WOW Re: Multiple evidence for an early age pro-oxidant state in DS patients.

[Guest guest]

Basically it says that blood levels of certain things that show

oxidative stress were done on people w/Ds ages2 – 57 yrs.,,,that babies

and younger people w/Ds had higher pro-oxidant levels than the older ones (in

other words, the damage due to oxidation increases with age)..so my take on

that is that antioxidants would be useful to help prevent damage/early aging,

etc…

Here is a page with an explanation of oxidation, anti-oxidants, lipid

peroxidation:

http://www.chelationtherapyonline.com/articles/p39.htm

KathyR

From: Down Syndrome Treatment [mailto:Down Syndrome Treatment ] On Behalf Of

Sent: Thursday, June 29, 2006 2:28

AM

Down Syndrome Treatment

Subject:

WOW Re: Multiple evidence for an early age

pro-oxidant state in DS patients.

Wow

I'm not sure if I really read this right because of the " big words "

ha, but highly oxygenated cells helps to fight the major

phenotypic features, such as early ageing. I really believe in this

Liquidity Juice called LiquiVida more now. Not only a very powerful

antioxident but I know that if we are breaking down the hydrogen

peroxide into water and OXYGEN! then we are producing highly

oxygnated cells. I am so stoked to see more research. But like I

said, Did I read these big words right?

Jess

>

> Has this already been posted?? I don't remember reading it before.

>

> KathyR

>

> > Department of Physiology, University

of Valencia, E-46010,

Valencia, Spain.

>

> Oxidative stress has been associated with Down syndrome (DS) and

with its

> major phenotypic features, such as early ageing. In order to

evaluate an in

> vivo pro-oxidant state, the following analytes were measured in a

group of

> DS patients aged 2 months to 57 years: (a) leukocyte

> 8-hydroxy-2'-deoxyguanosine (8-OHdG); ( blood glutathione; ©

plasma

> levels of: glyoxal (Glx) and methylglyoxal (MGlx); some

antioxidants (uric

> acid, UA, ascorbic acid, AA and Vitamin E), and xanthine oxidase

(XO)

> activity. A significant 1.5-fold increase in 8-OHdG levels was

observed in

> 28 DS patients vs. 63 controls, with a sharper increase in DS

patients aged

> up to 30 years. The GSSG:GSHx100 ratio was significantly higher in

young DS

> patients (< 15 years), in contrast to DS patients aged >/=15 years

that

> showed a significant decrease in the GSSG:GSHx100 ratio ratio vs.

controls

> of the respective age groups. Plasma Glx levels were significantly

higher in

> young DS patients, whereas no significant difference was detected

in DS

> patients aged >/=15 years. Unlike Glx, the plasma levels of MGlx

were found

> to be significantly lower in DS patients vs. controls. A

significant

> increase was observed in plasma levels of UA in DS patients that

could be

> related to an increased plasma XO activity in DS patients. The

plasma

> concentrations of AA were also increased in young (< 15 years) DS

patients,

> but not in older patients vs. controls in the same age range. The

levels of

> Vitamin E in DS patients did not differ from the values determined

in

> control donors. The evidence for a multiple pro-oxidant state in

young DS

> patients supports the role of oxidative stress in DS phenotype,

with

> relevant distinctions according to patients' ages.

>

> PMID: 16612664 [PubMed - as supplied by publisher]

>

>

>

> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?

db=pubmed & cmd=Retrieve & dopt=Ab

> stract & list_uids=16612664 & query_hl=2 & itool=pubmed_docsum

[Guest guest]

Is LiquiVida what they were using in the study?