reply to asfy

[Guest guest]

Hello asfy,

Thank you for all your really constructive comments. It is just what I

need to try and assess if this track is viable or not. You know I have been so

hooked up on this particular paper for so long. There are several reasons:

1. It offers a cure rather than a treatment of the symptoms,

2. It all makes so much sense, what with sleep having so much to do with how I

feel and feeling so much worse in the morning. I also suffer from migraines

which are linked to low(?)seratonin/melatonin levels.

That was something I was going to mention actually. I tried putting a light on a

timer beside my bed. It was set to come on about 2hours before I got up. I then

drank 4 cups of coffee in about an hour and a half (as it can reduce your

melatonin levels). I ate very small meals at breakfast and lunch as food can

also cause a peak in melatonin levels. Guess what happened?...... migraine!

Can't win eh? Are our bodies too finely tuned?

Anyhow, back to the questions you asked. It spurred me on to go off and find the

answers to the ones I didn't know. Gosh this stuff is so complicated in these

papers isn't it?

* I too have only read the abstracts of most of her other papers.I

think mabe I have read one other full paper but can't find it at

the moment.

* I did find evidence that 5-sulphatoxyserotonin was a metabolite of

melatonin.Among others :(Djahanbakhch, Kadva, Street, Silman. The

pineal and

extra-pineal origins of 5-sulphatoxy N-acetyl-serotonin in humans.

J Pineal Res. 1999 May;26(4):221-6.) Although I have only read

the abstract. (on pubmed.gov)

* I also found evidence that N-acetyl serotonin has similar

chemical behaviour as aspirin. They both stimulate glutathione

peroxidase and affect lipid peroxidation (which is linked to

platelet aggregation). I got a bit lost in exactly which way they

affect lipid peroxidation. I thought I might have found

conflicting evidence but then got so confused in

whether 'catalyses the decomposition of lipid peroxides' could

have similar results to 'induces lipid peroxidation'. I thought

I would just come at it again afresh another day. (If you want

any references let me know. They are too tedious to put in if

they are not something you think you would look up).

* It is really annoying ,isn't it,that no-one else is

researching this? I was thinking though that it is just such an

obscure route to go with a respiratory type disease. Hopefully

some multidisciplinary symposium will flag it up as being

worthwhile.

* I have some information on epithalamin. It is a pineal

extract from cattle or pigs. I guess they test the animal

for infectious agents before they process it. A doctor in

Genova is selling it. But as you say I would be wary.

This is why I need to be referred to an endocrinology

consultant. There is now a synthetic analogue of

epithalamin called epitalon for which the developers are

currently applying for drug approval in Russia and the

United States. (Again I can provide references if anyone

would like to read more)

So, I have written enough for tonight! Great to have someone to thrash this out

with.

Thanks to all those who posted supportive comments. If not for you, and the

promise to reply to asfy, I may not have posted again.

What about my old friend Molyneaux, are you out out there old bean?

Goodnight, ine