Crashed on erfa

[Guest guest]

Things were going so well,I gently increased the erfa whilst decreasing the

thyroxine and I was feeling very hopefull and definitely better.

Then I've crashed big time with extreme anxiety and m.e symptoms .what do I do

now?

[Guest guest]

Hello

Read

the following information and go through each one of therse by way of a process

of elimination to find out what might have caused you to crash:

There

are MANY reasons and many medical conditions associated with thyroid disease

that stop thyroid hormone from getting into the cells, where it does its work.

I mention these over and over and over again - ad nauseum - people must be

bored with the same old, same old but as each new member joins us, they need to

know.

The

main condition responsible for stopping thyroid hormone from working, is, quite

simply, a patients thyroxine dose is too low because the doctor or consultant

refuses to increase it, because the serum thyroid function test results appear

OK. Sometimes, the thyroxine dose is too high, yet patients still don't feel

well. They continue to suffer. Some reasons for this:

They

may be suffering with low adrenal reserve. The production of T4, its conversion

to T3, and the receptor uptake requires a normal amount of adrenal hormones,

notably, of course, cortisone. (Excess cortisone can shut production down,

however.) This is what happens if the adrenals are not responding properly, and

provision of cortisone usually switches it on again. But sometimes it

doesn’t. If the illness has been going on for a long time, the

enzyme seems to fail. This conversion failure (inexplicably denied by

many endocrinologists) means the thyroxine builds up, unconverted. So it

doesn’t work, and T4 toxicosis results. This makes the patient feel quite

unwell, toxic, often with palpitations and chest pain. If provision of adrenal

support doesn’t remedy the situation, the final solution is the use of

the active thyroid hormone, already converted, T3 - either synthetic or

natural.

Then,

we have systemic candidiasis. This is where candida albicans, a yeast, which

causes skin infections almost anywhere in the body, invades the lining of the

lower part of the small intestine and the large intestine. Here, the

candida sets up residence in the warmth and the dark, and demands to be

fed. Loving sugars and starches, candida can make you suffer terrible

sweet cravings. Candida can produce toxins which can cause very many

symptoms of exhaustion, headache, general illness, and which interfere with the

uptake of thyroid and adrenal treatment. Sometimes the levels - which we

usually test for - can be very high, and make successful treatment difficult to

achieve until adequately treated.

Then

there is receptor resistance which could be a culprit. Being hypothyroid

for some considerable time may mean the biochemical mechanisms which permit the

binding of T3 to the receptors, is downgraded - so the T3 won’t go

in. With slow build up of T3, with full adrenal support and adequate

vitamins and minerals, the receptors do come on line again. But this can

be quite a slow process, and care has to be taken to build the dose up

gradually.

And

then there are Food allergies. The most common food allergy is allergy to

gluten, the protein fraction of wheat. The antibody generated by the body, by a

process of molecular mimicry, cross reacts with the thyroperoxidase enzyme,

(which makes thyroxine) and shuts it down. So allergy to bread can make

you hypothyroid. There may be other food allergies with this kind of effect,

but information on these is scanty. Certainly allergic response to

certain foods can affect adrenal function and imperil thyroid production and

uptake.

Then

we have hormone imbalances. The whole of the endocrine system is linked; each

part of it needs the other parts to be operating normally to work

properly. An example of this we have seen already, with cortisone.

But another example is the operation of sex hormones. The imbalance that

occurs at the menopause with progesterone running down, and a relative

dominance of oestrogen is a further case in point – oestrogen dominance

downgrades production, transportation and uptake of thyroid hormones.

This is why hypothyroidism may first appear at the menopause; the symptoms

ascribed to this alone, which is then treated – often with extra

oestrogen, making the whole thing worse. Deficiency in progesterone most

especially needs to be dealt with, since it reverses oestrogen dominance,

improves many menopausal symptoms like sweats and mood swings, and reverses

osteoporosis. Happily natural progesterone cream is easily obtained: when

used it has the added benefit of helping to stabilise adrenal function.

