Re: maintenace vs threshold

[Guest guest]

I was on prednisone, but a low dose, for only two days, I think 20 mg. They gave me much more prednisone after I reacted -- which I think did help me get through. I certainly was properly desensitized while on prednisone, and I don't know how I would have got through without it. But it also does seem possible that it may have raised the threshold at which I react. Hard to say, as I don't particularly want to test the situation. On Jun 10, 2010, at 4:26 PM, q2 wrote:

> From: joan harvey <thomyris7@...>

> I'm wondering about your science -- what evidence to you have that 81 mg is

> enough for everyone.

I carefully said that this was "my experience" -- my evidence is my own

experience. That, in itself, as usual, does not necessarily apply to

everyone, but, it is my experience. I thnk my main point here is that you

can stay desensitized at doses lower than the usually defined maintenance

doses.

> For example I didn't have a reaction to aspirin until

> 120 mg (and at that stage had a very bad reaction) and I seriously doubt that

> 81mg would have worked to desensitize me.

Yes, 120mg is probably above average of the reports here (unless you were

doing Prednsisone at the same time). And, I was not equating a minimum

maintenance dose with the threshold dose; however, once desensitized, I

believe (without specific evidence) that you can remain desensitized with

doses lower than the threshold dose.

I was not thinking of my threshold dose, which was in fact, as I recall, 80

mg. So, this is actually an interesting question -- I wonder if others

here have observations on that, specifically:

IS THE THRESHOLD DOSE EQUAL TO

THE MINIMUM MAINTENANCE DOSE?

btw -- were you in fact on Prednisone during desens?

[Guest guest]

This is a very interesting question - especially for me at the moment.

I answered the recent poll about reaction dose - and mine was <80mg (I think it was a 75 mg dose that I reacted to) and I wasn't taking prednisolone.

At the moment I am taking a 150mg daily dose of aspirin for 2 weeks prior to an operation.....I really want to contact my Immunologistst (allergist) and ask him if i could be on a lower daily dose for the 2 weeks as I am concerned that this dose is too high for my op to be successfullly completed without me bleeding too much for the op to be aborted midway (which I absolutely DON'T want, as it's being dose 4 hours away and has taken me about 2 years to psych myself up for this op).

It is reassuring from an earlier post that someone was able to be on 350mg for 1 week then nothing for 2 days before the op and her op go smoothly....but I know I have dreadful problems with clotting while on aspirin as I bruise terribly at the slightest knock and if I give myself the tiniest cut, I bleed for ages, which is so annoying.

I guess i should trust my Dr's with this one, but I know they were both compromising as the ENT said 75mg was the highest dose he's normally happy operation on, and my Immunologist didn't want me going below 150mg. I feel like piggy in the middle, and if I wasn't so in control of my meds and managing my condition then i'd be more happy just to do what my Dr's say..but my gut feeling is that 150mg will be too high a dose for my op to go smoothly and I really should be owering it more, or going off my aspirin altogether for this period and re-desens in a month or so.

Thanks for 'listening' and sorry to go on about this, but it is really concerning me at the moment.

Becky

From: q2 <kenwest@...>samters Sent: Thu, 10 June, 2010 23:26:43Subject: maintenace vs threshold

> From: joan harvey <thomyris7@...>> I'm wondering about your science -- what evidence to you have that 81 mg is> enough for everyone.I carefully said that this was "my experience" -- my evidence is my ownexperience. That, in itself, as usual, does not necessarily apply toeveryone, but, it is my experience. I thnk my main point here is that youcan stay desensitized at doses lower than the usually defined maintenancedoses.> For example I didn't have a reaction to aspirin until> 120 mg (and at that stage had a very bad reaction) and I seriously doubt that> 81mg would have worked to desensitize me.Yes, 120mg is probably above average of the reports here (unless you weredoing Prednsisone at the same time). And, I was not equating a minimummaintenance dose with the

threshold dose; however, once desensitized, Ibelieve (without specific evidence) that you can remain desensitized withdoses lower than the threshold dose.I was not thinking of my threshold dose, which was in fact, as I recall, 80mg. So, this is actually an interesting question -- I wonder if othershere have observations on that, specifically:IS THE THRESHOLD DOSE EQUAL TOTHE MINIMUM MAINTENANCE DOSE?btw -- were you in fact on Prednisone during desens?

[Guest guest]

Hi Becky

I would stop taking any aspiring before surgery, just to be on the safe side.

You could have a large hemorrhage just from 30 mg. I'd say trust your ENT, the

surgery comes first.

