unbelievable rash

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Hello-Just wanted some feedback, everyone on here is always so helpful. I have had this recurrent red rash for the past 20 years since the onset of my Samter's nightmare. It comes and goes and is very cyclical but the older I get it seems to come with a vengeance. I can go 6 months with nothing and then boom, every day! It always starts on my feet, makes its way up my legs to my hands and then swelling an joint tenderness as well as weezing come with it. Oddly enough it goes away when I sleep, rash free for the first 10 minutes of being awake and then it comes on. I cannot link it to medicine, it happens if I have been on an antibiotic or not. I have always just waited it out but this last episode I went to my doctor

(they never have any answers- it is idiosyncratic) but they gave me a cortisteroid shot and prednisone dose pack which brought me about 3 hours relief. I then went to the ER, they did the same with a bit stronger approach, again with a few hours relief. I am out of patience, how can this be so bad that steroids are not even getting rid of it? Is it a reaction to fungal infection, build up of salicytes, auto-immune response? Thanks,TylerFrom: Nils Bischoff <n_bischoff2001@...>samters Sent: Thu, August 19, 2010 6:58:12 PMSubject: Histamine intolerance

Just wanted to post this even Samter's and Histamine intolerance is not related there is still the possibility for an individual to have both. It says the prevalence is about 1% of the population but statistically there might be some histamine-intolerant persons in this group.e.g. some foods you should not consume when you are histamine intolerant:red winebeerhopstabak smoketeamany fruits+ many others as aged cheese, salami, ham http://www.ajcn.org/cgi/content/full/85/5/1185Am J Clin Nutr. 2007 May;85(5):1185-96.Histamine and histamine intolerance.Maintz L, Novak

N.Department of Dermatology, University of Bonn, Bonn, Germany.AbstractHistamine

intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine

toxicity. Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested histamine. It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release. Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells. An impaired histamine degradation based on

reduced DAO activity and the resulting histamine excess may cause numerous symptoms mimicking an allergic reaction. The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance. Symptoms can be

reduced by a histamine-free diet or be eliminated by antihistamines. However,

because of the multifaceted nature of the symptoms, the existence of histamine intolerance has been underestimated, and further studies based

on double-blind, placebo-controlled provocations are needed. In patients in whom the abovementioned symptoms are triggered by the corresponding substances and who have a negative diagnosis of allergy or

internal disorders, histamine intolerance should be considered as an underlying pathomechanism.These are very good links but unfortunately in German:http://www.nahrungsmittel-intoleranz.com/index.php?option=com_content & view=article & id=48 & Itemid=176http://de.wikipedia.org/wiki/Histamin-IntoleranzFoods are categorized

into 3 areas: High histamine foods, foods that support the histamine release and diaminoxidase blocking foods. (Diaminoxidase is the stuff which breaks down histamines).