Then,

we must never forget the possibility of mercury poisoning (through amalgam

fillings) - low levels of ferritin, vitamin B12, vitamin D3, magnesium, folate,

copper and zinc - all of which, if low, stop the thyroid hormone from being

utilised by the cells - these have to be treated. Ask your GP to test each one

of these and when you have the results post them on the forum together with the

reference range. If your GP tries to tell you there is no connection between

these low levels and hypothyroidism, them copy out the references to just some

of the research and studies done to show that there is. See below (*****)

As

Dr Peatfield says " When you have been quite unwell for a long time, all

these problems have to be dealt with; and since each may affect the other, it

all has to be done rather carefully.

Contrary

to cherished beliefs by much of the medical establishment, the correction of a

thyroid deficiency state has a number of complexities and variables, which make

the treatment usually quite specific for each person. The balancing of

these variables is as much up to you as to me – which is why a check of

morning, day and evening temperatures and pulse rates, together with symptoms,

good and bad, can be so helpful.

Many

of you have been ill for a long time, either because you have not been

diagnosed, or the treatment leaves you still quite unwell. Those of you

who have relatively mild hypothyroidism, and have been diagnosed relatively

quickly, may well respond to synthetic thyroxine, the standard treatment.

I am therefore unlikely to see you; since if the thyroxine proves satisfactory

in use, it is merely a question of dosage.

For

many of you, the outstanding problem is not that the diagnosis has not been

made – although, extraordinarily, this is disgracefully common –

but that is has, and the thyroxine treatment doesn’t work. The dose

has been altered up and down, and clinical improvement is variable and

doesn’t last, in spite of blood tests, which say you are perfectly all

right (and therefore you are actually depressed and need this fine

antidepressant).

The

above problems must be eliminated if thyroid hormone isn't working for you.

(****) Things were going so

well,I Low iron/ferritin: Iron deficiency is shown to significantly reduce T4

to T3 conversion, increase reverse T3 levels, and block the thermogenic

(metabolism boosting) properties of thyroid hormone (1-4). Thus, iron

deficiency, as indicated by an iron saturation below 25 or a ferritin below 70,

will result in diminished intracellular T3 levels. Additionally, T4 should not

be considered adequate thyroid replacement if iron deficiency is present (1-4)).

1.

Dillman E, Gale C, Green W, et al. Hypothermia in iron

deficiency due to altered triiodithyroidine metabolism. Regulatory, Integrative

and Comparative Physiology 1980;239(5):377-R381.

2.

SM, PE, Lukaski HC. In vitro hepatic

thyroid hormone deiodination in iron-deficient rats: effect of dietary fat.

Life Sci 1993;53(8):603-9.

3.

Zimmermann MB, Köhrle J. The Impact of Iron and Selenium

Deficiencies on Iodine and Thyroid Metabolism: Biochemistry and Relevance to

Public Health. Thyroid 2002;12(10): 867-78.

4.

Beard J, tobin B, Green W. Evidence for Thyroid Hormone

Deficiency in Iron-Deficient Anemic Rats. J. Nutr. 1989;119:772-778.

Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403

Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329

and http://www.goodhormonehealth.com/VitaminD.pdf

Low magnesium:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf

Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738

and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163

Low  copper http://www.ithyroid.com/copper.htm

http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm

http://www.ithyroid.com/copper.htm

http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf

http://ajplegacy.physiology.org/content/171/3/652.extract

Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf

and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html

Luv - Sheila

 gently increased the erfa whilst decreasing

the thyroxine and I was feeling very hopefull and definitely better.

Then I've crashed big time with extreme anxiety and m.e symptoms .what do I do

now?

[Guest guest]

does anyone have any ideas why this would happen 12 weeks down the line?ive had

a fab 12 weeks and now im so ill again.

should i stop the erfa or just back off a dose?

>

> Things were going so well,I gently increased the erfa whilst decreasing the

thyroxine and I was feeling very hopefull and definitely better.

>

> Then I've crashed big time with extreme anxiety and m.e symptoms .what do I do

now?

>

>

[Guest guest]

Hi

I took quite some time to write a response to your first

message. Have you not read it - here it is again?

Hello

Read the following information and go through each one

of these by way of a process of elimination to find out what might have caused

you to crash:

There are MANY reasons and many medical conditions

associated with thyroid disease that stop thyroid hormone from getting into the

cells, where it does its work. I mention these over and over and over again -

ad nauseum - people must be bored with the same old, same old but as each new

member joins us, they need to know.

