Re: Drug resistance

[Guest guest]

In a message dated 8/26/00 2:06:07 PM Pacific Daylight Time,

egroups writes:

<< Did anyone get told that DS kids develop a resistance to anesthesia? >>

Loriann:

Not anesthesia exactly, but resistance to ANY drugs, such as the ones we use

now for behaviors, i.e., Risperdal, Ritalin, etc.

And high tolerance for pain too.......

[Guest guest]

>

> I have a fundamental question about drug resistance that has been

> bothering me since I began taking antifungal medication six months

> ago. At one point, my fungus was found to be resistant to most of

> the " -azole " brands, so they were replaced by other drugs. Now I am

> worried if that was wise. If the fungus has become strong enough to

> overpower the effect of the azole drugs, will it not be even more

> powerful and dangerous if the azole drug is removed? I mean, doesn't

the presence of the azole drug keep the damned fungus occupied, so that

it has less power to develop resistance to the new drug that is being

launched against it? Could perhaps a series of drugs to which the

candida is resistant have an effect on it if they are taken

simultaneously?

==>Drugs are the problem. Candida does not become resistant to natural

antifungals, i.e. garlic, coconut oil, oil of oregano, etc. But the

resistance theory does sell more drugs.

Besides, the diet and supplements are the most important aspect of

getting rid of candida, not drugs like the azoles, which are extremely

hard on the liver. There are no quick fixes when curing candida. We

leave 'quick fixes' up to the doctors to apply, which depresses our

immune system even more. The diet and supplements build up the immune

system, which at some point will keep the candida in check all by

itself.

Bee

[Guest guest]

At 04:52 PM 6/5/06 +0000, you wrote:

>Been reading a lot of stuff about people developing a resistance to

>Gleevec. Can somebosy, in simple terms please explain what

>circumstances would constitute resistance to Gleevec?

Hi Jane,

Resistance to Gleevec is when the drug is not working for you. There are 2

basic forms of this: 1. Primary resistance is when you never get a full

cytogenetic response to the drug....some people stay 100% ph+ while taking

Gleevec (but it can control their blood counts and seems to prevent disease

progression, sometimes they are just stable)........less than a complete

response to Gleevec, reaching CCR (the big ZERO) is considered to be a

suboptimal response.

2. The second type of resistance is developed while using the

drug......mutations can develop which prevent the drug from binding and

they drug becomes less effective or no longer works. There are maybe 2

dozen or more know mutations at the binding site.

With either of these situations, you might increase the dose of

Gleevec....or switch to one of the new drugs (BMS or AMN).

Resistance is not intolerance of the drug..........which is another reason

someone might have qualified for one of the new drugs. This can be

intolerable side effects or maybe a liver toxicity from the drug.

Hope this helps.

Bottom line now is that when a person does develop resistance (except for

one bad mutation) there are now 2 new drugs (in trial and soon to be

approved).

C.

[Guest guest]

Thanks - that was helpful. What kind of figures (i.e. from

blood tests) would constitute reistance?

>

> >Been reading a lot of stuff about people developing a resistance

to

> >Gleevec. Can somebosy, in simple terms please explain what

> >circumstances would constitute resistance to Gleevec?

>

> Hi Jane,

>

> Resistance to Gleevec is when the drug is not working for you.

There are 2

> basic forms of this: 1. Primary resistance is when you never get a

full

> cytogenetic response to the drug....some people stay 100% ph+

while taking

> Gleevec (but it can control their blood counts and seems to

prevent disease

> progression, sometimes they are just stable)........less than a

complete

> response to Gleevec, reaching CCR (the big ZERO) is considered to

be a

> suboptimal response.

>

> 2. The second type of resistance is developed while using the

> drug......mutations can develop which prevent the drug from

binding and

> they drug becomes less effective or no longer works. There are

maybe 2

> dozen or more know mutations at the binding site.

>

> With either of these situations, you might increase the dose of

> Gleevec....or switch to one of the new drugs (BMS or AMN).

>

> Resistance is not intolerance of the drug..........which is

another reason

> someone might have qualified for one of the new drugs. This can be

> intolerable side effects or maybe a liver toxicity from the drug.

>

> Hope this helps.

> Bottom line now is that when a person does develop resistance

(except for

> one bad mutation) there are now 2 new drugs (in trial and soon to

be

> approved).

>

> C.

>

[Guest guest]

At 10:25 AM 6/6/06 +0000, you wrote:

>Thanks - that was helpful. What kind of figures (i.e. from

>blood tests) would constitute reistance?

Resistance would first be seen in increasing pcr values (because that is

the most sensitive test....so a steady trend upward, at least by one

log)........or increasing ph+ (cytogenetics) from a bma. You will not

detect this early from a blood test (other than a pcr). So if someone is 0%

ph+.......then 3 months later 25%, then the next test 60%.........clearly

indication that Gleevec is no longer working and that a mutation most

likely has developed that is resistance to Gleevec). This is why regular

monitoring of CML is needed.....it is not OK to just say that my blood

counts (whites, reds, platelets) are normal.

C.