Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 My Hubby was Dx with CML 10-2003; on Gleevec from 10-2003 to 11-2004 meds with too many side effects; took off Gleevec11-2004. (Gleevec 400 mg to 800mg.) He was put on Sprycel 70mg. 7-2006 for 6 wks. took off because his counts went down too low and too fast. Now he will go on lower dose 20mg.of Sprycel as soon as its available. (All cancer meds quit working for him; he is now without any cancer meds until we recieve the lower dosage of Sprycel; this all has happened since 7-2006) This has been a roller coaster ride; what worked for one person didn't work for him; Now we are trying to fight off all the infections.. He isn't a canidate for BMT; no more BM Asp. I wish you all the very best!!!! kristi122677 <kristi122677@...> wrote: As most of you know...I am on here for my best friend Stacey. The site is fantastic. HEre's where we are.... Doctor's appt yestruday....BOne biopsy 2 weeks prior. I hope I am saying all of this correctly. Doctor is stating 91% good cells. 9% bad. The 9% is of GREAT concern. She should be in remission already from the Gleevac and she's not. Double the dose of Gleevac from 400mg to 800mg....apparently the side effects are greater per the dose. In three months they will go back, do another bone bioposy and if NOTHING has changed....and if she is not in BLAST phase by then....either a bone marrow transplant or possibly a new drug. Does any of this sound or make sense to anyone. I guess we were just hoping for some better news. --------------------------------- Everyone is raving about the all-new beta. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 % are no good you need a count of wc 4.0 to 10.5 rc4.10 to5.60 mine was 154,000 wc on 12/05 10 days on 800 gleevec off 7 have been on 400 since a fish test [cytogenetics report} was 0 on 10 3 06 average is 6 to 18 months Bone marrow is no walk in the park,a lot can go wrong,was this explained ! [ ] CML Questions As most of you know...I am on here for my best friend Stacey. The site is fantastic. HEre's where we are.... Doctor's appt yestruday... .BOne biopsy 2 weeks prior. I hope I am saying all of this correctly. Doctor is stating 91% good cells. 9% bad. The 9% is of GREAT concern. She should be in remission already from the Gleevac and she's not. Double the dose of Gleevac from 400mg to 800mg....apparently the side effects are greater per the dose. In three months they will go back, do another bone bioposy and if NOTHING has changed....and if she is not in BLAST phase by then....either a bone marrow transplant or possibly a new drug. Does any of this sound or make sense to anyone. I guess we were just hoping for some better news. ________________________________________________________________________________\ ____ Cheap talk? Check out Messenger's low PC-to-Phone call rates. http://voice. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 sorry to here of problems , you will see on post it,s a crap shoot for remission good luck paul tn. Re: [ ] CML Questions My Hubby was Dx with CML 10-2003; on Gleevec from 10-2003 to 11-2004 meds with too many side effects; took off Gleevec11-2004. (Gleevec 400 mg to 800mg.) He was put on Sprycel 70mg. 7-2006 for 6 wks. took off because his counts went down too low and too fast. Now he will go on lower dose 20mg.of Sprycel as soon as its available. (All cancer meds quit working for him; he is now without any cancer meds until we recieve the lower dosage of Sprycel; this all has happened since 7-2006) This has been a roller coaster ride; what worked for one person didn't work for him; Now we are trying to fight off all the infections.. He isn't a canidate for BMT; no more BM Asp. I wish you all the very best!!!! kristi122677 <kristi122677> wrote: As most of you know...I am on here for my best friend Stacey. The site is fantastic. HEre's where we are.... Doctor's appt yestruday... .BOne biopsy 2 weeks prior. I hope I am saying all of this correctly. Doctor is stating 91% good cells. 9% bad. The 9% is of GREAT concern. She should be in remission already from the Gleevac and she's not. Double the dose of Gleevac from 400mg to 800mg....apparently the side effects are greater per the dose. In three months they will go back, do another bone bioposy and if NOTHING has changed....and if she is not in BLAST phase by then....either a bone marrow transplant or possibly a new drug. Does any of this sound or make sense to anyone. I guess we were just hoping for some better news. ------------ --------- --------- --- Everyone is raving about the all-new beta. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 My wife has been on 20 mg twice a day for just about a year now and she deals with low WBC and low ANC all the time with Neupogen shots...yet she has been able to achieve and maintain pcru. Good luck! _____ From: Trafford [mailto:free62ann@...] Sent: Tuesday, November 28, 2006 10:32 AM Subject: Re: [ ] CML Questions My Hubby was Dx with CML 10-2003; on Gleevec from 10-2003 to 11-2004 meds with too many side effects; took off Gleevec11-2004. (Gleevec 400 mg to 800mg.) He was put on Sprycel 70mg. 7-2006 for 6 wks. took off because his counts went down too low and too fast. Now he will go on lower dose 20mg.of Sprycel as soon as its available. (All cancer meds quit working for him; he is now without any cancer meds until we recieve the lower dosage of Sprycel; this all has happened since 7-2006) This has been a roller coaster ride; what worked for one person didn't work for him; Now we are trying to fight off all the infections.. He isn't a canidate for BMT; no more BM Asp. I wish you all the very best!!!! kristi122677 <kristi122677@ <mailto:kristi122677%40> > wrote: As most of you know...I am on here for my best friend Stacey. The site is fantastic. HEre's where we are.... Doctor's appt yestruday....BOne biopsy 2 weeks prior. I hope I am saying all of this correctly. Doctor is stating 91% good cells. 9% bad. The 9% is of GREAT concern. She should be in remission already from the Gleevac and she's not. Double the dose of Gleevac from 400mg to 800mg....apparently the side effects are greater per the dose. In three months they will go back, do another bone bioposy and if NOTHING has changed....and if she is not in BLAST phase by then....either a bone marrow transplant or possibly a new drug. Does any of this sound or make sense to anyone. I guess we were just hoping for some better news. --------------------------------- Everyone is raving about the all-new beta. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 28, 2006 Report Share Posted November 28, 2006 When was she Diagnosed? It took over a year for me to get to remission on Gleevec. The 800 mg is correct. If the 9.0 doesnot go below 1.0 within a year her chance of staying in a good remission is lessened. Sometimes good things take a little time. Good luck Therese kristi122677 <kristi122677@...> wrote: As most of you know...I am on here for my best friend Stacey. The site is fantastic. HEre's where we are.... Doctor's appt yestruday....BOne biopsy 2 weeks prior. I hope I am saying all of this correctly. Doctor is stating 91% good cells. 9% bad. The 9% is of GREAT concern. She should be in remission already from the Gleevac and she's not. Double the dose of Gleevac from 400mg to 800mg....apparently the side effects are greater per the dose. In three months they will go back, do another bone bioposy and if NOTHING has changed....and if she is not in BLAST phase by then....either a bone marrow transplant or possibly a new drug. Does any of this sound or make sense to anyone. I guess we were just hoping for some better news. --------------------------------- Everyone is raving about the all-new beta. Quote Link to comment Share on other sites More sharing options...
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