever researched T2 [sic]?

>

> I looked into it a while back and some people were saying they thought it

might play some part in allowing the thyroid receptor to work? Sorry I cannot

remember the articles or exactly what was said. Some fibromyalgia patients have

reported that T2 helped them more than T3.

>

> http://www.powermyself.com/product/SAN_T2_Xtreme_180_Caps_SAN-19 --- T2

>

>

>

[Guest guest]

Check out our Files section I uploaded loads of

information about the lesser known T2 and T1 thyroid hormones, both have an

active role.

Luv - Sheila

Have you ever researched T2 [sic]?

I looked into it a while back and some people were saying they thought it might

play some part in allowing the thyroid receptor to work? Sorry I cannot

remember the articles or exactly what was said. Some fibromyalgia patients have

reported that T2 helped them more than T3.

http://www.powermyself.com/product/SAN_T2_Xtreme_180_Caps_SAN-19

--- T2

have you ordered the vitamin A now?

as always discuss anything like taking T2 with your practitioner....

MARKETPLACE

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..

[Guest guest]

I did! I included a link to the files:

thyroid treatment/files/INFORMATION%20\

\

ABOUT%20T2%20AND%20T1/

:-)

>

> Check out our Files section I uploaded loads of information about the

> lesser known T2 and T1 thyroid hormones, both have an active role.

[Guest guest]

Carly

I'm not trying to muddy the waters further but rather give you another option -

there's aproduct called GTA Forte (and Forte II) which are supposed to contain

porcine T3 (and other things like T2, maybe?). It's not supposed to have T4 in

it. Forte II is stronger than Forte. I think there is a Forte I which is

inbetween.

Some people do ok on it:

http://curezone.com/forums/am.asp?i=1028048

Just thinking in case you can't handle the 'man made' T3 but might do better

with natural T3, but of course we do not know what or how much of anything is in

the Forte

You can get it from :

http://www.revital.co.uk/product_search.cfm?searchString=GTA-Forte

When ordering they may ask for your practitioner name; i gave Dr Peatfield's and

there were no issues with that.

Sheila's right though, vitamins and minerals and reference ranges....essential

fats too if possible, everything ?

Chris

> _______________________

> Hi

> this sounds really interesting and I'm going to look into it def with a view

to trying it. Will check with dr p too. Prob just try a very small dose - I

wonder what the amount of t2 would be say in a grain on armour etc?

[Guest guest]

Hi,

yep I have requested all these tests and will post results in couple wks. Thanks

x

>

> Carly, you should check that you have recently had specific vitamins and

>

mmoderated

[Guest guest]

Hi

>

> I'm not trying to muddy the waters further but rather give you another option

- there's aproduct called GTA Forte (and Forte II) which are supposed to contain

porcine T3 (and other things like T2, maybe?). It's not supposed to have T4 in

it. Forte II is stronger than Forte. I think there is a Forte I which is

inbetween.

" Thankyou - no as much info/suggestions as possible appreciated thankyou. I have

a bit of an idea what to do first but all these other options are useful as my

next options. Thanks! I wonder if the Nutri Thyroid glandular contains other

bits like t2? "

>

>

> Sheila's right though, vitamins and minerals and reference ranges....essential

fats too if possible, everything ?

" Yep - on to it. "

>

> >

> Carly x

[Guest guest]

Hi Jane,

Thanks for the info. Glad you feel its helping you. Yeah im one of these people

that cant always tell if something is helping so thats why thought testing would

be best - but you are right its very expensive... Mmmmm.... I am doing the

immune modulating which isnt specific to either side so will do this for now as

the easier option. Im too am scared of making things worse by doing the wrong

thing. Have you tried the gluthiane cream?

Yes ill def let you knwow if get test done - I wonder is anyone has had it done

at all?

I did have a full panel of immunology bloods done at Kings College earlier in

the year and Im wondering whether they would have tested this - or if I could

work things out from what they've done? Ive requested copied anyway so we shall

see.

Good luck

Carly x

>

> Hi Carly - TH1/TH2 Testing is very expensive - about £300. In the UK there is

True Health Labs - check out their website.

>

> I had over 1000 TPOabs a couple of months ago and researched this as I believe

its important to get deeper into the cause of what`s attacking the thyroid and

why. I found out a lot about the TH1/TH2 being kept in balance, but there`s no

way I could afford to have a proper test. So I worked it out by guessing and

trial and error. To begin with I knew I was not a `reactive histamine` type

person so this led me to think I may be TH1 dominant. I then set about

compiling a list of foods and drinks that I should avoid and a list that I

should add. Yes, I did feel better on Green Tea etc. So I`ve stuck with that

and am still feeling lots better. To confirm it I really should try ingesting

something like Echinacea and see if I react badly as this is a TH1 enhancer, but

I haven`t got the nerve to make myself bad at the moment. I`ve always wondered

why I feel bad after taking Vitamin C and apparently a lot of the immune system

boosters have a detrimental affect because they are actually stimulating the TH1

side of the immune system - its fine if you are TH2 dominant obviously.

