WOW Re: Multiple evidence for an early age pro-oxidant state in DS patients.

[Guest guest]

Wow

I'm not sure if I really read this right because of the " big words "

ha, but highly oxygenated cells helps to fight the major

phenotypic features, such as early ageing. I really believe in this

Liquidity Juice called LiquiVida more now. Not only a very powerful

antioxident but I know that if we are breaking down the hydrogen

peroxide into water and OXYGEN! then we are producing highly

oxygnated cells. I am so stoked to see more research. But like I

said, Did I read these big words right?

Jess

>

> Has this already been posted?? I don't remember reading it before.

>

> KathyR

>

>

>

>

> Biogerontology. <javascript:AL_get(this,%20'jour',%

20'Biogerontology.');>

> 2006 Apr 13; [Epub ahead of print]

>

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> Multiple evidence for an early age pro-oxidant state in Down

Syndrome

> patients.

>

>

> <http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

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> bmed_Abstract & term=%22Pallardo+FV%22%5BAuthor%5D> Pallardo FV,

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> bmed_Abstract & term=%22d%27Ischia+M%22%5BAuthor%5D> d'Ischia M,

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> bmed_Abstract & term=%22+FJ%22%5BAuthor%5D> FJ,

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> bmed_Abstract & term=%22Zatterale+A%22%5BAuthor%5D> Zatterale A,

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> bmed_Abstract & term=%22Castello+G%22%5BAuthor%5D> Castello G,

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> Fernandez-Delgado R,

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> bmed_Abstract & term=%22Dunster+C%22%5BAuthor%5D> Dunster C,

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> bmed_Abstract & term=%22Lloret+A%22%5BAuthor%5D> Lloret A,

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> bmed_Abstract & term=%22Pisanti+MA%22%5BAuthor%5D> Pisanti MA,

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> bmed_Abstract & term=%22Vuttariello+E%22%5BAuthor%5D> Vuttariello E,

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> bmed_Abstract & term=%22Pagano+G%22%5BAuthor%5D> Pagano G.

>

> Department of Physiology, University of Valencia, E-46010,

Valencia, Spain.

>

> Oxidative stress has been associated with Down syndrome (DS) and

with its

> major phenotypic features, such as early ageing. In order to

evaluate an in

> vivo pro-oxidant state, the following analytes were measured in a

group of

> DS patients aged 2 months to 57 years: (a) leukocyte

> 8-hydroxy-2'-deoxyguanosine (8-OHdG); ( blood glutathione; ©

plasma

> levels of: glyoxal (Glx) and methylglyoxal (MGlx); some

antioxidants (uric

> acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase

(XO)

> activity. A significant 1.5-fold increase in 8-OHdG levels was

observed in

> 28 DS patients vs. 63 controls, with a sharper increase in DS

patients aged

> up to 30 years. The GSSG:GSHx100 ratio was significantly higher in

young DS

> patients (< 15 years), in contrast to DS patients aged >/=15 years

that

> showed a significant decrease in the GSSG:GSHx100 ratio ratio vs.

controls

> of the respective age groups. Plasma Glx levels were significantly

higher in

> young DS patients, whereas no significant difference was detected

in DS

> patients aged >/=15 years. Unlike Glx, the plasma levels of MGlx

were found

> to be significantly lower in DS patients vs. controls. A

significant

> increase was observed in plasma levels of UA in DS patients that

could be

> related to an increased plasma XO activity in DS patients. The

plasma

> concentrations of AA were also increased in young (< 15 years) DS

patients,

> but not in older patients vs. controls in the same age range. The

levels of

> Vitamin E in DS patients did not differ from the values determined

in

> control donors. The evidence for a multiple pro-oxidant state in

young DS

> patients supports the role of oxidative stress in DS phenotype,

with

> relevant distinctions according to patients' ages.

>

> PMID: 16612664 [PubMed - as supplied by publisher]

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