reply to kate and all

[Guest guest]

Hi Kate, I have had a quick look at the website you suggested,I

didn't really understand the mechanism of action of the drug.

However, if it is blocking the action of a neurotransmitter between

the hours of 2am and 4am (nearly the time at which melatonin levels

peak)and also having side effects of sleep problems, then it may

interfere in some way with melatonin. Anyway, I will be very

interested to hear how you get on.

The reason why i am so interested in the russian paper is because it

is the first stab i have seen at getting to the root cause of what is

wrong with us. It actually tries to correct an imbalance that is the

root cause ,rather than just treating the symptoms. Even

desensitisation (if it works) is simply another treatment of the

symptoms. Chances are that our bodies will adapt to the new goalposts.

The reason why i mention migraine and psoriasis is because they are

also believed to be caused by changes in levels of the same hormone

family(An amino acid called tryptophan makes serotonin, serotonin

makes melatonin and melatonin breaks down to salicylic acid). Changes

in serotonin levels during the menstrual cycle can trigger a

migraine, is this also down to an oversensitivity?. Psoriasis is

known to be treated by sunlight, melatonin is inhibited by sunlight.

My rhinitis problems are worst in the early hours of the morning

(after melatonin peaks)and when i get up in the morning. If i sleep

too long , my problems are worse.

I noticed something very strange abou a year ago, I was given

amitryptilline (a tricyclic antidepressant)to treat irritable bowel

syndrom. It completely cured all my problems. I felt great, sense of

smell returned, rhinitis problems disappeared etc. This success

lasted for 6 months and then my problems returned. I tried a few

different antidepressent drugs immediately after with no success. 6

months later i tried amitryptilline again, it worked again, this time

for only 1-2 months. My specialist do not know why it worked (in fact

i'm not even sure that they believe me)They suggest that

amitryptilline has antihistamine effects (but why then would

antihistamines on their own have absolutely no effect?). Lots of

antidepressants do get involved with serotonin....could this have

anything to do with it?

Can anyone suggest how we could make this site easier to find. I have

seriously trawled the net for years without finding it,i am sure

there are others out there?

Does anyone know how we could go about setting up some kind of

database that we could insert information into. For example it would

be good to see at a glance how many people have had successful long

term desensitisations, how many react to paracetamol (an over the

counter pain killer in uk-called something different in america..it

is a weak cox inhibitor)?, how many have serotonin/melatonin related

disorders e.g migraine, psoriasis, ibs, compulsive obsesive disorder,

depression etc? How many get itchy ears? How many have polyps in ears

and how long it took before you got them? and so on.

[Guest guest]

> From: " pauline_newnham " <pauline_newnham@...>

> Reply-samters

> Date: Thu, 18 Dec 2003 12:21:34 -0000

> samters

> Subject: reply to kate and all

>

.. . . snip . . .

>

> Does anyone know how we could go about setting up some kind of

> database that we could insert information into. For example it would

> be good to see at a glance how many people have had successful long

> term desensitisations, how many react to paracetamol (an over the

> counter pain killer in uk-called something different in america..it

> is a weak cox inhibitor)?, how many have serotonin/melatonin related

> disorders e.g migraine, psoriasis, ibs, compulsive obsesive disorder,

> depression etc? How many get itchy ears? How many have polyps in ears

> and how long it took before you got them? and so on.

>

ine,

the " contacts " file in the group's " database " section was meant to be a

first crack at a database. Most of the things you have mentioned could be

squeezed in there somewhere, but I agree, there's a potential to expand it

and better organize it.

regards,

Ken West