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- Sheila

Analysis of serum lipid profiles metal

ions and thyroid hormones levels abnormalities in beta-thalassaemic children of

Bangladesh.

Pak Med Assoc.

2010 May;60(5):360-4.

Novartis Limited, Bangladesh.

Abstract

OBJECTIVE:

To assess the serum lipid profile of cardiovascular disease free male and

female children with beta-thalassaemia. Levels of zinc, copper and magnesium in

the serum were also determined along with the Thyroid profile.

METHODS:

From January to December 2007, we enrolled 121 consecutive patients with

beta-thalassaemia that visited The Thalassaemia Center at Dhaka Shishu

(Children) Hospital, Bangladesh every month for routine examinations. Fasting

blood lipid levels were measured in all participants. Zinc, Copper and Magnesium levels in serums were determined.

Thyroid function was also assessed by evaluating T3, T4 and TSH levels.

RESULTS:

Of the 121 patients, 65 were males (10.14 +/- 3.91 years) and 56 were females

(9.08 +/- 4.32 years). Data analysis revealed that 2.0% males and 4.35% females

had high total serum cholesterol, and 28.57% males and 21.74% females had high

triglyceride levels. In addition, mean HDL-cholesterol levels were 21.14 +/-

5.82 mg/dl in males and 21.17 +/- 6.02 mg/dl in females; total-cholesterol to

HDL-cholesterol ratios were 5.47 +/- 1.66 and 5.96 +/- 2.81 in males and

females respectively. About 60% patients showed low serum

level of Zn

and Cu. Hypothyroidism

was detected in 30% patients and 23% patients had abnormal experimental values of all the study

parameters.

CONCLUSIONS: The majority of the patients had blood lipid levels (by

the exception of HDL-cholesterol) within the normal range, and consequently the

prevalence of lipid abnormalities was much lower as compared to the general

population of the same age. Interestingly, the total-cholesterol to

HDL-cholesterol ratio was high in our patients, and may underline the

importance of this index for the prognosis of future cardiac events in these

patients. The serum Zn and Cu levels were low in

most of the patients which may cause some metabolic abnormalities in future.

Most [?] of the patients also showed hypothyroidism

indicating the presence of endocrine complications.

PMID:

20527607 [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/20527607