Guest guest Posted January 20, 2010 Report Share Posted January 20, 2010 Thanks for this info -- very useful. On Jan 20, 2010, at 7:32 PM, stuffyintexas wrote: OK....here it goes.....hope I don't upset or offend anyone for posting this. About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself. DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did. After much research and planning, where's what I did: I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule: 7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial 8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions 9 am – take 1 ml of "aspirin water" (which is a very small amount) 10 am – take 5 ml 11 am – take 10 ml Noon – take 20 ml 1 pm – take 40 ml 2 pm – take 80 ml 3 pm – take 160 ml 4 pm – take another full aspirin (320 mg) orally So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled. I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day. Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years). Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction. DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier. I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 20, 2010 Report Share Posted January 20, 2010 with desensitization at the allergist they required that I quit taking any and all steroids at least 2 weeks prior to desensitization....including any nasal steroids. Bianca OK....here it goes.....hope I don't upset or offend anyone for posting this. About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself. DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did. After much research and planning, where's what I did: I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule: 7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial 8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions 9 am – take 1 ml of "aspirin water" (which is a very small amount) 10 am – take 5 ml 11 am – take 10 ml Noon – take 20 ml 1 pm – take 40 ml 2 pm – take 80 ml 3 pm – take 160 ml 4 pm – take another full aspirin (320 mg) orally So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled. I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day. Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years). Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction. DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier. I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 The way it is done here in England that is different, is that the whole process is much slower. When a person starts reacting to a dose 9which could be over an hour AFTER that does was given), then they are treated and that is it for the day -that dose is then repeated for one whole week (in the morning) until desens to that dose. then from there the following week, at the hospital, the doses then go up again step by step until another reaction occurs. I remember i first reacted to 40mg and then I reacterd to 80mg, an dthen i reacted to 300mg, and then finally i got up to 600mg and going from 300 to 600 was much easier than the initial stages. So it's a similar process just much slower. Becky From: joan harvey <thomyris7@...>samters Sent: Thu, 21 January, 2010 2:46:41Subject: Re: Self Desensitization Thanks for this info -- very useful.. On Jan 20, 2010, at 7:32 PM, stuffyintexas wrote: OK....here it goes.....hope I don't upset or offend anyone for posting this.About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself.DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did.After much research and planning, where's what I did:I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup).. Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule:7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions 9 am – take 1 ml of "aspirin water" (which is a very small amount)10 am – take 5 ml11 am – take 10 mlNoon – take 20 ml1 pm – take 40 ml2 pm – take 80 ml3 pm – take 160 ml4 pm – take another full aspirin (320 mg) orallySo as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled.I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day.Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years).Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction.DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier.I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 For those who may want to try your method, I think your reaction was more severe than necessary. I was desensitized in one day in an allergist's office. The method was similar but they waited 2 hours between doses. When I reacted we waited 4 hours then repeated the last dose. My sneezing and wheezing was gone before we resumed. I didn't react again. I'm not sure what they would have done if I did. The three hour idea is scary. The aspirin remains in your system for 4 hours. My reaction was not immediate, it took about an hour. The plan is to find the smallest dose that crosses the threshold so that the reaction is minimal and manageable. I'm urging more caution for anyone reading this who may want to try this at home. Pam stuffyintexas wrote: > OK....here it goes.....hope I don't upset or offend anyone for posting this. > > About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself. > > DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did. > > After much research and planning, where's what I did: > > I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of " aspirin water " into another glass, and drank it each hour on this schedule: > > 7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial > 8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions > 9 am – take 1 ml of " aspirin water " (which is a very small amount) > 10 am – take 5 ml > 11 am – take 10 ml > Noon – take 20 ml > 1 pm – take 40 ml > 2 pm – take 80 ml > 3 pm – take 160 ml > 4 pm – take another full aspirin (320 mg) orally > > So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled. > > I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day. > > Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years). > > Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction. > > DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. > > My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier. > > I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. > > > > > ------------------------------------ > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 You had a dangerous reaction in part because you did not leave enough time between doses, and you did not give yourself time to recover after the reaction started. The idea of using a solution to achieve very small dose is a good one (and is on file here), but, your accelerated technique is more dangerous than it needs to be, and should not be used as an example for people to avoid self-desensitization. > From: " stuffyintexas " <stuffyintexas@...> > > OK....here it goes.....hope I don't upset or offend anyone for posting this. > > About a year and a half ago, I did some research, and got brave (or stupid) > enough to do an aspirin desense to myself. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 I agree with Pam the method below does not indicate any of the repeat dosing that we did at the allergist. Nor does it space the dosing out long enough to have an adequate amount of response time to the aspiring. My procedure took about 3 days to become fully desensitized and it was not as harsh as the recommendation below. Bianca > OK....here it goes.....hope I don't upset or offend anyone for posting this.>> About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself.>> DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did.>> After much research and planning, where's what I did:>> I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule:>> 7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial> 8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions > 9 am – take 1 ml of "aspirin water" (which is a very small amount)> 10 am – take 5 ml> 11 am – take 10 ml> Noon – take 20 ml> 1 pm – take 40 ml> 2 pm – take 80 ml> 3 pm – take 160 ml> 4 pm – take another full aspirin (320 mg) orally>> So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled.>> I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day.>> Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years).>> Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction.>> DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. >> My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier.>> I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again.>>>>> ------------------------------------>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 The spacing on mine was somewhat different, but not significantly. I had a very bad reaction at 120mg -- which I think was mid-afternoon the first day. After I got through it, they upped the amount more that afternoon, and when I left the second day I was at the full 1350 dose. On Jan 21, 2010, at 1:50 PM, Bianca F wrote: I agree with Pam the method below does not indicate any of the repeat dosing that we did at the allergist. Nor does it space the dosing out long enough to have an adequate amount of response time to the aspiring. My procedure took about 3 days to become fully desensitized and it was not as harsh as the recommendation below. Bianca > OK....here it goes.....hope I don't upset or offend anyone for posting this.>> About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself.>> DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did.>> After much research and planning, where's what I did:>> I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule:>> 7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial> 8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions > 9 am – take 1 ml of "aspirin water" (which is a very small amount)> 10 am – take 5 ml> 11 am – take 10 ml> Noon – take 20 ml> 1 pm – take 40 ml> 2 pm – take 80 ml> 3 pm – take 160 ml> 4 pm – take another full aspirin (320 mg) orally>> So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled.>> I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day.>> Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years).>> Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction.>> DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. >> My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier.>> I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again.