RE: BMS-354825 Trial (Dasatinib)

[Guest guest]

Hi Ursula,

Sorry to hear that you ran into these problems so early in the game.

Were you randomized to the 140 mg dose in one shot? This could be the

cause. Many patients have had their doses reduced because of side

effects and have done much better.

Zavie

Zavie (age 67)

67 Shoreham Avenue

Ottawa, Canada, dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

PCRU 5/02 at RVH

2.8 log reduction Sep/05

3.0 log reduction Jan 06

e-mail: zmiller@...

Tel: 613-726-1117

Fax: 309-296-0807

Cell: 613-202-0204

ID: zaviem

[ ] BMS-354825 Trial (Dasatinib)

Hello to all of you,

As some of you are probably aware I am participating in the BMS Trial

and are now in my second week.

I just like to give you some insight into the side effects I am

experiencing since the last week.

Besides the obvious Nausea, Headaches and swelling of facial parts and

the feeling of having a Brick on top of my eyes I also have severe

pain underneath my right ribcase which extented allover my pelvic and

my lower Back including my legs, in particular the right leg.

I went to the Emergency Dept of a known cancer hospital and had a

bloodtest done which did not confirm my fear of acute appendicitis.

An ultrasound of my ovaries did not show any abnormal signs either.

I am still having this pain in my right side underneath the ribcage

and am not fully convinced that it is a side effect of the Drug, but

perhaps an inflammation of the appendix.

Besides all that I am not my usual self but feel weak and lustless.

I do hope that in a few days I do overcome all those " side effects "

and have my life back as it used to be.

If it were not for this " fake " appendix symptoms I could deal with all

the other signs.

I'll be seeing my Doc at the MacCallum Cancer Hospital in

Melbourne by next Tuesday for a big check up.

Folks that's it for today.

I wish you all well and happy!

Ursula