Re: on behalf of my Mum...

[Guest guest]

Hi Nicola:

NAX is missing two very important B vitamins which need to be supplemented all

together. It is missing both Biotin and Folate. You cannot take some B vitamins

without the other B vitamins because they will get out of balance in your

system. I would also put her on a senior Spirulina supplement as soon as

possible.

Cheers,

JOT

So, over the past few days she's been weaning herself off the thyroxine and will

start her NAX on Friday. She's got a doc appt on Thursday to ask for

Naturethroid from the same GP who first gave me Armour.

[Guest guest]

Hi Jot

Many thanks for the info. I'll make sure Mum gets all of those.

Just wondering if you happen to know what dose of Naturethroid Mum should start

on after her week of just Adrenomax (she's never been on NDT before but was on

125mcg Levo for about 40 years until this week).

Also, I really need to know at what rate Mum should then increase the

Naturethroid.

Many thanks as always - really appreciate the help.

Nicola

>

>

> Hi Nicola:

>

> NAX is missing two very important B vitamins which need to be supplemented all

together. It is missing both Biotin and Folate... I would also put her on a

senior Spirulina supplement as soon as possible.

>

[Guest guest]

Go to the files section here and look for *how to use Natural Thyroid meds,*

Print this out so you can refer to it often.

thyroid treatment/files/ALL%20NATURAL%\

20DESICCATED%20THYROID%20INFO./

I assume your mother's adrenals are probably not up to snuff so starting slow

with NT is the best way to go. If it were me, I'd just start with 1/4 grain (15

mgs) and go from there. Broda generally started everyone with one grain

back in his day, but now that we have so many problems with deficiencies and

toxins, we don't do that anymore. It's too much on the system. I would suggest

that she stop all addictive substances as well, coffee, soda, sugar, cigs, etc.

All these substances play into the workings of your body and must be deleted for

the best results. I'd like to see her take celtic sea salt every day in a glass

of water first thing in the morning as well. This will enhance her system by

providing the essential trace minerals which is may be missing as well.

Cheers,

JOT

> Many thanks for the info. I'll make sure Mum gets all of those.

> Just wondering if you happen to know what dose of Naturethroid Mum should

start on after her week of just Adrenomax (she's never been on NDT before but

was on 125mcg Levo for about 40 years until this week).

[Guest guest]

Hello Nicola

If this was me, I would go for the Erfa Thyroid rather than

Nature Throid. This is because the Erfa 'Thyroid' can be taken sublingually and

so is absorbed directly through the tiny capillaries under the tongue into the

blood stream. I believe that the manufacturers of Nature Throid also changed

the fillers in their product as did Forest Pharmaceuticals with Armour Thyroid,

removing some of the dextrose and adding more cellulose and a lot of people had

difficulty in getting the dose right. You need to chew these up and then

swallow them with plenty of water which can be a nuisance.

Your Mum should ask for the 60mgs tablets (1 grain in the old

measure). She should then follow the instructions in the attached document (let

me know if you cannot see this) - in which case, go to our FILES SECTION and on

the page that opens, click on 'Natural Thyroid Extract' - and then scroll down

and click on the document 'How to Treat with Natural Thyroid Extract' and

follow the instructions from there.

Your Mum should ask the GP to test specific vitamins and

minerals because if any of these are low in the reference range, no amount of

thyroid hormone can be properly utilised in the cells, where it needs to do its

work. These are iron, transferrin saturation %, ferritin, vitamin B12, vitamin

D3, magnesium, folate, copper and zinc. There are many studies and research

that have been done to show of the connection between these low levels and low

thyroid. If any of these vits/mins. are found to be low in the reference range,

she will need to supplement with whatever is low. When you get the results, post

them on the forum together with the reference range for each of the tests done

and we can then take it from there.

Follow the instructions to the letter, and do realise that she

must not take any thyroid hormone replacement on the morning she is going to

have her thyroid levels tested because doing so, would make the results invalid.

This is because the T3 in natural thyroid extract is the ACTIVE thyroid hormone

and because it has such a very short half-life, it peaks in the blood a couple

or so hours after taking it. When doctors see this, they panic, tell their

patients they are taking too high a dose, and that they must reduce or stop it

immediately. This is wrong - if the same blood test was done several hours

later in the day, the doctor would then see the level of T3 had dropped,

possibly by half.

This is why we always recommend splitting the dose in half and

taking half in the morning when she gets up, and the other half around

2.00p.m./3.00p.m. to 'keep the engine topped up'.

