Re: Gleevec inhibits c-fms

[Guest guest]

At 06:02 PM 4/25/06 +0000, you wrote:

> Although this finding has important implications

>with regard to potential side effects in patients currently

>receiving imatinib therapy, these results suggest that imatinib may

>also be useful in the treatment of diseases where c-fms is

>implicated.

Hi Tracey,

I wonder what the important implications regarding potential side effects

from inhibiting c-fms are? if you have a chance, can you see what this

enzyme is important for. I am sure that there are other things that IM is

inhibiting that are unknown at this time....and might explain some of the

other side effects that some folks have.

Thanks for sharing your research.

C.

[Guest guest]

Hi ,

I agree that Gleevec probably inhibits more things than we realize

and could explain many of our side effects. I think once

explained how the inhibition of c-kit was probably responsible for

the diarreah that so many of us have.

I've been looking into this c-fms and found a detailed abstract that

explains how it can play a role in breast development, lactation and

breast cancer.

" Colony stimulating factor (CSF-1) and its receptor (CSF-1R, product

of c-fms proto-oncogene) were initially implicated as essential for

normal monocyte development as well as for trophoblastic

implantation. However, studies have demonstrated that CSF-1 and CSF-

1R have additional roles in mammary gland development during

pregnancy and lactation. This apparent role for CSF-1/CSF-1R in

normal mammary gland development is very intriguing because this

receptor/ligand pair has also been found to be important in the

biology of breast cancer in which abnormal expression of CSF-1 and

its receptor correlates with tumor cell invasiveness and adverse

clinical prognosis. Recent findings also implicate tumor-produced

CSF-1 in promotion of bone metastasis in breast cancer, and a

certain membrane-associated form of CSF-1 appears to induce immunity

against tumors. This review aims to summarize recent findings on the

role of CSF-1 and its receptor in normal and neoplastic mammary

development that may elucidate potential relationships of growth

factor–induced biological changes in the breast during pregnancy and

tumor progression. "

You can see the rest of the abstract here:

http://www.ebmonline.org/cgi/content/full/229/1/1

I'll see what else I can dig up.

Take care,

Tracey

> Hi Tracey,

>

> I wonder what the important implications regarding potential side

effects

> from inhibiting c-fms are? if you have a chance, can you see what

this

> enzyme is important for. I am sure that there are other things

that IM is

> inhibiting that are unknown at this time....and might explain some

of the

> other side effects that some folks have.

>

> Thanks for sharing your research.

> C.

>