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Tyrosine kinase inhibitor imatinib mesylate & chlorambucil

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According to the authors, this represents the first clinical trial examining the

potential synergy between a tyrosine kinase inhibitor and a conventional

alkylating agent for the treatment of CLL.

This is a tiny Phase I trial for previously treated CLL patients

The combination of chlorambucil and imatinib in patients with previously treated

CLL was well tolerated and showed evidence of clinical efficacy.

Cancer Chemother Pharmacol. 2010 Dec 1

Link: to Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21120481?dopt=Abstract

~chris

CLL CANADA

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