RE: ACE Inhibitors

[Guest guest]

Karl, Thanks for the reference. I’m on theverge of having to change BP medicine (currently on beta blocker) so this isgood to know. It would be my luck to have gone to an ACE Inhibitor. Who knows?Maybe the association of ACE Inhibitors with arachidonic acid metabolism willeventually lead to discovery of a Samters cure. Jim From: Wuensch, Karl L[mailto:WuenschK@...] Sent: Thursday, August 26, 20049:44 AMsamters Subject: ACE Inhibitors Of possible interest to those on ACEinhibitors (I was taken off of them due to the dry cough that accompanied theiruse):http://www.medscape.com/viewarticle/484537?src=mpAlthough data are incomplete, it appears that angiotensin-convertingenzyme inhibitors cause cough and angioedema through a cascade of effects thatbegins with the accumulation of kinins, and then involves arachidonic acid metabolism andnitric oxide generation. Most patients who develop either cough or angioedemafrom angiotensin-converting enzyme inhibitors can tolerate angiotensin-IIreceptor blocking agents. ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~Karl L. Wuensch, Department of Psychology,East CarolinaUniversity, Greenville NC 27858-4353Voice: 252-328-4102 Fax: 252-328-6283WuenschK@...http://core.ecu.edu/psyc/wuenschk/klw.htm

[Guest guest]

Dear Karl

I cant get read the article-Do you know if there is a relationship between the angiotensin converting enzyme and aspirin, Salycilates or NSAIDS? do these affect this enzyme ?

"Wuensch, Karl L" <WuenschK@...> wrote:

Of possible interest to those on ACE inhibitors (I was taken off of them due to the dry cough that accompanied their use):

http://www.medscape.com/viewarticle/484537?src=mp

Although data are incomplete, it appears that angiotensin-converting enzyme inhibitors cause cough and angioedema through a cascade of effects that begins with the accumulation of kinins, and then involves arachidonic acid metabolism and nitric oxide generation. Most patients who develop either cough or angioedema from angiotensin-converting enzyme inhibitors can tolerate angiotensin-II receptor blocking agents.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~Karl L. Wuensch, Department of Psychology,East Carolina University, Greenville NC 27858-4353Voice: 252-328-4102 Fax: 252-328-6283WuenschK@...http://core.ecu.edu/psyc/wuenschk/klw.htm__________________________________________________

[Guest guest]

No, I do not know those details.

To be able to read the article, you have to register (free) with Medscape. I hate being forced to register all over the net, but I find Medscape worth the hassle.

Karl W.

Re: ACE Inhibitors

Dear Karl

I cant get read the article-Do you know if there is a relationship between the angiotensin converting enzyme and aspirin, Salycilates or NSAIDS? do these affect this enzyme ?

"Wuensch, Karl L" <WuenschK@...> wrote:

Of possible interest to those on ACE inhibitors (I was taken off of them due to the dry cough that accompanied their use):

http://www.medscape.com/viewarticle/484537?src=mp

Although data are incomplete, it appears that angiotensin-converting enzyme inhibitors cause cough and angioedema through a cascade of effects that begins with the accumulation of kinins, and then involves arachidonic acid metabolism and nitric oxide generation. Most patients who develop either cough or angioedema from angiotensin-converting enzyme inhibitors can tolerate angiotensin-II receptor blocking agents.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~Karl L. Wuensch, Department of Psychology,East Carolina University, Greenville NC 27858-4353Voice: 252-328-4102 Fax: 252-328-6283WuenschK@...http://core.ecu.edu/psyc/wuenschk/klw.htm

__________________________________________________

[Guest guest]

I second that on Medscape, it's a great resource.

Lori

> Of possible interest to those on ACE inhibitors (I was taken

off of them due to the dry cough that accompanied their use):

> http://www.medscape.com/viewarticle/484537?src=mp

> Although data are incomplete, it appears that angiotensin-

converting enzyme inhibitors cause cough and angioedema through a

cascade of effects that begins with the accumulation of kinins, and

then involves arachidonic acid metabolism and nitric oxide

generation. Most patients who develop either cough or angioedema from

angiotensin-converting enzyme inhibitors can tolerate angiotensin-II

receptor blocking agents.

>

>

> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

> Karl L. Wuensch, Department of Psychology,

> East Carolina University, Greenville NC 27858-4353

> Voice: 252-328-4102 Fax: 252-328-6283

> WuenschK@m...

> http://core.ecu.edu/psyc/wuenschk/klw.htm

> __________________________________________________

>