Guest guest Posted February 7, 2010 Report Share Posted February 7, 2010 Hi , I'll give it a shot. A methyl group is one carbon and three hydrogens. It is used by the body to perform various functions. It is quite important and there are five main cycles of the methylation pathway. The fifth cycle is called the methylation cycle (of the methylation pathway) and it deals with cysteine and glutathione (this cycle also deals with sulfur). That is what most people are talking about when they say methylation but methylation is used in the other cycles and are important too. Here is a diagram of the methylation pathway - way over to the right and down all the way is the end product of the 5th cycle - glutathione. This is a key element that most of us are deficient in as the body has used it up to deal with our trigger. In the past, we tried using whey or injections to increase the levels of glutathione - not very successful because as soon as you stop, the levels drop again. The source of the problem is upstream. http://www.knowyourgenetics.com/The%20Methylation%20Pathway_files/diagram-1.jpg Here is a diagram of just the 5th cycle - the one that feeds glutathione. Homocysteine is what the body uses to make glutathione. http://www.knowyourgenetics.com/The%20Methylation%20Pathway_files/basicmethylati\ on-1.jpg " In the chemical sciences, methylation denotes the addition of a methyl group to a substrate or the substitution of an atom or group by a methyl group. Methylation is a form of alkylation with specifically a methyl group, rather than a larger carbon chain, replacing a hydrogen atom. These terms are commonly used in chemistry, biochemistry, soil science, and the biological sciences. In biological systems, methylation is catalyzed by enzymes; such methylation can be involved in modification of heavy metals, regulation of gene expression, regulation of protein function, and RNA metabolism. " Dr. Amy Yasko has done a lot of research (primarily with autistic children) and Rich Van Konynenberg followed up on that and found that ME/CFIDS folks have similar biochemistry. So, there is a group called CFS_Yasko which deals with the full protocol (Yasko) and the Simplified protocol (Rich Van K) to try to restore these cycles. HTH, Marti > > Could someone tell me and explain to me what methylation is. I tried to find a good description and I am just not finding it. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 > > Hi , > I'll give it a shot. > > A methyl group is one carbon and three hydrogens. It is used by the body to perform various functions. It is quite important and there are five main cycles of the methylation pathway. The fifth cycle is called the methylation cycle (of the methylation pathway) and it deals with cysteine and glutathione (this cycle also deals with sulfur). Marti, Thanks for explaining it to me. Way over my head! So, what is done to achieve methylation, or in easier terms how would it help? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 8, 2010 Report Share Posted February 8, 2010 Hi , Basically, the body uses methyl groups (one carbon atom and 3 hydrogen atoms) to " do " things like help detox the body, repair cell walls, process hormones, create neurotranmitters. So many of the symptoms of ME/CFIDS can be traced to poor methylation - like poor sleep (not enough serotonin), mild to full on depression (not enough dopamine), poor stress reaction (too much norepinephrine), neurological issues (demyelination of nerve endings), suppressed immune system causing reactivated viruses as well as opportunistic infections, etc. In the past, ME/CFIDS researchers focused on glutathione either by injections (Dr. Salvato) or by ingesting undenatured whey (Dr. Cheney). But these didn't work well or the results didn't last. So some researchers moved upstream to find the causes of low glutathione. Dr. Rich Van Konynenberg has been instrumental in tying the work of Dr. Yasko and other autism doctors to our population. There are amazing similarities. Other doctors/researchers are now looking into methylation to find the cause of various illnesses. This is now moving mainsteam. I was able to get one of the genes tested by Labcorp - the MTHFR gene through Medicare for me and through Humana for my son. HTH, feel free to ask more questions. Marti > > > > Hi , > > I'll give it a shot. > > > > A methyl group is one carbon and three hydrogens. It is used by the body to perform various functions. It is quite important and there are five main cycles of the methylation pathway. The fifth cycle is called the methylation cycle (of the methylation pathway) and it deals with cysteine and glutathione (this cycle also deals with sulfur). > > Marti, > > Thanks for explaining it to me. Way over my head! So, what is done to achieve methylation, or in easier terms how would it help? > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 9, 2010 Report Share Posted February 9, 2010 - Rich posted methylation info in the 'files' section on this site. Doug > > Could someone tell me and explain to me what methylation is. I tried to find a good description and I am just not finding it. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 8, 2010 Report Share Posted July 8, 2010 The benefit of having Dr. Yasko's suggested gene test for methylation is that it can help one determine what supplements might benefit you more. Some people that can't get well despite trying many things have the CBS upregulation. The test would show you this. There are things you can do to control this and need to control or your chances of improving might be hindered. This is off topic, so if interested you can google Dr. Amy Yasko and read more. I have the CBS upregulation and it explains to me why alot of my past efforts at improving my health have not paid off. Deb Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 10, 2010 Report Share Posted July 10, 2010 I don't care so much about what people think of Yasko -- a lot of alternative folks get trashed & criticized. (And a lot of folks foolishly pad their resume, thinking it makes them look more competent.) But I read up on her approach, & it is fiendishly complicated & expensive, & it amounts to a RIDICULOUS number of supplements. I have heard claims that she has helped people on autism lists, & anybody that can help with autism deserves at least some brownie points. But most of us wouldn't find her protocol practical.AnneOn Jul 9, 2010, at 7:39 AM, Graciela Gomez wrote: http://www.maloneymedical.com/id86.html I belive you should read the info about Yasko in this link. Nirvana From: migde12000 <MigDe1@...>Subject: Re: Methylationiodine Received: Thursday, July 8, 2010, 6:38 PM For a detailed explanation of the supplements see the CFS Yasko group. There are posts and also files, etc. to explain everything. Some people there have had the tests, but alot haven't and are just trying the supplements. Deb> > > > The benefit of having Dr. Yasko's suggested gene test for methylation is that it can help one determine what supplements might benefit you more. Some people that can't get well despite trying many things have the CBS upregulation. The test would show you this. > > There are things you can do to control this and need to control or your chances of improving might be hindered. This is off topic, so if interested you can google Dr. Amy Yasko and read more. I have the CBS upregulation and it explains to me why alot of my past efforts at improving my health have not paid off. Deb> Quote Link to comment Share on other sites More sharing options...
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