Guest guest Posted April 16, 2004 Report Share Posted April 16, 2004 Joe, please let us know about the blood work. It will be very interested in knowing the results. Good luck to you and have a nice weekend.! Re: Green Tea - Sue Hi all- I haven't posted in a while, but I thought I would share my experience. Diagnosed 9/03, FISH was not great (some bad and some good), ZAP-70 >20, WBC bloods climbing, nodes enlarging, etc. I've emailed some of you off-line and Dr. Gribben and I were assuming a late 04 treatment. Six months of RFC. I read the article from the Mayo clinic several weeks back and decided to give it a shot( green tea that is). I started taking 4 pills of GT extract per day about 6 days ago. In 6 days, my nodes are gone on my neck (right side), reduced on the left. I'm not feeling any discomfort in the spleen region and I feel great. I have NOT had any blood work since then, so I'm looking forward to seeing my counts on 6/1, but I can't believe how much better I feel. I know, sound's crazy, placebo effect, etc. But, I'm very excited about the results so far. > I don't have any info on t-cell and green tea. Anyone? > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2004 Report Share Posted April 17, 2004 Sue - super fantastic - I just went out and bought some - think we're on to something here - what's the dosage? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2004 Report Share Posted April 18, 2004 I don't know the dosage but I will bathe in the stuff it will keep me from having to repeat what I've been through. Has anyone checked to see if dosage is mentioned anywhere? It sure would be nice to know how much the people in the study were given. I sent the article on to my Nurse Practitioner at Stanford and she was very interested also. Wouldn't it be wonderful if something as simple as Green Tea would " cure " CLL? At least slow the progression? I would drink it til I burst if it meant no chemo treatments. And taking it in concentrated tablet form, even better. Green Tea doesn't taste all that wonderful. It certainly isn't Cherry Coke anyway. As of my last bone marrow biopsy I am in Complete Response but I'm drinking it just for a little extra insurance. Can't hurt. June 9th is the 4 year anniversary of my BMT and I fully intend to stay in CR. Sue Bunte jb50192@... wrote: Sue - super fantastic - I just went out and bought some - think we're on to something here - what's the dosage? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 18, 2004 Report Share Posted April 18, 2004 I found the following on the Mayo website. Does anyone know what (3 ug/ml) or (3-25 ug/ml) means in English? Sue Bunte Yean K Lee, D Bone, Ann K Strege, Diane F Jelinek, and Neil E Kay* Department of Medicine/Division of Hematology, Mayo Clinic, Rochester, MN, USA Department of Immunology, Mayo Clinic, Rochester, MN, USA * Corresponding author; email: kay.neil@.... We recently reported that chronic lymphocytic leukemia (CLL) cells synthesize and release VEGF under normoxic and hypoxic conditions. CLL B cells also express VEGF membrane receptors (VEGF-R1 and VEGF-R2), suggesting that they use VEGF as a survival factor. To assess the mechanism of apoptosis resistance related to VEGF, we determined the impact of VEGF on CLL B cells, and we studied the impact of epigallocatechin (EGCG), a known receptor tyrosine kinase (RTK) inhibitor, on VEGF receptor status and viability of CLL B cells. VEGF165 significantly increased apoptotic resistance of CLL B cells and immunoblotting revealed that VEGF-R1 and VEGF-R2 are spontaneously phosphorylated on CLL B cells. EGCG significantly increased apoptosis/cell death in 8 of 10 CLL samples measured by annexin V/propidium iodide (PI) staining. The increase in annexin V/PI staining was accompanied by caspase 3 activation and PARP cleavage at low concentrations of EGCG (3 µg/ml). Moreover, EGCG suppressed the proteins Bcl-2, XIAP and Mcl-1 in CLL B cells. Finally, EGCG (3-25 µg/ml) suppressed VEGF-R1 and VEGF-R2 phosphorylation, albeit incompletely. Thus, these results suggest that VEGF signaling regulates survival signals in CLL cells and that interruption of this autocrine pathway results in caspase activation and subsequent leukemic cell death. Sue Bunte <zamar1@...> wrote:I don't know the dosage but I will bathe in the stuff it will keep me from having to repeat what I've been through. Has anyone checked to see if dosage is mentioned anywhere? It sure would be nice to know how much the people in the study were given. I sent the article on to my Nurse Practitioner at Stanford and she was very interested also. Wouldn't it be wonderful if something as simple as Green Tea would " cure " CLL? At least slow the progression? I would drink it til I burst if it meant no chemo treatments. And taking it in concentrated tablet form, even better. Green Tea doesn't taste all that wonderful. It certainly isn't Cherry Coke anyway. As of my last bone marrow biopsy I am in Complete Response but I'm drinking it just for a little extra insurance. Can't hurt. June 9th is the 4 year anniversary of my BMT and I fully intend to stay in CR. Sue Bunte jb50192@... wrote: Sue - super fantastic - I just went out and bought some - think we're on to something here - what's the dosage? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 19, 2004 Report Share Posted April 19, 2004 Micrograms per milliliter Quote Link to comment Share on other sites More sharing options...
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