The main condition responsible for stopping thyroid

hormone from working, is, quite simply, a patients thyroxine dose is too low

because the doctor or consultant refuses to increase it, because the serum

thyroid function test results appear OK. Sometimes, the thyroxine dose is too

high, yet patients still don't feel well. They continue to suffer. Some

reasons for this:

They may be suffering with low adrenal reserve. The

production of T4, its conversion to T3, and the receptor uptake requires a

normal amount of adrenal hormones, notably, of course, cortisone. (Excess

cortisone can shut production down, however.) This is what happens if the

adrenals are not responding properly, and provision of cortisone usually

switches it on again. But sometimes it doesn’t. If the

illness has been going on for a long time, the enzyme seems to fail. This

conversion failure (inexplicably denied by many endocrinologists) means the

thyroxine builds up, unconverted. So it doesn’t work, and T4

toxicosis results. This makes the patient feel quite unwell, toxic, often with

palpitations and chest pain. If provision of adrenal support doesn’t

remedy the situation, the final solution is the use of the active thyroid

hormone, already converted, T3 - either synthetic or natural.

Then, we have systemic candidiasis. This is where

candida albicans, a yeast, which causes skin infections almost anywhere in the

body, invades the lining of the lower part of the small intestine and the large

intestine. Here, the candida sets up residence in the warmth and the

dark, and demands to be fed. Loving sugars and starches, candida can make

you suffer terrible sweet cravings. Candida can produce toxins which can

cause very many symptoms of exhaustion, headache, general illness, and which

interfere with the uptake of thyroid and adrenal treatment. Sometimes the

levels - which we usually test for - can be very high, and make successful

treatment difficult to achieve until adequately treated.

Then there is receptor resistance which could be a

culprit. Being hypothyroid for some considerable time may mean the

biochemical mechanisms which permit the binding of T3 to the receptors, is

downgraded - so the T3 won’t go in. With slow build up of T3, with

full adrenal support and adequate vitamins and minerals, the receptors do come

on line again. But this can be quite a slow process, and care has to be

taken to build the dose up gradually.

And then there are Food allergies. The most common

food allergy is allergy to gluten, the protein fraction of wheat. The antibody

generated by the body, by a process of molecular mimicry, cross reacts with the

thyroperoxidase enzyme, (which makes thyroxine) and shuts it down. So

allergy to bread can make you hypothyroid. There may be other food allergies

with this kind of effect, but information on these is scanty. Certainly

allergic response to certain foods can affect adrenal function and imperil

thyroid production and uptake.

Then we have hormone imbalances. The whole of the

endocrine system is linked; each part of it needs the other parts to be

operating normally to work properly. An example of this we have seen

already, with cortisone. But another example is the operation of sex

hormones. The imbalance that occurs at the menopause with progesterone

running down, and a relative dominance of oestrogen is a further case in point

– oestrogen dominance downgrades production, transportation and uptake of

thyroid hormones. This is why hypothyroidism may first appear at the

menopause; the symptoms ascribed to this alone, which is then treated –

often with extra oestrogen, making the whole thing worse. Deficiency in

progesterone most especially needs to be dealt with, since it reverses

oestrogen dominance, improves many menopausal symptoms like sweats and mood

swings, and reverses osteoporosis. Happily natural progesterone cream is easily

obtained: when used it has the added benefit of helping to stabilise adrenal

function.

Then, we must never forget the possibility of mercury

poisoning (through amalgam fillings) - low levels of ferritin, vitamin B12,

vitamin D3, magnesium, folate, copper and zinc - all of which, if low, stop the

thyroid hormone from being utilised by the cells - these have to be treated.

Ask your GP to test each one of these and when you have the results post them

on the forum together with the reference range. If your GP tries to tell you

there is no connection between these low levels and hypothyroidism, them copy

out the references to just some of the research and studies done to show that

there is. See below (*****)

As Dr Peatfield says " When you have been quite

unwell for a long time, all these problems have to be dealt with; and since

each may affect the other, it all has to be done rather carefully.