>

>> ---

[Guest guest]

Hi we are not talking about the thyroid hormones T2 and

T1 - which you should not be even considering taking. The amounts of T3 and T1

in natural thyroid extract are miniscule, so tiny they are not even measured

but they are powerful nevertheless. We had one guy many years ago who managed

to find some T2 and he started to experiment with it, and he made himself

terribly ill - it was quite a dangerous thing to do.

What we are talking about here is TH-1 and TH-2 are cytokine

messenger cells. Once the gene for an autoimmune disease has been turned on, as

in Hashimoto's disease, it cannot be turned off. The only thing to be done

clinically is to turn down the volume on the immune response by restoring

balance. The trick is to discover which side of your immune system is more

active, the side that deploys natural killer and cytotixic T-cells, or the side

that deploys B-cell antibodies. Are you producing too many natural killer

and cytotoxic T-cells, the ones responsible for killing invaders? If so, you

are TH-1 dominant. (TH stands for T-helper cell). Or are you producing too many

B-cells, the ones in charge of tagging the intruder so it can be readily

identified? If so, you are TH-2 dominant. If you are dominant

in one or the other, our immune system is out of balance and autoimmune disease

is either highly likely or already under way.

In our crime scene, T-helper cells communicate and orchestrates

an immune attack. They are the dispatchers that send messengers to fetch

natural killer, cytotoxic T-cells, and B-cells to the crime scene.

By measuring these messengers, or cytokines, in blood tests, we

can find out whether a patient with an autoimmune disease is TH-1 pr TH-2

dominant. Cytokines are like hormones - they are chemical messengers that make

things happen. Interestingly, TH-1 and TH-2 cytokines affect thyroid

function beyond driving Hashimoto's disease. Elevated TH-1 or TH-2 cytokines

also block thyroid receptor sites preventing thyroid hormone from getting into

the cells, thus causing symptoms of low thyroid activity.

If you want to learn more about Hashimoto's and TH-1 and TH-2

Cytokines, I would buy Dr Datis Kharrazian's Book - Why do I Still Hazve Thyroid

Symptoms when my Lab Tests are Normal?

Luv - Sheila

>

> Have you ever researched T2 [sic]?

>

> I looked into it a while back and some people were saying they thought it

might play some part in allowing the thyroid receptor to work? Sorry I cannot

remember the articles or exactly what was said. Some fibromyalgia patients have

reported that T2 helped them more than T3.

>

> http://www.powermyself.com/product/SAN_T2_Xtreme_180_Caps_SAN-19

--- T2

>

>

>

[Guest guest]

I read here that an estimated 90% of Hashis patients are TH1 dominant :-

http://www.medhelp.org/posts/Thyroid-Disorders/Why-Do-I-Still-Have-Thyroid-Sympt\

oms--When-My-Lab-Tests-are-Normal-by-Datis-Kharrazian/show/1299599

So our killer cells are out in force (obviously more so when stressed), so

apparently that leads to more inflammatory type disorders like rheumatoid

arthritis affecting joints etc.

Jane

>

> >

> What we are talking about here is TH-1 and TH-2 are cytokine messenger

> cells.

[Guest guest]

hi - interestingly my cfs expert believed most cfs patients are th2 dominant-

guess this is where it gets confusing! Hoping my recent immunology tests may

shed some light! X

>

> I read here that an estimated 90% of Hashis patients are TH1 dominant :-

>

>

http://www.medhelp.org/posts/Thyroid-Disorders/Why-Do-I-Still-Have-Thyroid-Sympt\

oms--When-My-Lab-Tests-are-Normal-by-Datis-Kharrazian/show/1299599

>

> So our killer cells are out in force (obviously more so when stressed), so

apparently that leads to more inflammatory type disorders like rheumatoid

arthritis affecting joints etc.

> Jane

>

> ---

>

>

[Guest guest]

Hi Carly - yes it gets confusing when there is no consensus of opinion from the

scientific bods.

Jane

> >

> > I read here that an estimated 90% of Hashis patients are TH1 dominant :-

> >

> >

http://www.medhelp.org/posts/Thyroid-Disorders/Why-Do-I-Still-Have-Thyroid-Sympt\

oms--When-My-Lab-Tests-are-Normal-by-Datis-Kharrazian/show/1299599

> >

> > So our killer cells are out in force (obviously more so when stressed), so

apparently that leads to more inflammatory type disorders like rheumatoid

arthritis affecting joints etc.

> > Jane

> >

> > ---

> >

> >

>