hypothyroidism

June 3, 2001

I lost 30 lbs and was/am still hypothyroid. Free T3 was low originally, then

Free T4 became low. Still playing around with meds. I too was/am severely

constipated. And I ate like a horse. Think it might be from malabsorption.

Donna in NC

Hypothyroidism

> I just read an article on Hypothyroidism and how it is

> underdiagnosed partly because most docs don't do the

> proper testing. The only symptom that didn't fit me was

> excessive weight gain. I have dropped about 20 lbs. since

> getting CFS (?) in 1993. However, I did gain about 15 lbs.

> in the first year, and then the constipation (which is a

> symptom of hypothyroidism) has pretty much caused me to lose

> 35 lbs. from my peak weight in 1994.

>

> The question is, does anyone know if weight loss can occur

> if one has hypothyroidism? It would seem to me that if lack

> of GI motility due to hypoT caused one to be unable to eat

> much, weight loss could occur.

>

> Mike

June 4, 2001

I also have hypothyroidism and CFS. Yes, you can loose weight. Although it's

not typical. I am also one of those who lost weight. Weight gain or loss is

not diagnostic in and of itself.

Hypothyroidism

I just read an article on Hypothyroidism and how it is

underdiagnosed partly because most docs don't do the

proper testing. The only symptom that didn't fit me was

excessive weight gain. I have dropped about 20 lbs. since

getting CFS (?) in 1993. However, I did gain about 15 lbs.

in the first year, and then the constipation (which is a

symptom of hypothyroidism) has pretty much caused me to lose

35 lbs. from my peak weight in 1994.

The question is, does anyone know if weight loss can occur

if one has hypothyroidism? It would seem to me that if lack

of GI motility due to hypoT caused one to be unable to eat

much, weight loss could occur.

Mike

June 4, 2001

I think you're right.

Hypothyroidism

> I just read an article on Hypothyroidism and how it is

> underdiagnosed partly because most docs don't do the

> proper testing. The only symptom that didn't fit me was

> excessive weight gain. I have dropped about 20 lbs. since

> getting CFS (?) in 1993. However, I did gain about 15 lbs.

> in the first year, and then the constipation (which is a

> symptom of hypothyroidism) has pretty much caused me to lose

> 35 lbs. from my peak weight in 1994.

>

> The question is, does anyone know if weight loss can occur

> if one has hypothyroidism? It would seem to me that if lack

> of GI motility due to hypoT caused one to be unable to eat

> much, weight loss could occur.

>

> Mike

March 25, 2002

Rich - very interesting theory! My thyroid tested at

the low end of normal for years, but I had all the

classic hypothyroid symptoms, so finally my current

wonderful doctor put me on hormones and I had a huge

immediate improvement. It didn't cure me, but what a

difference! I think your theory is spot on.

Jennie F.

Message: 1

Date: Sat, 23 Mar 2002 00:50:14 -0000

From: " rvankon " <vankonynenburg1@...>

Subject: Hypothyroid, Krebs cycle blocks, and RNase-L

Hi, all.

I'd like to share some thoughts for your

consideration.

Quite a few PWCs have reported that when their thyroid

hormones were

tested, they came out normal, but if they went ahead

and took

supplementary thyroid hormones anyway, they

experienced benefits in

their symptomatology, in terms of feeling warmer and

having more

energy. If this has been or has not been people's

experience, I would

like to hear about it.

In the past, I suggested that what was going on was

that these PWCs

had partial blockades in their Krebs cycles because of

inhibition of

aconitase by peroxynitrite, secondary to depletion of

their reduced

glutathione (which in turn was driven by a combination

of various

kinds of stressors and perhaps influenced by a genetic

predisposition

and dietary inadequacies). I suggested that the

increase in thyroid

hormones was partially compensating for this by

inducing the

production of more enzymes, including aconitase, so

that even though

their thyroid hormone levels appeared to be in the

normal ranges, they

benefited by raising them above the normal ranges

because it helped to

counter something else that was abnormal, i.e., the

amount of active

aconitase enzyme.

Upon viewing the latest video of Dr. Cheney, it struck

me that another

mechanism may be going on, also, as follows. We know

that many PWCs

have a high activity in their RNase-L pathway, and Dr.

