Re: melatonin breaks down to ASA?

[Guest guest]

Hi ine! I'm not trying to be picky about terminology, but there

are so many confusing things with this disorder that I think it's

important to speak about it precisely -- and endogenous means made

within the organism, so that's why it's confusing for me to use it

otherwise. It IS in the paper that our bodies supposedly respond

negatively to exogenous melatonin. That is the one part that I am

sure is in there.

I will definitely read it again, although I have a lot of skepeticism

about the article itself. Since I don't have much of a knowledge of

biology and chemistry, I really am not sure I understand about

endogenous aspirin and melatonin being broken down into

acetylsalicylic acid, and I can't find any primary resources about it

anywhere, except for the Russian paper.

It IS all so complicated, it's like we have to get a degree just to

understand what is going on in our bodies to try to help ourselves!

Thanks again

Lori

[Guest guest]

Hello All

I know it's been a while since I posted. I had to respond to this.

First I will tell you that I had my fourth sinus surgery one week

ago. My last surgery was nine years ago. My new surgeon is great.

I'm feeling very very well.

Anyway, I am fortunate enough to be a chemist. I never would have

imagined how handy that would be until I made the connection that my

problems were at least in part - chemical. I have examined the

structure of melatonin, and in the absence of either a mechanism or

expiremental evidence, I cannot believe that melatonin breaks down

into ASA or even salicylic acid. I will check a bit more, but this

seems to be a great stretch to me. Do they have a mechanism or any

experimental evidence?

Hope this helps.

Mike

> Hi ine! I'm not trying to be picky about terminology, but

there

> are so many confusing things with this disorder that I think it's

> important to speak about it precisely -- and endogenous means made

> within the organism, so that's why it's confusing for me to use it

> otherwise. It IS in the paper that our bodies supposedly respond

> negatively to exogenous melatonin. That is the one part that I am

> sure is in there.

>

> I will definitely read it again, although I have a lot of

skepeticism

> about the article itself. Since I don't have much of a knowledge

of

> biology and chemistry, I really am not sure I understand about

> endogenous aspirin and melatonin being broken down into

> acetylsalicylic acid, and I can't find any primary resources about

it

> anywhere, except for the Russian paper.

>

> It IS all so complicated, it's like we have to get a degree just

to

> understand what is going on in our bodies to try to help ourselves!

>

> Thanks again

>

> Lori

[Guest guest]

I wrote this before, one of the main reasons I am skeptical of the

paper is because the people who wrote it are selling a product.

And, sadly enough, we can't get the product outside of Russia anyway.

Likely not for a very long time. Maybe never. It's an injection and

so you couldn't even smuggle it out of the country or anything.

I have taken melatonin many times and never had any symptoms from it.

The doctors in your country sound great. In my experience with

doctors here, 90 percent or more of them are not interested in any

information I bring them. Many of them don't even believe Samters

syndrome exist, I've had doctors tell me that it's impossible to be

desensitized to aspirin. I've rarely had any doctor help me with

this syndrome at all, except when I had the desensitization done. I

know much much more than any of my doctors do about this because I've

educated myself. So, no, I'm not going to let my doctors analyze

this or do anything with it. I'm going to continue to educate myself

and debate about it here if people wish, for the point of furthering

our self-education.

And in my dream world some day I'll have a Samters or AERD foundation

and we'll be able to pay doctors to do more research and also educate

the doctors in the mainstream about Samters.

In the mean time I'm not going to rely on my doctors to tell me

anything about this, because they simply don't know anything.

It might be different if I could go to an endocrinologist, but the

way m;y insurance works and many people's works here is that you have

to get a referral to one, and no doctor will refer me because they

don't believe I have an endocrine disorder. I may disagree, but it

doesn't matter what I think.

Lori

[Guest guest]

P.S.

I think the leukotriene inhibitors do a lot more treat than just

treat the symptoms, actually.