- AT-101 at UCSD San Diego

[Guest guest]

Thank you for the reply. I also have the added challenge of having

had Hep C (but was treated in 1999 succesully with

interferon/ribivirin) I was told that any treatment could reactivate

the Hep C. I'm trying to decipher which one would be less toxic to

me in that regard. One of my biggest fears is the Hep being

reactivated. I'm not sure this fear is in proper perspective

regarding all that can go right or go wrong with the various

treatments. I's hard to separate this fear and look at the situation

objectivly.

>

> Dear Garden Bird and and Everyone:

>

> This information below is from at CLL Research. He reported

this on his website yesterday. I think you will find it

interesting. I was wondering why no one was putting Rituxan

together with AT-101, it only made sense it seemed as AT-101 reduces

spleen and nodes. Then posted this below:

>

>

> s Report:

>

> Gossypol (aka AT-101) is a derivative of cottonseeds

> oil. It may act as a insecticide that works by

> slowing down the reproductive rate of insects that

> munch on it.

>

> Gossypol was tested in China as a male contraceptive,

> based on anecdotal reports that families who used

> cottonseed oil had smaller families. Testing began in

> the 1920s and continued into the 1980s.

>

> The main side effects reported were low potassium

> levels and permanent sterility, both occuring in a

> percentage of patients.

>

> In CLL, there have been reports of altered levels of

> some liver enzymes, which may indicate liver changes.

>

> There is one report in PubMed on the latter (note the

> doses given here are perhaps 5 times the dose given in

> the CLL study):

>

> Toxicol Lett. 1984 Dec;23(3):299-306.

>

> Effect of gossypol on liver metabolic enzymes in male

> rats.

>

> Ali SF, El-Sewedy SM.

>

> The effects of gossypol on liver metabolism were

> examined in male rats. Gossypol acetic acid was

> administered to Sprague-Dawley rats intraperitoneally

> (i.p.) at 5 mg/kg daily, 5 days/week for 2 weeks. The

> rats were killed 24 h after the last injection. The

> liver/body weight ratio (-42%), concentration of liver

> glutathione (-34%), activities of liver

> alpha-naphthtylacetate esterase (-30%) and DNase

> (-39%) were significantly decreased when compared to

> controls. Hepatic beta-glucuronidase (+37%), RNase

> (+35%) and serum alkaline RNase (+23%) activities were

> significantly increased. No changes were found in

> serum transaminases (SGPT, SGOT) or in hepatic RNA and

> DNA concentration.

>

> Elevation of liver and serum RNase activities suggest

> that gossypol treatment produces some catabolic

> effects. The depletion of hepatic glutathione and the

> elevation of beta-glucuronidase activity indicate that

> gossypol is hepatotoxic when given at this dose for 2

> weeks.

>

> PMID: 6084346 [PubMed - indexed for MEDLINE

>

> The gossypol as a single agent is still in clinical

> trials at UCSD and elsewhere.

>

> The trial combining AT-101 with rituximab is listed as

> 'recruiting patients' at UCSD.

> FURTHER INFO ON GOSSYPOL AT-101-A

> Here's an interesting one-page blurb on AT-101 with and without

> rituximab.

>

> http://www.ascentatherapeutics.com/pages/Poster%20JAMES%20AT-101%

20ASH%

> 202005.pdf

>

> It looks quite interesting. One of the challenges in CLL is

treating

> bulky nodes. AT-101 may be a good addition to the armamentarium

of

> the CLL doc. So far, trial results seem to show a low toxicity

> profile and decent-to-good results.

> SCOTT.

>

> I hope this helps Garden Bird and anyone interested.

> Kurt

>

>

>

>

> -------------- Original message --------------

> From: " garden_jbird " <go95mph@...>

> Hi I'm new to the group. I am currently a patient of Dr. Castro

at

> UCSD. It's time for me to try another treatment. Dr. Castro

> recommended the Rituxan and At 101 study.

> I am interested in anyones experience with this study or

experience at

> UCSD with Dr Castr. I have read some posts with patients of Dr.

> Kipps.

>

> thank you.

>

>