Please don't panic, you are not likely to " damage "

your lovely Mum - you will be helping her enormously. It may reassure you to

know that we have estimated there are around 250,000 citizens in the UK alone

who are being left without the correct thyroid hormone replacement their body

needs, simply because doctors are taught that thyroxine-only restores optimal

health and it always converts to the active thyroid hormone T3 - unfortunately,

it doesn't. These patients need T3, either synthetic in combination with T4, T3

alone or natural thyroid extract.

Good luck with your Mum and well done for looking after her so

well.

Luv - Sheila

We need to know what dosage of Naturethroid Mum should start on after the week

of just NAX.

You see, it's one thing self-medicating, but it's quite another trying to treat

your own Mum who you love very much and don't want to damage in any way!!!!!

I'm feeling the pressure and want to make sure I don't mess up!

Also, how slowly should Mum increase the Naturethroid since she's never been on

NDT before? (Not sure if it's relevant but she's been on 125mcg Levo for most

of the last 4 decades).

As always, would appreciate your input...

Best wishes,

Nicola

1 of 1 File(s)

A22.HOW TO TREAT WITH NATURAL THYROID EXTRACT.doc

[Guest guest]

I was on T4 / t3 for years and then I decided to change to dessicated

thyroid.... I started on half a grain with the intention of upping the dosage

as per the files.... But I had a terrible time with severe hypo symptoms.....

This was on Erfa a couple of years ago. I stopped taking the erfa and went

back to T3/T4.

The instructions, I think, assume you've not taken anything before. I started

Nature throid last December and this time, instead of starting very low, I just

started on a grain and a half and then worked up......

>

> Go to the files section here and look for *how to use Natural Thyroid meds,*

> Print this out so you can refer to it often.

>

>

thyroid treatment/files/ALL%20NATURAL%\

20DESICCATED%20THYROID%20INFO./

>

> I assume your mother's adrenals are probably not up to snuff so starting slow

with NT is the best way to go. If it were me, I'd just start with 1/4 grain (15

mgs) and go from there. Broda generally started everyone with one grain

back in his day, but now that we have so many problems with deficiencies and

toxins, we don't do that anymore. It's too much on the system. I would suggest

that she stop all addictive substances as well, coffee, soda, sugar, cigs, etc.

All these substances play into the workings of your body and must be deleted for

the best results. I'd like to see her take celtic sea salt every day in a glass

of water first thing in the morning as well. This will enhance her system by

providing the essential trace minerals which is may be missing as well.

>

> Cheers,

> JOT

>

> > Many thanks for the info. I'll make sure Mum gets all of those.

> > Just wondering if you happen to know what dose of Naturethroid Mum should

start on after her week of just Adrenomax (she's never been on NDT before but

was on 125mcg Levo for about 40 years until this week).

>

[Guest guest]

Hello Sheila

Thank you so much once again for your help and support. Mum's GP appt is

tomorrow morning and so she's going to ask for Erfa Thyroid instead. She has

also completely stopped all sugar and gluten in the past couple of days and

hasn't smoked in 40 years, so is really committed to improving her health. I'll

keep you updated on how it all goes with Mum.

As regards the Naturethroid, I'm completely gutted because I actually quit

Armour because of the reformulation, and now I'm told that the same has been

done to NT also!!! But I'm going to have to stick with the NT because I made

such a fuss with the GP to get switched from Armour and I daren't ask for

another switch. I'm already seriously in the GP's bad books!

Thanks again, and Happy Birthday,

Nicola

>

> Hello Nicola

>

> If this was me, I would go for the Erfa Thyroid rather than Nature Throid.

I believe that the manufacturers of Nature Throid also changed

> the fillers in their product as did Forest Pharmaceuticals with Armour

> Thyroid... Good luck with your Mum and well done for looking after her so

well.

>

> Luv - Sheila

>

[Guest guest]

Hi ,

Many thanks for the info again. I'm just hoping Mum will be ok on all this new

treatment since, like so many other poor people, she's been on the same Levo for

decades. I reckon she'll probably start on 1 grain/day, split into 2 doses and

see how she feels with that, and just increase really slowly after that.

best wishes

Nicola

>

> I was on T4 / t3 for years and then I decided to change to dessicated

thyroid.... I started on half a grain with the intention of upping the dosage

as per the files.... But I had a terrible time with severe hypo symptoms.....

this time, instead of starting very low, I just started on a grain and a half

and then worked up......