>>>>> ------------------------------------>> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 Thanks to all for all the great infos posted here. This is really a great forum. In New Zealand they also increase the dosis only every second day - so desens here takes ages. In Germany it takes 6 weeks and in other countries they desens within a day. Somehow I guess that a slower desens could be the safer way to do it?Not sure which daily doses is the right one to maintain the desens since there seem to be some arguments for different daily intakes between countries and doctors:Switzerland, Davos: 500mg dailyGermany: 500mg dailyNew Zealand: 300mg dailyUSA/ UK: 650mg or more daily?I recently read also a study which said that 100mg daily would be enough to reach a satisfying level of desens after 12 month. Does anybody have more information on this? I think nobody normally should take more then really necessary to reach the right level of comfort since Aspirin is still a poison for us?--- Bannister <beckyb256@...> schrieb am Do, 21.1.2010:Von: Bannister <beckyb256@...>Betreff: Re: Self DesensitizationAn: samters Datum: Donnerstag, 21. Januar 2010, 9:15 The way it is done here in England that is different, is that the whole process is much slower. When a person starts reacting to a dose 9which could be over an hour AFTER that does was given), then they are treated and that is it for the day -that dose is then repeated for one whole week (in the morning) until desens to that dose. then from there the following week, at the hospital, the doses then go up again step by step until another reaction occurs. I remember i first reacted to 40mg and then I reacterd to 80mg, an dthen i reacted to 300mg, and then finally i got up to 600mg and going from 300 to 600 was much easier than the initial stages. So it's a similar process just much slower. Becky From: joan harvey <thomyris7mac (DOT) com>samters@groups .comSent: Thu, 21 January, 2010 2:46:41Subject: Re: Self Desensitization Thanks for this info -- very useful.. On Jan 20, 2010, at 7:32 PM, stuffyintexas wrote: OK....here it goes.....hope I don't upset or offend anyone for posting this.About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself.DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly – you could stop breathing, like I almost did.After much research and planning, where's what I did:I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup).. Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of "aspirin water" into another glass, and drank it each hour on this schedule:7 am – prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial8 am – pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions 9 am – take 1 ml of "aspirin water" (which is a very small amount)10 am – take 5 ml11 am – take 10 mlNoon – take 20 ml1 pm – take 40 ml2 pm – take 80 ml3 pm – take 160 ml4 pm – take another full aspirin (320 mg) orallySo as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled.I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted – sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day.Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years).Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction.DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier.I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 Yes, before you go in for any allergy testing or de-sense, they want you to avoid any antihistamines as they can mask the histamine release when you are exposed to allergens, thus making the tests less accurate. When I get the various skin tests, they ask me to not take anything for 24-48 hours. > > > > > >  > > > > > > > > OK....here it goes.....hope I don't upset or offend anyone for posting this. > > > > About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself. > > > > DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly †" you could stop breathing, like I almost did. > > > > After much research and planning, where's what I did: > > > > I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup). Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of " aspirin water " into another glass, and drank it each hour on this schedule: > > > > 7 am †" prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial > > 8 am †" pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions > > 9 am †" take 1 ml of " aspirin water " (which is a very small amount) > > 10 am †" take 5 ml > > 11 am †" take 10 ml > > Noon †" take 20 ml > > 1 pm †" take 40 ml > > 2 pm †" take 80 ml > > 3 pm †" take 160 ml > > 4 pm †" take another full aspirin (320 mg) orally > > > > So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled. > > > > I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted †" sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the > last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair treatment, I went to bed. It was a long and scary day. > > > > Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years). > > > > Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction. > > > > DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. > > > > My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier. > > > > I read about a rapid (over a 3 hour period) that cardiologists do to administer aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 That's probably true. What also didn't help was the fact that I was running around the house doing chores while I was taking de-sense regiment, and when it hit me, my circulation was going strong. When I did another de-sense months later, I stayed laying down, and the reaction was not nearly as severe. It also probably helped to know what I was going to deal with. In any event, you are correct that it is probably not the best example to use for self desense. As with any procedure, there is always a chance you could have a severe reaction, and if you do, you want it to happen in a medical setting where there are trained people there to administer the correct meds to counter any reactions or perform any resuscitation. Jack > > You had a dangerous reaction in part because you did not leave enough time > between doses, and you did not give yourself time to recover after the > reaction started. > > The idea of using a solution to achieve very small dose is a good one (and > is on file here), > but, > your accelerated technique is more dangerous than it needs to be, and should > not be used as an example for people to avoid self-desensitization. > > > From: " stuffyintexas " <stuffyintexas@...