Guest guest Posted September 20, 2011 Report Share Posted September 20, 2011 Who on earth is looking after your sister and can you let us have the results of recent thyroid function tests together with the reference range for each test done. Has she been tested to see whether she has thyroid antibodies (TPO, TgAb) especially as you too have hypothyroidism. If not, she must get tested to see if she has Hashimoto's disease. If she has antibodies, she should know that antibodies thrive on gluten so if she is eating a diet high in gluten, she might wish to consider going on a gluten free diet. Is there the slightest chance she could see Dr Peatfield or Dr Skinner (our medical advisers?) There are MANY reasons and many medical conditions associated with thyroid disease that stop thyroid hormone from getting into the cells, where it does its work. I mention these over and over and over again - ad nauseum - people must be bored with the same old, same old but as each new member joins us, they need to know. The main condition responsible for stopping thyroid hormone from working, is, quite simply, a patients thyroxine dose is too low because the doctor or consultant refuses to increase it, because the serum thyroid function test results appear OK. Sometimes, the thyroxine dose is too high, yet patients still don't feel well. They continue to suffer. Some reasons for this: They may be suffering with low adrenal reserve. The production of T4, its conversion to T3, and the receptor uptake requires a normal amount of adrenal hormones, notably, of course, cortisone. (Excess cortisone can shut production down, however.) This is what happens if the adrenals are not responding properly, and provision of cortisone usually switches it on again. But sometimes it doesn’t. If the illness has been going on for a long time, the enzyme seems to fail. This conversion failure (inexplicably denied by many endocrinologists) means the thyroxine builds up, unconverted. So it doesn’t work, and T4 toxicosis results. This makes the patient feel quite unwell, toxic, often with palpitations and chest pain. If provision of adrenal support doesn’t remedy the situation, the final solution is the use of the active thyroid hormone, already converted, T3 - either synthetic or natural. Then, we have systemic candidiasis. This is where candida albicans, a yeast, which causes skin infections almost anywhere in the body, invades the lining of the lower part of the small intestine and the large intestine. Here, the candida sets up residence in the warmth and the dark, and demands to be fed. Loving sugars and starches, candida can make you suffer terrible sweet cravings. Candida can produce toxins which can cause very many symptoms of exhaustion, headache, general illness, and which interfere with the uptake of thyroid and adrenal treatment. Sometimes the levels - which we usually test for - can be very high, and make successful treatment difficult to achieve until adequately treated. Then there is receptor resistance which could be a culprit. Being hypothyroid for some considerable time may mean the biochemical mechanisms which permit the binding of T3 to the receptors, is downgraded - so the T3 won’t go in. With slow build up of T3, with full adrenal support and adequate vitamins and minerals, the receptors do come on line again. But this can be quite a slow process, and care has to be taken to build the dose up gradually. And then there are Food allergies. The most common food allergy is allergy to gluten, the protein fraction of wheat. The antibody generated by the body, by a process of molecular mimicry, cross reacts with the thyroperoxidase enzyme, (which makes thyroxine) and shuts it down. So allergy to bread can make you hypothyroid. There may be other food allergies with this kind of effect, but information on these is scanty. Certainly allergic response to certain foods can affect adrenal function and imperil thyroid production and uptake. Then we have hormone imbalances. The whole of the endocrine system is linked; each part of it needs the other parts to be operating normally to work properly. An example of this we have seen already, with cortisone. But another example is the operation of sex hormones. The imbalance that occurs at the menopause with progesterone running down, and a relative dominance of oestrogen is a further case in point – oestrogen dominance downgrades production, transportation and uptake of thyroid hormones. This is why hypothyroidism may first appear at the menopause; the symptoms ascribed to this alone, which is then treated – often with extra oestrogen, making the whole thing worse. Deficiency in progesterone most especially needs to be dealt with, since it reverses oestrogen dominance, improves many menopausal symptoms like sweats and mood swings, and reverses osteoporosis. Happily natural progesterone cream is easily obtained: when used it has the added benefit of helping to stabilise adrenal function. Then, we must never forget the