>

>

[Guest guest]

Just a quick (positive!)update and some questions:

Mum was refused NDT by her GP but I then wrote to the GP, asking that Mum be

allowed to start adding T3 to her T4. I enclosed some TPA documentation, and

the GP agreed to let Mum add in the T3. To cut a long story short, Mum started

5mcg T3 just over a week ago, which she takes around 7am. Yesterday, she added

a second dose of 5mcg at 2pm. The amazing news is that she already feels so

much better. She has much more energy, is much less depressed, and has much

less shoulder and neck pain. Thank you to Sheila and those of you who gave me

much-needed advice which has helped Mum so much.

Now for those questions:

1 When Mum needs to increase her dose from 10 to 15mcg in a few days time,

should she take 10 in the morning and 5 at 2pm, or should she add a third time

later in the day?

2 Every single morning when Mum takes her 2 Adrenomax, she immediately feels

her whole body starting to burn. I happened to be there a couple of days ago

when she took them, and she literally went bright red, from top to toe. She

looks like she's just been sunbathing for about 8 hours! After about 30 minutes

the burning feeling and the redness subside and she feels fine. Is this normal?

3 When Mum got her iron tested, the serum iron and saturation percentage were

well below normal, but the ferritin was 124. I guess I was expecting it to be

low too. Is this 124 normal? (She has since started on iron supplements)

Thanks for any guidance you can give...

Best wishes,

Nicola

>

> Hello Nicola

>

> Your Mum should ask the GP to test specific vitamins and minerals because.....

These patients need T3, either synthetic in

> combination with T4, T3 alone or natural thyroid extract.

>

> Good luck with your Mum and well done for looking after her so well.

>

> Luv - Sheila

>

[Guest guest]

NIcola,

I bet the flushing is because of Niacin, which is one of he B vitamins. I took

some and thought I was going to die when I went beetroot red and very hot. I

looked it up later and laughed!

I would take the T3 in 3 doses, if she does 7 am then she could do 7 pm and

something in between..... say 1 pm... although some people take it all at

once.... I take 25 mcg last thing at night and do well on it.

x

>

> Just a quick (positive!)update and some questions:

>

> Mum was refused NDT by her GP but I then wrote to the GP, asking that Mum be

allowed to start adding T3 to her T4. I enclosed some TPA documentation, and

the GP agreed to let Mum add in the T3. To cut a long story short,

[Guest guest]

I always get a lump in my throat when I hear that somebody is

regaining their health by adding some T3 - this is really wonderful news

Nicola. To answer your questions, T3 has a very short half life and the effect

starts to wear off after 6 to 8 hours and that is why we split the dose

throughout the day. However, I personally think it best at this stage to split

the dose equally to keep the engine topped up.

Do you know if the Adrenal Max has vitamin B3 as one of the

ingredients, if so it could be this. B3 is Niacin, and Niacin can cause

flushing. This is nothing to worry about, this is caused because all her

capillaries are opening up and this is good to get the blood flowing well. If

she takes an Aspirin, this should stop the 'flushing' and she should take the

Adrenal Max with food too. Can you let us know how much B3 there is in the

tablet. Tell your Mum not to worry, - it's a 'good' symptom to have, even

though at the moment, it is making her feel uncomfortable. Knowing what is

happening is half the battle.

Her ferritin of 124 is absolutely fine, and normal. Ferritin is

stored iron. However, I am pleased she has started iron supplements, but please

tell her to take any iron/calcium at least four hours apart from her thyroid

hormone replacement.

luv - Sheila

Now for those questions:

1 When Mum needs to increase her dose from 10 to 15mcg in a few days time,

should she take 10 in the morning and 5 at 2pm, or should she add a third time

later in the day?

2 Every single morning when Mum takes her 2 Adrenomax, she immediately feels

her whole body starting to burn. I happened to be there a couple of days ago

when she took them, and she literally went bright red, from top to toe. She

looks like she's just been sunbathing for about 8 hours! After about 30 minutes

the burning feeling and the redness subside and she feels fine. Is this normal?

3 When Mum got her iron tested, the serum iron and saturation percentage were

well below normal, but the ferritin was 124. I guess I was expecting it to be

low too. Is this 124 normal? (She has since started on iron supplements)

[Guest guest]

Sheila,

I cannot find any link to the counter example survey in the files section and do not have the link. Should Nicola's mother be given the opportunity to sign it.

Lilian

I always get a lump in my throat when I hear that somebody is regaining their health by adding some T3 - this is really wonderful news Nicola.

[Guest guest]

Nicola,

Please read this survey and if possible get your mother to sign it. I am not

sure whether you would be allowed to sign it on her behalf, but I do not see why

not. It is for people who have improved on T3.

