Guest guest Posted April 4, 2006 Report Share Posted April 4, 2006 1: J Drugs Dermatol. 2006 Mar;5(3):228-31. Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. Scheinfeld N. Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA. Scheinfeld@... Cutaneous reactions to imatinib are common and occur in 9.5% to 69% of patients depending on the series reported. Maculopapular eruptions, erythematous eruptions, edema, and periorbital edema are the most common adverse events observed. Imatinib can also induce severe skin eruptions and generalized skin eruptions. Toxic epidermal necrolysis and s syndrome has been linked to the use of imatinib. Imatinib has caused acute generalized exanthematous pustulosis. Purpuric vasculitis and mycosis fungoides-like reactions has occurred after imatinib use. Rarer side effects include: hypopigmentation, lichenoid reactions, pityriasiform eruptions, pityriasis rosea, psoriasis, reactivation or induction of porphyria cutanea tarda, neutrophilic eccrine hidradenitis, Sweet's syndrome, erythema nodosum, EBV-positive cutaneous B-cell lymphoproliferative disease, possible induction of squamous cell, hyaline cell syringomas, follicular mucinosis, pseudolymphoma-type drug eruptions and malpighian epitheliomas. Most cutaneous eruptions caused by imatinib do not necessitate discontinuance of imatinib and are usually self limited, despite continued treatment. Administration of oral or topical corticosteroids can ameliorate some of imatinib's cutaneous side effects. PMID: 16573254 [PubMed - in process] Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 5, 2006 Report Share Posted April 5, 2006 In a message dated 4/4/2006 3:29:24 P.M. Eastern Daylight Time, zmiller@... writes: psoriasis, reactivation or induction of porphyria cutanea tarda, neutrophilic eccrine hidradenitis, Sweet's syndrome, erythema nodosum, EBV-positive cutaneous B-cell lymphoproliferative disease, possible induction of squamous cell, hyaline cell syringomas, follicular mucinosis, pseudolymphoma-type drug eruptions and malpighian epitheliomas. Most cutaneous eruptions caused by imatinib do not necessitate discontinuance of imatinib and are usually self limited, despite continued treatment. Administration of oral or topical corticosteroids Dear Zavie, well, I do not understand much of the medicalese but I do know that I have suffered on/off from strange skin lesions for about two years now, but only in the hot weather. I wondered where they came from, and I was treated for what the doctor called impetigo, but I am beginning to wonder if it was not Gleevec-related after all. Never in my life have I had a rash, nor skin lesions except for chicken pox as a child, so I was quite stymied by the bouts of eruptions the last two years. At first the lesions were localized to my hands, but spread to my face as well. I am on something called Mupirocin ointment 22grams daily as preventive medicine. I will print this out so I can add it to my now-growing list of side-effects. Thanks for sharing this, Lynne A. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 12, 2006 Report Share Posted April 12, 2006 I find that Gleevec has multiple side effects if not taken correctly: Plenty, I mean Plenty of fluids (water) and for me, on a full stomach (ieliminates the nausea). Also, I read that while on Gleevec, one should stay out of the sun. I wear loose clothing and hats, lots of hats whild continuing to remain hydrated. I still tan but no side effects from Gleevec, good luck...So, Yrulooknback.... MoonQn1@... wrote: In a message dated 4/4/2006 3:29:24 P.M. Eastern Daylight Time, zmiller@... writes: psoriasis, reactivation or induction of porphyria cutanea tarda, neutrophilic eccrine hidradenitis, Sweet's syndrome, erythema nodosum, EBV-positive cutaneous B-cell lymphoproliferative disease, possible induction of squamous cell, hyaline cell syringomas, follicular mucinosis, pseudolymphoma-type drug eruptions and malpighian epitheliomas. Most cutaneous eruptions caused by imatinib do not necessitate discontinuance of imatinib and are usually self limited, despite continued treatment. Administration of oral or topical corticosteroids Dear Zavie, well, I do not understand much of the medicalese but I do know that I have suffered on/off from strange skin lesions for about two years now, but only in the hot weather. I wondered where they came from, and I was treated for what the doctor called impetigo, but I am beginning to wonder if it was not Gleevec-related after all. Never in my life have I had a rash, nor skin lesions except for chicken pox as a child, so I was quite stymied by the bouts of eruptions the last two years. At first the lesions were localized to my hands, but spread to my face as well. I am on something called Mupirocin ointment 22grams daily as preventive medicine. I will print this out so I can add it to my now-growing list of side-effects. Thanks for sharing this, Lynne A. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2007 Report Share Posted January 23, 2007 Hi we all have different side effects,myself at 176 lp and on 400 ,I have wet eyes and bowl problems.Your weight I would wonder about 400 but that is the recomened dose. dxt dec23 06 count 154,000 TN. [ ] Gleevec side effects Hello Everyone, My name is ' , I am 38 years old and I was diagnosed with CML in December 2006. I am new to all of this and I have so many questions. I was accepted at MDACC and my dr. put me on Gleevec 400mg. I am having a few side effects from the drug. My eyes stay extremely swollen all day long. I also CANNOT eat. I weight 95lbs and I have to make myself eat. I was wondering if anyone else is experiencing these side effects and if they go away over time? Any responses would be appreciated. ' ------------ --------- --------- --- Never miss an email again! Toolbar alerts you the instant new Mail arrives. Check it out. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2007 Report Share Posted January 23, 2007 Hi , The side effects can be pretty rough the first while. For most, they subside tot he point where they are quite managable. My husband has been on gleevec since the end of oct. 2006 and experienced very bad side effects (swelling, vomitting, naseau, bone pains, insomnia) But the side effects are much better now ( 12 weeks after starting gleevec) Have you tried anti-naseau medication??- this has helped him get back his appetite. The 400mgs is the recommended beginning dose- each person metabolizes it differently. As far as the eye swelling- this one is common and difficult. Watch out for your ankles as well. The only thing we have done to deal with the swelling is to have a reduced salt diet (salt causes more water retention) And lower the amounts of breads (also water retention) Drinking alot of water throughout the day helps as it flushes the system...oh and make sure when you are home you have your feet up ...(if ankle swelling is an issue) HTH shalyn Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2007 Report Share Posted January 23, 2007 Thank you very much for the advice. I will get with my dr. about the nausea medication. He actually told me that I would gain weight on it. Maybe that takes a while. Good Luck and Take Care. ' shalyn@... wrote: Hi , The side effects can be pretty rough the first while. For most, they subside tot he point where they are quite managable. My husband has been on gleevec since the end of oct. 2006 and experienced very bad side effects (swelling, vomitting, naseau, bone pains, insomnia) But the side effects are much better now ( 12 weeks after starting gleevec) Have you tried anti-naseau medication??- this has helped him get back his appetite. The 400mgs is the recommended beginning dose- each person metabolizes it differently. As far as the eye swelling- this one is common and difficult. Watch out for your ankles as well. The only thing we have done to deal with the swelling is to have a reduced salt diet (salt causes more water retention) And lower the amounts of breads (also water retention) Drinking alot of water throughout the day helps as it flushes the system...oh and make sure when you are home you have your feet up ...(if ankle swelling is an issue) HTH shalyn --------------------------------- TV dinner still cooling? Check out " Tonight's Picks " on TV. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2007 Report Share Posted January 23, 2007 Hello ....I was having bowel problems at first because I was not eating with the Gleevec. Now I make sure that I force something pretty healthy down at dinner time and it doesn't affect me near a badly. ' Shipley <paulorkay@...> wrote: Hi we all have different side effects,myself at 176 lp and on 400 ,I have wet eyes and bowl problems.Your weight I would wonder about 400 but that is the recomened dose. dxt dec23 06 count 154,000 TN. [ ] Gleevec side effects Hello Everyone, My name is ' , I am 38 years old and I was diagnosed with CML in December 2006. I am new to all of this and I have so many questions. I was accepted at MDACC and my dr. put me on Gleevec 400mg. I am having a few side effects from the drug. My eyes stay extremely swollen all day long. I also CANNOT eat. I weight 95lbs and I have to make myself eat. I was wondering if anyone else is experiencing these side effects and if they go away over time? Any responses would be appreciated. ' ------------ --------- --------- --- Never miss an email again! Toolbar alerts you the instant new Mail arrives. Check it out. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 23, 2007 Report Share Posted January 23, 2007 Hi , If you do gain weight - it would likely be just water retention. My husband has actually lost weight but did recently seem to retain water more which caused his weight to be maintained. Some do gain weight because keeping the stomach 1/2 full seems to help with naseau...really it is so dependant on how YOU react to the gleevec. I think your side effects should subside soon- it took about 7 weeks for him....and yes please ask your physician about managing the side effects as some can be managed so you do not have to suffer. shalyn Quote Link to comment Share on other sites More sharing options...
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