possibility of mercury poisoning (through amalgam fillings) - low levels of iron, ferritin, vitamin B12, vitamin D3, magnesium, folate, copper and zinc - all of which, if low, stop the thyroid hormone from being utilised by the cells - these have to be treated. Your sister should ask her GP to test these specific minerals/vitamins and if s/he says that there is no connection between these and low thyroid, tell her to copy out the references below to show that there is. As Dr Peatfield says " When you have been quite unwell for a long time, all these problems have to be dealt with; and since each may affect the other, it all has to be done rather carefully. Contrary to cherished beliefs by much of the medical establishment, the correction of a thyroid deficiency state has a number of complexities and variables, which make the treatment usually quite specific for each person. The balancing of these variables is as much up to you as to me – which is why a check of morning, day and evening temperatures and pulse rates, together with symptoms, good and bad, can be so helpful. Many of you have been ill for a long time, either because you have not been diagnosed, or the treatment leaves you still quite unwell. Those of you who have relatively mild hypothyroidism, and have been diagnosed relatively quickly, may well respond to synthetic thyroxine, the standard treatment. I am therefore unlikely to see you; since if the thyroxine proves satisfactory in use, it is merely a question of dosage. For many of you, the outstanding problem is not that the diagnosis has not been made – although, extraordinarily, this is disgracefully common – but that is has, and the thyroxine treatment doesn’t work. The dose has been altered up and down, and clinical improvement is variable and doesn’t last, in spite of blood tests, which say you are perfectly all right (and therefore you are actually depressed and need this fine antidepressant). The above problems must be eliminated if thyroid hormone isn't working for you. Luv - Sheila References to specific minerals/vitamins and the thyroid connection: Low iron/ferritin: Iron deficiency is shown to significantly reduce T4 to T3 conversion, increase reverse T3 levels, and block the thermogenic (metabolism boosting) properties of thyroid hormone (1-4). Thus, iron deficiency, as indicated by an iron saturation below 25 or a ferritin below 70, will result in diminished intracellular T3 levels. Additionally, T4 should not be considered adequate thyroid replacement if iron deficiency is present (1-4)). 1. Dillman E, Gale C, Green W, et al. Hypothermia in iron deficiency due to altered triiodithyroidine metabolism. Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381. 2. SM, PE, Lukaski HC. In vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of dietary fat. Life Sci 1993;53(8):603-9. 3. Zimmermann MB, Köhrle J. The Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to Public Health. Thyroid 2002;12(10): 867-78. 4. Beard J, tobin B, Green W. Evidence for Thyroid Hormone Deficiency in Iron-Deficient Anemic Rats. J. Nutr. 1989;119:772-778. Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403 Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329 and http://www.goodhormonehealth.com/VitaminD.pdf Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738 and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163 Low copper http://www.ithyroid.com/copper.htm http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm http://www.ithyroid.com/copper.htm http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf http://ajplegacy.physiology.org/content/171/3/652.extract Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html I am writing on behalf of my sister who has been taking T4 for 5 months after having her thyroid removed. She has been on doses of 125, 100, 75 and now 150. All does have had the same result of basically turning her practically insane. She can't remember or recognise where she lives. Not even her own apartment. But now that she is on 150 dosage she is also has a resting heart rate of 95 per minute. When previously it was 64. She is too scared to come off the synthetic T4 as she thinks she will instantly fall into a coma. Yet her whole life is falling apart while she continues to take it. She now has to be supervised 24/7. We are waiting for the Armour to arrive. But I already have some dissicated porcine capsules from Nutri-med.com that contains T1 T2 T3 and T4. But I have read in places that it is much weaker than Armour. Maybe about 4 times weaker. Has anyone used the nutri-meds product with success. Is it safe to come off T4 and go onto nutrimeds. I have already had her on the Adrenal support for a few days in preparation for Armour or Nutrimeds. Our worry is that because the Nutri-meds is weak that coming of the T$ and going onto the Nutri-meds might no provide enough or the hormone to keep her safe. Please advise. There is also another product called Thyro-Gold. Apparently this is stronger than the nutri-med product and about the same as Armour. Please advise. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 22, 2011 Report Share Posted September 22, 2011 Thank you for the reply. Actually I do not have the hypothyrodism. Its is my sister who does. But she is so mentally affected that she cannot post in the forum. In her case the thyroid has been removed. So is fully dependent on a thyroid substitute of some kind. But I am trying to compare. Erfa with Thyroid Gold and Nutri-Meds Dessicated Pocine Capcules, in terms of strengh and dose. I am waiting for the Erfa Thyroid to arrive, but I already have the Nutri-Meds one. But she is too scared to take it without seeing a Doctor first. Here own doctors are totally useless. The have never even heard of Armour and would not prescribe it as it is not in there database. I tried to contact Dr Peatfield but he is on holiday this weak. Can you send me the contact details for Dr Skinner please. > > Who on earth is looking after your sister and can you let us have the > results of recent thyroid function tests together with the reference range > for each test done. Has she been tested to see whether she has thyroid > antibodies (TPO, TgAb) especially as you too have hypothyroidism. If not, > she must get tested to see if she has Hashimoto's disease. If she has > antibodies, she should know that antibodies thrive on gluten so if she is > eating a diet high in gluten, she might wish to consider going on a gluten > free diet. > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2011 Report Share Posted September 24, 2011 > > I tried to contact Dr Peatfield but he is on holiday this weak. Can you send me the contact details for Dr Skinner please. > You must be so very worried. I cannot advise you I'm afraid as my situtation is very different, but you obviously need advice now. It seems that the way to draw attention to a query that goes unnoticed is to type BUMPING in the message line and post your question again. Yous sister's plight clearly needs very urgent attention, so why not try posting again? All the best to you and your sister. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2011 Report Share Posted September 24, 2011 Hi What is your name,first of all? And your sister's? Are you saying that each and every dose of T4 has had exactly the same effect on your sister, ie, 75mcg does the same as 150mcg? I wonder what is going on there. Can you advise what brand of T4 she is taking? I wonder if she allergic to something in it. Allergies can mess things up big time. How was your sister before the removal of thyroid? are you saying her healht was fine before that? Why was her thyroid removed? have you researched adrenal problems, could that be a reason why your sistr is having these problems? Without cortisol support, my mind suffers. Has your sister been checked for adrenal antibodies? > Has anyone used the nutri-meds product with success. Is it safe to come off T4 and go onto nutrimeds. I have already had her on the Adrenal support for a few days in preparation for Armour or Nutrimeds. you need to find out what is going on here - with the Armour, T4, etc, you know exactly what is in them, but as far as i'm concerned, it could be any amount of t4 or t3 or t2 (or nothing) in the other supplements. > Our worry is that because the Nutri-meds is weak that coming of the T$ and going onto the Nutri-meds might no provide enough or the hormone to keep her safe. Please advise. What does her GP say? First things i'd check is is this an allergy to something in the meds, and are her adrenals ok? It says on thyroid meds not to take them if you have adrenal problems. I would consult the gp and ask about both asap. do her symptoms fit adrenal issues? (i mean when you say she's going practically insane) Chris Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 24, 2011 Report Share Posted September 24, 2011 Dr Skinner's details are on here, but he'll need a referral, and don't think he'll treat or test adrenal problems chris http://www.thyroid-info.com/topdrs/unitedkingdom.htm > I tried to contact Dr Peatfield but he is on holiday this weak. Can you send me the contact details for Dr Skinner please. > Quote Link to comment Share on other sites More sharing options...
Guest gabbymom Posted August 23, 2013 Report Share Posted August 23, 2013 She is probably on the verge of hashimoto's encephelopy or mydexema coma. Either Is dangerous. Probably more likely not encephelopy because the thyroid has been removed. She is experiencing increased slowing in her brain because she is not coverting the t4 into t3. T3 is the only thing our body can use. She needs to get on a natural thyroid quickly. No glandulars No nutrimeds no thyro gold etc. She will need Armour thyroid I'm quessing a dose of 120 mg or more. and Asap. Call and find a doctor who is willing to prescribe. Quote Link to comment Share on other sites More sharing options...
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