The link to it is http://www.surveymonkey.com/s/BZYHTK3

Actually if anyone else is reading this who has not yet signed this survey, and

who has improved health after taking T3, it would be helpful to our cause if you

also please sign it.

Lilian

[Guest guest]

Nicola - I can second what has said about the NAMx. I had that flushing

when I took it on an empty stomach. Make sure your Mum takes it with food.

Jane

>

>

> NIcola,

>

> I bet the flushing is because of Niacin, >

> x

>

>

>

[Guest guest]

Hi Sheila

Thank you so much again for all your help and advice about the T3 and the

Adrenomax. The difference in Mum's whole being within a few short days makes it

all worthwhile.

No doubt I'll be back soon though with more questions!!

Take care,

Nicola

>

> I always get a lump in my throat when I hear that somebody is regaining

> their health by adding some T3 - this is really wonderful news Nicola. To

> answer your questions, T3 has a very short half life and the effect starts

> to wear off after 6 to 8 hours and that is why we split the dose throughout

> the day.

[Guest guest]

Thanks a million Jane and !

Actually, Mum found the whole hot flushing thing hilarious since she's been used

to being absolutely freezing 24/7 for the last 45 years!! She literally looked

like she'd spent about 12 hours under a sunbed!

I was the one who was worried by it, in case it indicated she was allergic to

the Adrenomax or something.

But now I'm totally reassured.

Thanks again,

Nicola

> >

> >

> > NIcola,

> >

> > I bet the flushing is because of Niacin, >

> > x

> >

> >

> >

>

[Guest guest]

Dear friends, I come to you again seeking help for my Mum before her GP

appointment next week.

When Mum was first prescribed T3 nearly a month ago, her GP insisted that Mum

would have to have a TSH blood test after 4 weeks and that the results of this

test would determine whether or not she would allow Mum to stay on the T3.

Now, as I have posted previously, Mum already feels brilliant on the T3 and is

really dreading this GP appointment next week in case the GP takes her off it.

Mum is very low in confidence and self-esteem and would never dream of 'talking

back' to anyone, never mind a doctor.

As a result, I am in the process of writing a letter for her to take to the

appointment and I need to check some things so that I get my facts right.

Would I be right in saying that someone who is on a combination of T3 and T4

should not be assessed according to the results of a TSH blood test?

Would I be right in saying that no blood test will be of value, and that Mum

should be allowed to dose according to her symptoms alone?

If so, obviously, the idea of dosing according to the elimination of symptoms

will be a whole new concept for this GP, so is there any supporting evidence I

can supply to back this up?

I was thinking of including a photocopy of 's article from the

recent TPA newsletter which gives invaluable info about using T3... The only

thing is that the title " Why I believe T3 should be the very last treatment that

thyroid patients consider " might scare the life out of Mum's GP before she's

even read it!!!

I would really value your advice on this one so that I can make a good job of

this letter and ensure that Mum can continue her improvement on T3.

Many thanks, as always,

Nicola

>

> I always get a lump in my throat when I hear that somebody is regaining

> their health by adding some T3 - this is really wonderful news Nicola.

> luv - Sheila

[Guest guest]

As a result, I am in the process of writing a

letter for her to take to the appointment and I need to check some things so

that I get my facts right.

Would I be right in saying that someone who is on a combination of T3 and T4

should not be assessed according to the results of a TSH blood test'

NOBODY should be assessed for thyroid function by a TSH test

alone. TSH can take weeks/months to change after a thyroid medication has been

changed, and for anybody taking T3, whether synthetic or natural, TSH is ALWAYS

suppressed.

Would I be right in saying that no blood test

will be of value, and that Mum should be allowed to dose according to her symptoms

alone?

Yes, T3 has a very short half life. It peaks in the blood

between 2 to 4 hours after taking it so any blood test done to check her levels

of free T4 or free T3 would be flawed if she took her medication the morning of

the blood draw. In your Mum's case, I would highly recommend that she takes her

T3 as usual the day before the blood test, but that she doesn't take any on the

morning of the test, but to take her T3 with her so that she can take it

immediately after the blood has been drawn.

If so, obviously, the idea of dosing according

to the elimination of symptoms will be a whole new concept for this GP, so is

there any supporting evidence I can supply to back this up?

I think the whole idea of dosing with T3 will be anathema to

your Mum's GP as she is very likely to have been brainwashed by the usual diagnosing

and treatment of hypothyroidism clap-trap that has come from the RCP, BTA. Unfortunately,

doctors are being taught that they should only use thyroid function tests to

titrate a patients thyroid hormone replacement therapy, which doesn't work with

T3. It needs to be done according to symptoms and signs.

