Guest guest Posted August 22, 2010 Report Share Posted August 22, 2010 Trisomy 12 cases frequently have atypical morphology and tend to have brighter CD20 and surface immunoglobulin. 'Discordant' just means that CD38 and ZAP-70 give results in different directions. In our large series such patients had a median prognosis of 15 years, but that was before the advent of FCR. Terry Hamblin MD In a message dated 23/08/2010 02:12:30 GMT Daylight Time, randolrn@... writes: Thanks for the article. I was tested for Zap 70 at a major Center and found to be neg but positive for CD38 in 36% (actually CD19/CD38, meaning the cells were co-expressing). This is at the beginning of my dx. back in 11/05. I remain at stage 0 with no symptoms at this time, which I am very grateful for. My docs said this is a discordent result, which I translate to mean it is hard to interpret. I think there are some cases like mine that are difficult to figure out. I am trisomy 12 and 13q del. My official dx. is atypical CLL. Chris Adks NY Quote Link to comment Share on other sites More sharing options...
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