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Major randomized trial, Cladribine vs Fludarabine combined with Cyclophosphimide

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Research just published in the Journal of Clinical Oncology reports on a large

randomized clinical trial of 423 patients in the Polish Adult Leukemia Group,

PALG-CLL3 Study.

Conclusion: 'Cladribine and fludarabine in combination with cyclophosphamide are

equally effective and safe first-line regimens for progressive CLL. Both

combinations have unsatisfactory activity in patients with 17p13 (TP53 gene)

deletion.'

Abstract

http://jco.ascopubs.org/cgi/content/abstract/JCO.2009.25.9630v1

~chris

http://cllcanada.ca

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