Cheney has

stressed that this causes an across-the-board

breakdown of messenger

RNA, including not only the messenger RNA that

supports the production

of proteins needed by the virus, but also the proteins

needed by the

cell for normal operation, presumably including the

enzymes used in

the Krebs cycle. The result is a general slowing of

the metabolism of

the cell. It occurs to me that adding thyroid

hormones in this

situation could partially compensate for this slowing

produced by the

RNase-L, because the way thyroid hormones operate is

to go to the

nucleus of the cell and promote gene expression, i.e.

the production

of messenger RNA. So maybe the thyroid hormones are

acting to counter

the effect of the RNase-L as well as to counter the

effect of

peroxynitrite on producing partial blockades in the

Krebs cycles.

So what? Well, it would of course be better to figure

out how to

switch off the overactive Rnase-L pathway rather than

just to oppose

it by making messenger RNA faster than this pathway

can destroy it. I

guess that's what Ampligen does, but as you know

that's very expensive

and hard to get right now. (And I think it's

important to knock out

the virus and get the Th1 immune response back up to

speed to take

over the fight against the virus from the Rnase-L

pathway before you

shut this pathway down, or the virus will run

rampant.) In the

meantime, maybe there's a basis here for the so-called

's

syndrome (not the same as 's disease), and a

justification for

the use of the 's syndrome remedy in CFS

(supplementary

timed-release T3). I've always wondered where this

fits in, and maybe

this is the place. I would appreciate any comments.

Rich

__________________________________________________

March 25, 2002

F.,

Thanks for sharing your experience. I'm glad the thyroid hormones

helped you out.

Rich

> Rich - very interesting theory! My thyroid tested at

> the low end of normal for years, but I had all the

> classic hypothyroid symptoms, so finally my current

> wonderful doctor put me on hormones and I had a huge

> immediate improvement. It didn't cure me, but what a

> difference! I think your theory is spot on.

>

> Jennie F.

March 26, 2002

F.,

Thanks for the response. I'm glad the thyroid hormones helped you.

Rich

December 15, 2002

I have Hypothyroidism. I go to an endocrinologist. The key is getting your

levels regulated. Too much meds are dangerous-They don't speed up your

metabolism and can make you more prone to osteoporosis.

I don't work any harder then other folks, but I work hard just as they do.

CAli

http://pages.sbcglobal.net/tracyla2

Hypothyroidism

Just curious if anyone else out there has Hypothyroidism and notices

a much slower metabolism? I just finished reading an interesting

article in Oxygen Fitness about a bodybuilder who has it. She talks

about how she has to do much more cardio to get the weight off and

be very strict with her diet. She doesn't really do cheat days -

her cheats are a bananna and raisens. I also have to do alot of

cardio otherwise I notice the weight creeps up. Right now I do 50-

60 min 5-6 days a week. I had dropped my weight training to three

45+ min sessions per recommendation from a trainer - but found I

started to notice I was losing definition and body fat was

increasing. So now I do at least four 45+ min weightlifting in

addition to the cardio. I do need to be stricter with the diet as I

tend to fall off occassionally. But just was curious if anyone else

with this disease has the same problem? I just figured it was

me...I was glad to read that article and find out there is someone

else who has the same problem.

December 15, 2002

I don't have hypothyroidism, but I've just had like 2 liters of Diet Vanilla

Coke and I can't quit typing. :-)

I was just going to ask if your cardio includes 15-20 minutes of intense

intervals three times a week in addition to the longer sessions? The high

intensity interval training really helps kick up your fat loss. If the intervals

are intense enough, you can't do it every day or for very long. It's an

important part of getting lean though. So, like you could throw up a lung for 20

minutes and then continue the rest of the session with moderate cardio.

HIIT

http://www.musclemedia.com/training/hiit.asp

Also, be careful when doing that much cardio that you're crosstraining and

throwing in some low-impact sessions. Your biggest risk is overtraining or

overuse injuries.

Another thing you might consider trying is circuit training. I do some workouts

that alternate weight stations with intense cardio intervals. It's not for

everybody but it's a massive calorie burn if that's the kind of thing you're

looking for.

Burn Out Circuit

http://skwigg.tripod.com/wow/id14.html

....was it Susie Currie who has hypothyroidism? I can never remember.