> > > > > > OK....here it goes.....hope I don't upset or offend anyone for posting this. > > > > About a year and a half ago, I did some research, and got brave (or stupid) > > enough to do an aspirin desense to myself. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 21, 2010 Report Share Posted January 21, 2010 I'll second that. We have had some very good discussion on this, and shared some great information. Very courteous and professional group! I read somewhere that once de-sensitized, if a person stopped taking aspirin, they would be re-sensitized within 2 to 5 days. The liver has a lot to do with processing the aspirin. When I stopped taking aspirin after my first de-sense, my symptoms returned in about 2 days, so I had to be careful never to miss a day of aspirin. I had gone from 2 aspirin a day down to 2 a day, and then was breaking an aspirin into 4 pieces and taking a quarter with each meal and before I went to bed, and that seemed to work fine for me. When I was taking 2 a day, it was hard on my stomach, and if I scraped a knuckle at work, I bled like crazy. I think as long as there is a constant intake aspirin in your system (after going thru de-sense), then they body won't react to it. Not sure if anyone in this group is taking just an aspirin (320 mg) a day. > > >  > > > > OK....here it goes.....hope I don't upset or offend anyone for posting this. > > About a year and a half ago, I did some research, and got brave (or stupid) enough to do an aspirin desense to myself. > > DISCLAIMER - I don't recommend doing this yourself, as the reactions could be deadly †" you could stop breathing, like I almost did. > > After much research and planning, where's what I did: > > I dissolved an aspirin (320 mg) into 320 ml of water (using a kitchen measuring cup).. Then I used a device that looked like a large eye dropper (that held up to 10 ml of fluid), and measured out the following amounts of " aspirin water " into another glass, and drank it each hour on this schedule: > > 7 am †" prepare epi-pen, teach wife how to use it, have benadryl ready, 911 in speed dial > 8 am †" pre-medicate - take Advair inhaler, 20 mg of prednisone, and a 10 mg loratadine (claritin) to help reduce the allergic reactions > 9 am > †" take 1 ml of " aspirin water " (which is a very small amount) > 10 am †" take 5 ml > 11 am †" take 10 ml > Noon †" take 20 ml > 1 pm †" take 40 ml > 2 pm †" take 80 ml > 3 pm †" take 160 ml > 4 pm †" take another full aspirin (320 mg) orally > > So as you see, by 3 pm, I had taken almost 320 mg of aspirin (a full aspirin), and by 4 pm, 2 full aspirin. I made sure to stir the solution each time so the aspirin was equally distributed in the water. Every ml of water contains 1 mg of aspirin. It was a simple way to get the amounts exact. Notice that each hour the dose is essentially doubled. > > I read the average person reacted when the intake was about 80 mg, and sure enough, that is when I reacted †" sometime just after the 1 pm dose. I had been walking around the house like nothing was going on, and even thought that I was not allergic to aspirin, but at some point, my chest began to get tight and I developed trouble breathing. I > took the rescue inhaler multiple times, but it didn't help a bit. The reaction worsened to the point that any movement I did aggravated the situation, so I took 2 benadryl and laid down in bed, and was scared to death. It felt like someone had tightened a belt around my chest so tight that I couldn't inhale. Nothing like I had ever experienced before. I sort of fell asleep (due to the benadryl), and about an hour or so later, woke up with a massive headache, congested like I had never been congested, but I continued the treatment by going up to the next dose. A couple of hours later, after I had taken the last aspirin (bringing the total to 640 mg, or 2 full aspirin), I was able to breathe a bit better, but was badly congested. I took a shower and tried blowing my nose, but that wasn't much relief. I went to lay down, and slept until about 8 pm, and woke up feeling a bit better, but still had a headache. After eating a bit and taking another Advair > treatment, I went to bed. It was a long and scary day. > > Woke up the next morning, blew all sorts of stuff out of my nose, and behold, could actually slightly smell coffee (that's how I tested my sense of smell, by sticking my nose in a can of coffee grounds). I continued by taking 2 full aspirins a day for about a month, and then dropped to 1 aspirin a day for a month, then continued by breaking the aspirin into 4 pieces