Hello new member here....

[Guest guest]

Hello all,

Just a quick intro about me.

I am a 35 year old man, currently a patient of Dr peatfield and have been suffering severely for the past 6-7 years but i believe i have had adrenal issues now for a while only i never realised. I have some questions in amongst my intro if anyone can help it would be brilliant.

I beleive it all started with me using beconase corticosteroid sprays doctor gave for nasal allergies as a child and i remember as a 13 year old feeling weak and fatigued, I would get dizzy if i stood up too fast etc etc. Looking back i can now fit the pieces of the puzzle. Through 15 - 22 i was fine as i know fine to be - energy good, fanatstic libido, good mood, excellent mental processing, strength, stamina overall pretty healthy and fit as would be expacted at a young age. At 22 i got a severe chest inflammation after an infection and got prescribed prednisone. I tapered down as i was told but thinking back after this i was never right. I can remember the midday fatigue, slight depression and brain fog started around that sort of age which was not so bad back then but i noticed it was present, i also was taking soya protien powders in large amounts as i am lactose intolerant and felt i needed extra for

going to gym. This is the time my health detriorated. I now know soya is harmful to thyroid. luckily i stopped soya protien powders after about a year of taking them. I plodded along with life which got stressful as time went on and i noticed gradual worsening of symptoms over the next 5- 6 years. Libido decreased, mood was not as hood, energy was down, midday i would fall asleep especially after eating, if i had not slept and awaoke naturally or as fully as atleast 8 hours i would suffer. weekends i was fine, holidays when i could slep in i was fine, but if i had to cut sleep short then i was feeling it.

At 28 i got a spot of hives and doc presribed prednisone but only at 5 mg for a week. Told me i did not need to taper. That week i became like my old self for the first time in maybe 6 years. Libido was up like i remembered, energy and mood was good and i felt really good and had forgotten i had felt like this once, it was a holiday too and i noticed it more and thought maybe its the drug effects and not natural. Once the week was over i was busy back at work and did not pay attention to how i felt, but noticed my libido was now lower than before i took prednisone. I did not know what happened or what to make of it.

at around 29 i suffered stress and started suffering from insomnia where i would awake after 3- 4 hours and feel panicky. I became depressed started stressing over everything and anything, my calm mind had gone and i started having anxiety attacks. Thinking back even when i was around 24- 26 i would go to bed all tense and anxious and suffer bouts of depression, only now depression got real bad so these symptoms were there only not so noticeable, i would have bouts of anxiety just take me over and repetitive thoughts runa round in my head constantly and became overly negative. I can count on one hand when i have had normal sleep over 6- 7 years! I went a whole 5 years barely sleeping 3- 4 hours and would awake all wired and alert would be so fatigued midday but had to keep going ebcause of work. This was hell and i struggled through it with caffiene which would barely keep me going, then at evenings i could not sleep til late and

whenh i did i would awake early all alert and unable to sleep.

Doctors could not work out what was wrong and gave me prozac, i came home and was going to take them but binned them and decided to try alternative medicine, which hardly helped me. I lie, maybe they did, enough to keep me awake and allow me to function but still no deep refreshing sleep. Infact i have a case of heavy metal poisoning due to this which is being dealt with and i will see doc next week and go for chelation. Anyway my sleep got better with a reduction of stress but never deep and long like before. i still had poor libido, energy and mood. I feel unwell and never rested.

I saw Dr peatfield on the web and was desperate so i gave him a try. He put me on nutrimeds but i said i did not want to take them and we agreed on Isocort. Just the one isocort calmed down my anxiety and made me feel normal. My mother is ill and it helped her too. This was amazing, then it would wear off slowly but the effect lasted all day. This allowed me to function at work where i was keeping up barely with struggle.

i am now up to 8 pellets a day and i can function, however i still have no libido or very very poor fleeting moments of it and my sleep is still not excellent but i can function now and have enough energy not to get too fatigued. I noticed my nose is getting oily again and is sebum production is a good thing? i noticed my facial skin had become very dry when it used to be oily before. My bodytemp on a morning will be around 35.5 and pulse will be around 65 - 70 but jumps to around 80 most days around midday. My bodytemp has not gone up past 36 in mornings, fluctuates around 35- 5 - 35.8. However around 3:00 it shoots up to around 36.5 to 36.8. I also notice a tickle in my throat recently and it makes me cough and when i smile widely and tilt my head back it seems like my throat is touching against something, like something is touching against my windpipe. I have suspected lead posioning from takeing herbal stuff, maybe teh lead swells the

thyroid? Maybe i have thyroid issues that need sorting or maybe i need more isocort to kick start the thyroid, anyone got ideas?. I have a feeling i may have reverse T3 or s syndrome due to the obscene amount of stres and mental strain i have been under. I am seeing Dr Peatfield soon anyway and i will ask, he is a legend and i wish him a long healthy and happy life so he can keep up the good work. I now wish i can get back to being normal, whatever that will be for my age, i know normal is not how i am now, i only remember feeling normal at 20 so i dont know what to expect now 15 years later.

Thanks to shelia for creating this resource so that we can regain our health.

Best regards

Mohammed

From: Sheila <sheila@...>thyroid treatment Sent: Sun, 20 February, 2011 12:07:15Subject: Possible genetic marker

A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters; including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement.

P, Panicker V, Sayers A, Shields B, Iqbal A, Bremner A, Beilby J, Leedman P, Hattersley A, Vaidya B, Frayling T, J, Tobias JH, Timpson NJ, Walsh

JP, Dayan CM.

P , Henry Wellcome Labarotories for Integrative Neuroscience and Endocrinology, University of Bristol, Bristol, United Kingdom.

Abstract

Objective Common variants in PDE8B are associated with TSH, but apparently without any effect on thyroid hormone levels which is difficult to explain. Furthermore the stability of the association has not been examined in longitudinal studies or in patients on levothyroxine. Design Four cohorts were used (N=2,557) the Busselton Health Study (thyroid function measured on 2 occasions), DEPTH, EFSOCH (selective cohorts) and WATTS (individuals on levothyroxine). Methods Meta-analysis to clarify associations between the rs4704397 SNP in PDE8B on TSH, T3 and T4 levels. Results Meta-analysis confirmed that genetic variation in PDE8B was associated with TSH (p=1.64x10-10 0.20 SD/allele, 95%CI 0.142, 0.267) and identified a possible new association with free T4 (p=0.023, -0.07 SD/allele, 95% CI -0.137, -0.01) no association was seen with free T3 (p=0.218). The association between PDE8B and

TSH was similar in 1981 (0.14 SD/allele, 95%CI 0.04, 0.238) and 1994 (0.20 SD/allele, 95%CI 0.102, 0.300) and even more consistent between PDE8B and free T4 in 1981 (-0.068 SD/allele, 95% CI: -0.167, 0.031) and 1994 (-0.07 SD/allele, 95%CI: -0.170, 0.030). No associations were seen between PDE8B and thyroid hormone parameters in individuals on levothyroxine. Conclusion Common genetic variation in PDE8B is associated with reciprocal changes in TSH and free T4 levels that are consistent over time and lost in individuals on levothyroxine. These findings identify a possible genetic marker reflecting variation in thyroid hormone output that will be of value in epidemiological studies and provides additional evidence that PDE8B is involved in TSH signaling in the thyroid.