Contrary to cherished beliefs by much of the medical

establishment, the correction of a thyroid deficiency state has a number of

complexities and variables, which make the treatment usually quite specific for

each person. The balancing of these variables is as much up to you as to

me – which is why a check of morning, day and evening temperatures and

pulse rates, together with symptoms, good and bad, can be so helpful.

Many of you have been ill for a long time, either

because you have not been diagnosed, or the treatment leaves you still quite

unwell. Those of you who have relatively mild hypothyroidism, and have

been diagnosed relatively quickly, may well respond to synthetic thyroxine, the

standard treatment. I am therefore unlikely to see you; since if the

thyroxine proves satisfactory in use, it is merely a question of dosage.

For many of you, the outstanding problem is not that

the diagnosis has not been made – although, extraordinarily, this is

disgracefully common – but that is has, and the thyroxine treatment

doesn’t work. The dose has been altered up and down, and clinical

improvement is variable and doesn’t last, in spite of blood tests, which

say you are perfectly all right (and therefore you are actually depressed and

need this fine antidepressant).

The above problems must be eliminated if thyroid

hormone isn't working for you.

(****) Things were going so well,I Low iron/ferritin: Iron

deficiency is shown to significantly reduce T4 to T3 conversion, increase

reverse T3 levels, and block the thermogenic (metabolism boosting) properties

of thyroid hormone (1-4). Thus, iron deficiency, as indicated by an iron

saturation below 25 or a ferritin below 70, will result in diminished

intracellular T3 levels. Additionally, T4 should not be considered adequate

thyroid replacement if iron deficiency is present (1-4)).

1.

Dillman E, Gale C, Green W, et al.

Hypothermia in iron deficiency due to altered triiodithyroidine metabolism.

Regulatory, Integrative and Comparative Physiology 1980;239(5):377-R381.

2.

SM, PE, Lukaski HC.

In vitro hepatic thyroid hormone deiodination in iron-deficient rats: effect of

dietary fat. Life Sci 1993;53(8):603-9.

3.

Zimmermann MB, Köhrle J. The

Impact of Iron and Selenium Deficiencies on Iodine and Thyroid Metabolism:

Biochemistry and Relevance to Public Health. Thyroid 2002;12(10): 867-78.

4.

Beard J, tobin B, Green W.

Evidence for Thyroid Hormone Deficiency in Iron-Deficient Anemic Rats. J. Nutr.

1989;119:772-778.

Low vitamin B12: http://www.ncbi.nlm.nih.gov/pubmed/18655403

Low vitamin D3: http://www.eje-online.org/cgi/content/abstract/113/3/329

and http://www.goodhormonehealth.com/VitaminD.pdf

Low magnesium: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC292768/pdf/jcinvest00264-0105.pdf

Low folate: http://www.clinchem.org/cgi/content/full/47/9/1738

and http://www.liebertonline.com/doi/abs/10.1089/thy.1999.9.1163

Low copper http://www.ithyroid.com/copper.htm

http://www.drlwilson.com/articles/copper_toxicity_syndrome.htm

http://www.ithyroid.com/copper.htm

http://www.rjpbcs.com/pdf/2011_2(2)/68.pdf

http://ajplegacy.physiology.org/content/171/3/652.extract

Low zinc:http://www.istanbul.edu.tr/ffdbiyo/current4/07%20Iham%20AM%C4%B0R.pdf

and http://articles.webraydian.com/article1648-Role_of_Zinc_and_Copper_in_Effective_Thyroid_Function.html

Luv - Sheila

From: thyroid treatment

[mailto:thyroid treatment ] On Behalf Of

Sent: 22 September 2011 07:19

thyroid treatment

Subject: Re: Crashed on erfa

does anyone have any ideas why this would

happen 12 weeks down the line?ive had a fab 12 weeks and now im so ill again.

should i stop the erfa or just back off a dose?

>

> Things were going so well,I gently increased the erfa whilst decreasing

the thyroxine and I was feeling very hopefull and definitely better.

>

> Then I've crashed big time with extreme anxiety and m.e symptoms .what do

I do now?

>

>

[Guest guest]

Hi , have you managed to get rid of the candida problem which you mentioned

some time back? How's that going?

Miriam

> I took quite some time to write a response to your first message. Have you not

read it - here it is again?