and taking 1 piece 4 times a day. That really helped my stomach. And foods tasted fantastic! (after being without a sense of smell for over 3 years). > > Where I went wrong was not staying in bed and staying still while going thru the treatment. I was going around the house doing normal things, and when I reacted, it hit me hard and fast. I got some sort of stomach flu while out of town months later, so I stopped taking aspirin and got re-sensitized. The second time I desensed myself, I knew to lay down and lay still, and since > I knew when it was coming, I was ready for it and didn't panic as much. Still had the severe trouble breathing followed by the massive headache, but knew it was temporary, and again, the next day things were fine. I did follow-on desense the second day, and had no reaction. > > DISCLAIMER - Again, I don't recommend anyone doing this themselves, especially if you have a tendency to panic when you have an asthma attack. I'm sure each person will react differently, and if the reaction is severe enough, the ambulance won't get there fast enough to do anything for you. > > My allergy doctor said I was crazy. I may do it again once I get off these blood thinners, but I also don't want to be taking aspirin (salycitic acid) the rest of my life. It simply cannot be good. So I'm going to keep up with avoiding my allergy triggers, drink lots of water, and eat healthier. > > I read about a rapid (over a 3 hour period) that cardiologists do to administer > aspirin to their patients who need to be catheterized but are allergic to aspirin, so this same regiment can probably be used, but on a shorter time period (taking the doses every 30 minutes instead of every hour). I will probably use the 3 hour treatment if I desense myself again. > > > > > > > > > > > > > > > > > > > > > > > > > > > __________________________________________________ > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2010 Report Share Posted January 22, 2010 100 mg would uphold desensitization but would not help with Samter's inflammation. There are papers by Dr. son in the files that discuss his studies on dosage. Nils Bischoff wrote: > > > Thanks to all for all the great infos posted here. This is really a > great forum. > > In New Zealand they also increase the dosis only every second day - so > desens here takes ages. In Germany it takes 6 weeks and in other > countries they desens within a day. Somehow I guess that a slower > desens could be the safer way to do it? > > Not sure which daily doses is the right one to maintain the desens > since there seem to be some arguments for different daily intakes > between countries and doctors: > > Switzerland, Davos: 500mg daily > Germany: 500mg daily > New Zealand: 300mg daily > USA/ UK: 650mg or more daily? > > I recently read also a study which said that 100mg daily would be > enough to reach a satisfying level of desens after 12 month. Does > anybody have more information on this? I think nobody normally should > take more then really necessary to reach the right level of comfort > since Aspirin is still a poison for us? > > -- > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 22, 2010 Report Share Posted January 22, 2010 I actually referred to a study of the University of Muenster, Germany from 2008 which was presented on the 79. meeting of the german ENT association, called 'Orale und nasale Aspirin-Desaktivierung mittels täglicher, niedrig dosierter ASS-Gabe bei Samter-Trias' (~low doses oral and nasal desens of samters trias patients)The results of this study were eg. that less then 5% of the trial patients who took a daily oral doses of 100mg ASS got new polyps in the first year. (0% of the trial patients which were daily treated with a specific low nasal doses of topical ASS got new polyps) ...and patients generally felt better - I think there are a lot of different opinions on the daily doses.--- Pamela <pam@...> schrieb am Fr, 22.1.2010:Von: Pamela <pam@...>Betreff: Re: Self DesensitizationAn: samters Datum: Freitag, 22. Januar 2010, 13:50 100 mg would uphold desensitization but would not help with Samter's inflammation. There are papers by Dr. son in the files that discuss his studies on dosage. Nils Bischoff wrote: > > > Thanks to all for all the great infos posted here. This is really a > great forum. > > In New Zealand they also increase the dosis only every second day - so > desens here takes ages. In Germany it takes 6 weeks and in other > countries they desens within a day. Somehow I guess that a slower > desens could be the safer way to do it? > > Not sure which daily doses is the right one to maintain the desens > since there seem to be some arguments for different daily intakes > between countries and doctors: > > Switzerland, Davos: 500mg daily > Germany: 500mg daily > New Zealand: 300mg daily > USA/ UK: 650mg or more daily? > > I recently read also a study which said that 100mg daily would be > enough to reach a satisfying level of desens after 12 month. Does > anybody have more information on this? I think nobody normally should > take more then really necessary to reach the right level of comfort > since Aspirin is still a poison for us? > > -- > __________________________________________________ Quote Link to comment Share on other sites More sharing options...
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