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CML in children - Jamal

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Hi All, after a long absence,

is probably right that Gleevec (IM) would be the best drug if this is

Ph+ CML, but CML in a child this young is often quite a different disease

than in older people and management choices may be more different than I

know. The risks and benefits of transplant are also very different - and

highly favorable for children vs. adults: they usually tolerate the

procedure better and the mortality is much lower (50% mortality is much

higher than most centers experience on average, though many factors play

into the risk).

My best to everyone,

R

> I don't know a lot Jamal but I would be very concerned with your daughter's

> care. Your daughter should be on gleevec or a similar medication and at her

> age I don't know that a BMT would be a great idea. It is a scary process for

> a adult with about a 50% survival rate from what I understand. Gleevec is a

> medication that people with CML take once daily which keeps our WBC low and

> keeps the leukemia for most from returning. There are side effects for many

> people but it keeps you alive. It is a drug that you are on forever but it

> circumvents a BMT. Please seek a second opinion if you can.

> Hang in there, best of luck!!!

> :{

>

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