Sergiu

>

> This is a very interesting question - especially for me at the moment.

> I answered the recent poll about reaction dose - and mine was <80mg (I think

it was a 75 mg dose that I reacted to) and I wasn't taking prednisolone.

>

> At the moment I am taking a 150mg daily dose of aspirin for 2 weeks prior to

an operation.....I really want to contact my Immunologistst (allergist) and ask

him if i could be on a lower daily dose for the 2 weeks as I am concerned that

this dose is too high for my op to be successfullly completed without me

bleeding too much for the op to be aborted midway (which I absolutely DON'T

want, as it's being dose 4 hours away and has taken me about 2 years to psych

myself up for this op).

>

> It is reassuring from an earlier post that someone was able to be on 350mg for

1 week then nothing for 2 days before the op and her op go smoothly....but I

know I have dreadful problems with clotting while on aspirin as I bruise

terribly at the slightest knock and if I give myself the tiniest cut, I bleed

for ages, which is so annoying.

>

> I guess i should trust my Dr's with this one, but I know they were both

compromising as the ENT said 75mg was the highest dose he's normally happy

operation on, and my Immunologist didn't want me going below 150mg. I feel like

piggy in the middle, and if I wasn't so in control of my meds and managing my

condition then i'd be more happy just to do what my Dr's say..but my gut feeling

is that 150mg will be too high a dose for my op to go smoothly and I really

should be owering it more, or going off my aspirin altogether for this period

and re-desens in a month or so.

>

> Thanks for 'listening' and sorry to go on about this, but it is really

concerning me at the moment.

> Becky

>

>

>

>

> ________________________________

> From: q2 <kenwest@...>

> samters

> Sent: Thu, 10 June, 2010 23:26:43

> Subject: maintenace vs threshold

>

>  

> > From: joan harvey <thomyris7@...>

> > I'm wondering about your science -- what evidence to you have that 81 mg is

> > enough for everyone.

> I carefully said that this was " my experience " -- my evidence is my own

> experience. That, in itself, as usual, does not necessarily apply to

> everyone, but, it is my experience. I thnk my main point here is that you

> can stay desensitized at doses lower than the usually defined maintenance

> doses.

>

> > For example I didn't have a reaction to aspirin until

> > 120 mg (and at that stage had a very bad reaction) and I seriously doubt

that

> > 81mg would have worked to desensitize me.

> Yes, 120mg is probably above average of the reports here (unless you were

> doing Prednsisone at the same time). And, I was not equating a minimum

> maintenance dose with the threshold dose; however, once desensitized, I

> believe (without specific evidence) that you can remain desensitized with

> doses lower than the threshold dose.

> I was not thinking of my threshold dose, which was in fact, as I recall, 80

> mg. So, this is actually an interesting question -- I wonder if others

> here have observations on that, specifically:

> IS THE THRESHOLD DOSE EQUAL TO

> THE MINIMUM MAINTENANCE DOSE?

>

> btw -- were you in fact on Prednisone during desens?

>

[Guest guest]

I react from 40 to 60 mg ASA but have no IgE mediated reactions. So as Ken does

I have desensitized myself to ASA many times ,after first being desensitized

under supervision of an Allergist near an emergency department of a hospital.

>

> > From: Nils Bischoff <n_bischoff2001@...>

> > Date: Fri, 11 Jun 2010 01:49:55 +0000 (GMT)

> > may I ask you at how many mg of Aspirin you had your first mayor reaction

> > during desense?

> somewhere between 40 and 80. I started a " survey " for others to record

> theirs.

>

> >I would assume that the maintenance dosis should be above this

> > threshold which may vary from person to person.

>

> That is a reasonable asumption, but I think it should be verified.

> I feel strongly that once desensitized, things are not the same as before.

> It couild be that once desenitized, a small amount of aspirin suffices. I

> do agree, however, that the normal maintenance doses (650-1300) are

> necessary to get the benefits of desensitization, (re polyps, SoS, etc.)

>

> > I saw that the Medical facility of the University of Munich, Germany states

> > that you are supposed to be desensed for 12 Month and that afterwards it

does

> > not need to be continued since then salicylates in food could be tolerated.

> > Others mention it should be continued for the rest of our lives. Any

opinions

> > on this?

> I personally don't pay much attention to dietary salicylates -- it has not

> been an issue for me and and any dietary modifications that I have made have

> not had any effect on symptoms. On the other hand, I am pretty sure that

> if you stop taking maintenance doses of aspirin, you will have an intolerant

> reaction the next time you do.

> >

>