Re: Free Kappa / Free Lambda ratio?

[Guest guest]

Would love to have comments on this as I have been researching the same issue.

- In , " lynnb65 " wrote:

>

> I've done some searching of this site and a few others, as well as some

googling, to interpret my latest labs from NIH, which have covered some ground

never measured for me before. I have a high value for Free Kappa Light Chain

(2.42) and a low value for Free Lambda Light Chains (.30). This yields a high

Free Kappa/Free Lambda ratio of 8.07. (Top of the NIH range is 1.78). I did

find one article which said this ratio could be one of the new prognostic

indicators .. and of course, being high was not good. (That seems to be where

my googling is getting me these days .. earlier I found my nice del 13q14 was

really a type 2 because I was 85% and thus NOT so nice.) Anyway, the abstract

of the article didn't really give an idea of how high the ratio had to be to be

" bad " . It also spoke of an out of range ratio having a correlation with CD 38+

and ZAP70+, which I am not. (I don't know my mutational status yet, but

hopefully will hear from NIH on that eventually or will have it tested locally).

>

> So of course we are in the wonderful but not applicable world of statistics,

where any of us can be the guy at the happy end of the curve. Would love to

hear more comments from others on this Kappa vs Lambda, the ratio, significance

of one or the other. I see from my net searches that these ratios are very

relevant for multiple myeloma .. is it early days for interpreting them in CLL

or have I missed the articles that I should have read?

>

> I'm thinking I will put away the rest of my NIH labs for a few days and

perhaps watch some HGTV International House Hunters or some other mindless but

fun stuff. In the mean time .. look forward to any and all comments.

>

> Just went back looking for the original article and instead found one from UK

researchers, 2009, " Abnormal serum free light chain ratios are associated with

poor survival and may reflect biological subgroups in patients with chronic

lymphocytic leukaemia. " I'm wondering if there is an implication from this

article that high Kappa / Lambda ratio implied unmutated IgVH? (That my be

stretching logic a bit.)

>

> Just found the first article I stumbled on .. and it refers to the above

article. Here is the link

http://www.cli-online.com/featured-articles/serum-free-light-chains-in-chronic-l\

ymphocytic-leukemia-light-at-the-end-of-the-tunnel/index.html I that link

doesn't work, you can google the title, " Serum free light chains in chronic

lymphocytic leukemia: light at the end of the tunnel? "

>

> Never a dull moment in the wonderful world of CLL.

>

> Lynn