However, here are just some of the references to

research/studies you might wish to pass on with your letter.

Thyroxine-triiodothyronine

associations

1. Rees- RW, Larsen

PR. Triiodothyronine and thyroxine content of desiccated thyroid tablets.

Metabolism. 1977 Nov;26(11):1213-8

2. Mangieri CN, Lund MH.

Potency of United States Pharmacopeia desiccated thyroid tablets as determined

by the antigoitrogenic assay in rats. J Clin Endocrinol Metab. 1970

Jan;30(1):102-4

3. Gaby AR.

Sub-laboratory hypothyroidism and the empirical use of Armour thyroid. Altern

Med Rev. 2004 Jun;9(2):157-79

4. Hertoghe T, Lo Cascio

A., Hertoghe J. Considerable improvement of hypothyroid symptoms with two

combined T3-T4 medication in patients still symptomatic with thyroxine

treatment alone. Anti-Aging Medicine (Ed. German Society of Anti-Aging

Medicine-Verlag 2003) 2004;  32-43

5. Hertoghe T. Many

conditions related to age reduce the conversion of thyroxine to

triiodothyronine - a rationale for prescribing preferentially a combined T3

+ T4  preparation in hypothyroid adults.  Anti-Aging Medical

Therapeutics 2000; IV: 138-53

Arguments pro

treatment with T4 and T3 combinations

T3-T4 (and T3)

treatments work better than T4

1. Saravanan P,

DJ, Greenwood R, s TJ, Dayan CM. Partial substitution of thyroxine (T4)

with tri-iodothyronine in patients on T4 replacement therapy: results of a

large community-based randomized controlled trial. Clin Endocrinol Metab. 2005

Feb;90(2):805-12

2. Kloppenburg M, Dijkmans BA, Rasker JJ. Effect of therapy for thyroid dysfunction on musculoskeletal symptoms. Clin Rheumatol. 1993 Sep;12(3):341-5

3.

Hertoghe

T, Lo Cascio A., Hertoghe J. Considerable improvement of hypothyroid symptoms

with two combined T3-T4 medication in patients still symptomatic with thyroxine

treatment alone. Anti-Aging Medicine, Ed. German Society of Anti-Aging

Medicine-Verlag 2003- 2004; 32-43

4.

Pareira VG, Haron ES, Lima-Neto N,

Medeiros-Neto GA. Management

of myxedema coma: report on three successfully treated cases with nasogastric

or intravenous administration of triiodothyronine. J Endocrinol Invest.

1982;5:331-4

5.

Chernow

B, Burman KD, DL, McGuire RA, O' JT, Wartofsky L, s LP. T3

may be a better agent than T4 in the critically ill hypothyroid patient:

evaluation of transport across the blood-brain barrier in a primate model. Crit

Care Med. 1983 Feb;11(2):99-104

6.

Arlot

S, Debussche X, Lalau JD, Mesmacque A, Tolani M, Quichaud J, Fournier A.

Myxoedema coma: response of thyroid hormones with oral and intravenous

high-dose L-thyroxine treatment. Intensive Care Med. 1991;17(1):16-8

T3-T4 treatment:

adding T3 to T4 results in greater improvement of clinical symptoms and signs

in hypothyroid patients

7.

Benevicius R, Kazanavicius G, Zalinkovicius

R, Prange AJ. Effects of thyroxine as compared with thyroxine plus

triiodothyronine in patients with hypothyroidism.  N Engl J Med.1999; 340:

424-9.

When T3 and T4 are

both supplemented to the food simultaneously with goitrogens, a much better

prevention of goiter is obtained than when solely T4 is added, even if T4 is

given at doses 7 times higher those of T3-T4 treatments

8.

Devlin

WF, Watanabe H. Thyroxin-triiodothyronine concentrations in thryoid powders. J Pharm

Sci. 1966 Apr;55(4):390-3

In humans, T4-T3

treatments reduce serum cholesterol and increase the speed of the Achilles

tendon reflexes better than T4 treatments alone

9.

