Re: Re: Another finding about the possible genetic roots of Samter's

[Guest guest]

Ok! I hope Nat does have a good Nat gene, for his sakes.

Becky :-)

From: asfy <asfyso@...>samters Sent: Sun, 11 July, 2010 17:44:15Subject: Re: Another finding about the possible genetic roots of Samter's

Note that Nat may still have a good Nat gene because Nat may be bad only in a Korean or Asian population... :-)>> )Â You gave me the biggest laugh of the day! I developed my Samters after I had > my second child - guess what his name is? Nat!> > Becky> > > > > ________________________________> From: asfy <asfyso@...>> samters > Sent: Sun, 11 July, 2010 17:09:24> Subject: Another finding about the possible genetic roots of Samter's> > Â > In this Korean study, a defect in

a particular gene called NAT2, which helps get > rid of leukotrienes, was associated with aspirin-intolerant asthma. > > > ------------> > Pharmacogenomics. 2010 Jul;11(7):951- 8.> Association analysis of N-acetyl transferase- 2 polymorphisms with aspirin > intolerance among asthmatics.> Kim JM, Park BL, Park SM, Lee SH, Kim MO, Jung S, Lee EH, Uh ST, Park JS, Choi > JS, Kim YH, Kim MK, Choi IS, Cho SH, Choi BW, Park HS, Chang HS, Shin HD, Park > CS.> Genome Research Center for Allergy & Respiratory Disease, Soonchunhyang > University Bucheon Hospital, 1174 Jung-dong, Wonmi-gu, Bucheon, Gyeonggi-do > 420-767, Republic of Korea.> Abstract> AIMS: Cysteinyl leukotrienes are inactivated by acetyl coenzyme

A-dependent > N-acetyltransferase (NAT). Thus, functional alterations of the NAT gene may > contribute to the risk of aspirin-intolerant asthma. MATERIALS & METHODS: > Asthmatics (n = 438) were categorized into aspirin-intolerant asthma (15% or > greater decrease in the forced expiratory volume in 1 s or cutaneous reactions, > n = 170) or aspirin-tolerant asthma (n = 268) groups. In total, 14 polymorphisms > of the NAT2 gene were genotyped by a single-base extension method. RESULTS: The > distributions of all loci of the 14 SNPs were in Hardy-Weinberg equilibrium (p > > 0.05). Among the 14 SNPs, six common SNPs (minor allele frequency >5%) in a > Korean population were used for haplotype construction and further statistical > analysis. The logistic regression analysis demonstrated that NAT2 -9246G>C and > haplotype 2 (TCACGG) were significantly associated with the

risk of > aspirin-intolerant asthma. The rare allele frequencies of the SNP and Ht2 were > significantly higher in the aspirin-intolerant asthma group than in the > aspirin-tolerant asthma group (p(corr) = 0.03 and p(corr) = 0.02 in codominant > model). CONCLUSION: In a large genetic epidemiology study of aspirin-intolerant > asthma in a Korean population, genetic polymorphisms of NAT2 were found to be > related to a risk of aspirin hypersensitivity among asthmatics.>