Alley RA, Danowski TS, Robbins T JL, Weir TF,

Sabeh G, and Moses CL. Indices during administration of T4 and T3 to euthyroid

adults. Metabolism. 1968;17(2):97-104

A study in rats

rendered hypothyroid shows that cellular euthyroidism is only obtained in the

target organs of hypothyroid rats if T3 is added to the classic T4 medication

10. Escobar-Morreale HF,

del Rey FE, Obregon MJ, de Escobar GM. Only the combined treatment with

thyroxine and triiodothyronine ensures euthyroidism in all tissues of the

thyroidectomized rat. Endocrinology. 1996 Jun;137(6):2490-502

11. Escobar-Morreale

HF, Obregon MJ, Escobar del Rey F, Morreale de Escobar G. Replacement therapy

for hypothyroidism with thyroxine alone does not ensure euthyroidism in all

tissues, as studied in thyroidectomized rats. J Clin Invest. 1995

Dec;96(6):2828-38

Medications with T4

alone do not succeed in achieving complete cellular euthyroidism in the target

organs, probably

because T3 is really the active hormone

12. Asper SP

Jr, Selenkow HA, and Plamondon CA. A comparaison of the metabolic activities of

3,5,3’-triiodothyronine and l-thyroxine in myxedema. Bull Hopkins

Hosp. 1953; 93: 164

13. Blackburn

CM, McConahey WM, Keating FR Jr, Albert A. Calorigenic effects of single

intravenous doses of l-triiodothyronine and l-thyroxine in myxedematous

persons. J

Clin Invest. 1954 Jun;33(6):819-24

T3 is much more

potent than T4

14. Gross J,

Pitt-Rivers R. Physiological

activity of 3:5:3'-L-triiodothyronine. Lancet. 1952 Mar 22;1(12):593-4

15. Gross J,

Pitt-Rivers R.  3:5:3'-triiodothyronine.

2. Physiological activity. Biochem J. 1953 Mar;53(4):652-7

Conditions that

reduce the conversion of T4 to T3 such as aging, obesity, disease,

stress, exercise, malnutrition, etc., reducing thereby the efficacy of a T4

alone treatment

16. Burroughs

V, Shenkman L. Thyroid function in the elderly. Am J Med Sci. 1982, 283 (1):

8-17

17. JN,

Eastman CJ, Corcoran JM, and Lazarus L. Inhibition of conversion of thyroxine

to triiodothyronine in patients with severe chronic illness. Clin Endocrinol.

1976; 5: 587-94

18. Tulp OL

and McKee TD Sr.  Triiodothyronine neogenesis in lean and obese LA/N-cp rats.

Biochem Biophys Res Communications. 1986; 140 (1): 134-42

19. Katzeff

HI, Selgrad C. Impaired peripheral thyroid hormone metabolism in genetic

obesity. Endocrinology. 1993; 132 (3): 989-95

20. Croxson MS

and Ibbertson HK. Low serum triiodothyronine (T3) and hypothyroidism in

anorexia nervosa.  J Clin Endocrinol Metab. 1977; 44: 167-73

21. Harns ARC,

Fang SH, Vagenakis AG, and Braverman LE. Effect of starvation, nutriment

replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the

rat. Metabolism. 1978;27(11):1680-90

22. Opstad PK,

Falch D, Öktedalen O, Fonnum F, and Wergeland R.  The thyroid function in young

men during prolonged physical exercise and the effect of energy and sleep

deprivation. Clin Endocrinol. 1984; 20: 657-69

23. Walfish

PG. Triiodothyronine and thyroxine interrelationships in health and disease.

Can Med Ass. J 1976, 115: 338-42

Toxic substances such as

phenols, cadmium, mercury, etc, and medications such as propranolol, amiodarone

and several others may interfere by stimulating or inhibiting the T4 to T3

conversion

24. Feyes D,

Hennemann G and Visser TJ. Inhibition of iodothyronine deiodinase by

phenolphtalein dyes. Fed Eur Biomed Sci. 1982; 137(1):40-4

25. Bahn AK,

Mills JL, Snyder PJ, Gann PH, Houten L, Bialik O, Hollmann L, and Utiger RD.

Hypothyroidism in workers exposed to polybrominated biphenyls. N Engl J Med.

1980; 302: 31-3

26. Ikeda T, Ito Y,

Murakami I, Mokuda O, Tominaga M and Mashiba H. Conversion of T4 to

T3 in perfused liver of rats with carbontetrachloride-induced liver injury.

Acta Endocrinol. 1986;112: 89-92

27. Paier B,

Hagmüller K, Nolli Mi, Pondal M, Stiegler C and Zaninovich AA. Changes

induced by cadmium administration on thyroxine deiodination and sulfhydryl

groups in rat liver. J Endocrinol. 1993; 138: 219-24

28. Barregärd

L, Lindstedt G, Schütz A, Sällsten G. Endocrine function in mercury exposed

chloralkali workers. Occup Envir Med. 1994; 51: 536-40

Deficiencies in

hormones (T3

itself, TSH, growth hormone, insulin, melatonin, etc)

and trace elements (selenium, iron, zinc, cupper, etc) partially block this

essential step for thyroid function

29. Burger AG, Lambert M,

Cullen M. Interférence de substances médicamenteuses dans la conversion de T4

en T3 et rT3 chez l’homme. Ann Endocrinol (Paris). 1981,42:461-9

30. Grussendorf M, Hüfner

M. Induction of the thyroxine to triiodothyronine converting enzyme in rat

liver by thyroid hormones and analogs. Clin Chim Acta. 1977;80:61-6

31. kson VJ,

Cavalieri RR, Rosenberg LL. Thyroxine-5’-diodinase of rat thyroid, but

not that of liver, is dependent on thyrotropin.  Endocrinology.

1982;111:434-40

32. Rezvani I,

Di AM, Dowshen SA, Bourdony CJ. Action of human growth hormone on

extrathyroidal conversion of thyroxine to triiodothyronine in children with

hypopituitarism. Pediatr Res. 1981;15:6-9

33. Schröder-Van der elst

JP, Van der heide D. Effects of streptozocin-induced diabetes and

food restriction on quantities and source of T4 and T3 in rat tissues.

Diabetes. 1992;41:147-52

34. Gavin LA,

Mahon FA, Moeller M. The mechanism of impaired T3 production from T4 in

diabetes. Diabetes. 1981;30:694-9

35. Hoover PA,

Vaughan MK, Little JC, Reiter RJ. N-methyl-D-aspartate does not prevent effects

of melatonin on the reproductive and thyroid axes of male Syrian hamsters. J

Endocrinology. 1992;133:51-8

36. Chanoine

J-P, Safran M, Farwell AP, Tranter P, Ekenbarger DM, Dubord S, s, Arthur

JR, Beckett GJ, Braverman LE, Leonard JL. Selenium deficiency and type II

5’-deiodinase regulation in the euthyroid and hypothyroid rat: evidence

of a direct effect of thyroxine. Endocrinology. 1992;130:479-84

37. Arthur JR,

Nicol F, Beckett GJ. Selenium deficiency, thyroid hormone metabolism, and

thyroid hormone deiodinases. Am J Clin Nutr Suppl. 1993; 57:236S-9S

38. Beard J,

Tobin B, and Green W. Evidence for thyroid hormone deficiency in iron-deficient

anemic rats. J Nutr. 1989;772-8

39. Fujimoto

S, Indo Y, Higashi A, Matsuda I, Kashiwabara N, and Nakashima I.  Conversion

of thyroxine into triiodothyronine in zinc deficient rat liver.  J Pediatr

Gastroenterol Nutr. 1986;5:799-805

40. Olin KI,

Walter RM, and Keen CL.  Copper deficiency affects selenoglutathione peroxidase

and selenodeiodinase activities and antioxidant defense in weanling rats.  Am J Clin

Nutr 1994;59:654-8

41. Westgren U,

Ahren B, Burger A, Ingemansson S, Melander A.  Effects of dexamethasone,

desoxycorticosterone, and ACTH on serum concentrations ot thyroxine,

3,5,3’-triiodothyronine and 3,3’,5’-triiodothyronine.  Acta Med

Scand. 1977;202 (1-2): 89-92

On the other hand,

excesses in hormones (glucocorticoids, ACTH, estrogens,…)

and trace elements (iodine, lithium, …) may slow down this

conversion.

42. Heyma P,

Larkins RG. Glucocorticoids decrease the conversion of thyroxine into

3,5,3’-triiodothyronine by isolated rat renal tubules. Clin Science.

1982; 62: 215-20

43. Scammell JG,

Shiverick KT, Fregly MJ. Effect of chronic treatment with estrogen and

thyroxine, alone and combined, on the rate of deiodination of l-thyroxine to

3,5,3’-triiodothyronine in vitro. Pharmacology. 1986;33: 52-7

44. Aizawa T,

Yamada T. Effects of thyroid hormones, antithyroid drugs and iodide on in vitro

conversion of thyroxine to triiodothyronine. Clin Exp Pharmacol

Physiol. 1981; 8: 215-25

45. Voss C,

Schrober HC, Hartmann N. Einfluss von Lithium auf die in vitro-Deioderung von

l-Thyroxin in der Ratten leber. Acta Biol Med Germ. 1977; 36:1061-5

The absorption of

oral T4 can be variable (50 to 73%40,41), contrasting with that of

T3 that is more constant and efficient (95%)

46. Hays MT.

Absorption of oral thyroxine in man. J Clin Endocrinol Metab. 1968; 28

(6):749-56

47. Surks MI,

Schodlow AR, Stock Jm, Oppenheimer JH. Determination of iodothyronine

absorption and conversion of L-thyroxine using turnover rate techniques. J Clin

Invest. 1973; 52:809-11

48. Hays MT.

Absorption of triidothyronine in man. J Clin Endocrinol Metab. 1970;

30(5):675-6

Defects in the commercial

T4 preparation43,44

49. Hubbard

WK. FDA notice regarding levothyroxine sodium. Federal register. 1997; 62(157):

1-10

50. Peran S,

Garriga MJ, Morreale de Escobar G, Asuncion M, Peran M. Increase in plasma

thyrotropin levels in hypothyroid patients during treatment due to a defect in

the commercial preparation . J Clin Endocrinol Metab. 1997;82(10):3192-5

I was thinking of including a photocopy of 's article from the

recent TPA newsletter which gives invaluable info about using T3... The only

thing is that the title " Why I believe T3 should be the very last

treatment that thyroid patients consider " might scare the life out of

Mum's GP before she's even read it!!!

You are not the first person to comment on the 'odd' - and quite

off-putting title, as this puts a lot of people off and I personally think it

should have been changed. Even Dr Peatfield asked why on earth it had been

given such a title. It is something I meant to talk to about because he

has lived with this for so long, I doubt he is realising that it is putting

over the wrong message completely. We understand what he means and why he says

this, but it should not be used as a title to a paper he wants people to read.

Luv - Sheila

I would really value your advice on this one so that I can make a good job of

this letter and ensure that Mum can continue her improvement on T3.

Many thanks, as always,

Nicola

>

> I always get a lump in my throat when I hear that somebody is regaining

> their health by adding some T3 - this is really wonderful news Nicola.

> luv - Sheila

[Guest guest]

Sheila

All I can say is thanks so much and... wow!!!

If your exhaustive list of references doesn't do the trick, nothing will!

By the way, if ever you need anyone to put up posters or distribute flyers in my

local area (County Down, N Ireland), I'd be more than willing to help out. I

just feel so thankful to have found TPA, and feel so sorry for all the thousands

of people out there who are suffering needlessly at the hands of the NHS and are

none the wiser. Anything I can do to spread the news, I'll do.

Thanks again Sheila,

Take care,

Nicola

>>

> NOBODY should be assessed for thyroid function by a TSH test alone. TSH can

> take weeks/months to change after a thyroid medication has been changed, and

> for anybody taking T3, whether synthetic or natural, TSH is ALWAYS

> suppressed.

[Ed]

[Guest guest]

Hi Nicola, you are very welcome. Have you considered running a

local Thyroid Patient Advocacy group where you live, for those who need others

to talk to. All you need to do is find a venue - a local pub or perhaps a café where

they have a separate room where you could hold the meeting, and put up some

adverts in y our local library, doctors surgeries, slimming clubs, WI's, local

post offices, supermarket notice boards, or any such places where people stick

notices.  I have attached a poster you could start off with.

You could add something to it to say that if people would like

to find out more about it and are seeking help and support, to attend your

meeting along with others who find themselves in the same position giving

details of date, and venue. Then, simply take it from there.

If we have other members who would like to start a local TPA

support group where you live, whether in the UK, USA, outer space, then please

let me know.

Luv - Sheila

Sheila

All I can say is thanks so much and... wow!!!

If your exhaustive list of references doesn't do the trick, nothing will!

By the way, if ever you need anyone to put up posters or distribute flyers in

my local area (County Down, N Ireland), I'd be more than willing to help out. I

just feel so thankful to have found TPA, and feel so sorry for all the

thousands of people out there who are suffering needlessly at the hands of the

NHS and are none the wiser. Anything I can do to spread the news, I'll do.

Thanks again Sheila,

Take care,

Nicola

>>

> NOBODY should be assessed for thyroid function by a TSH test alone. TSH

can

> take weeks/months to change after a thyroid medication has been changed,

and

> for anybody taking T3, whether synthetic or natural, TSH is ALWAYS

> suppressed.

[Ed]

1 of 1 File(s)

TPA POSTER.doc

[Guest guest]

Hi Lilian

I haven't put the link to the Register of Counterexamples to

T4-only therapy in the Files section, but it is on our web site and I send out

the link to all our members about every 3 months. The link is http://www.tpa-uk.org.uk/two_world_thyroid_registers.php

Luv - Sheila

Sheila,

I cannot find any link to the counter example survey in the files

section and do not have the link. Should Nicola's

mother be given the opportunity to sign it.

Lilian

.._,___