lyme, radioactive iodine and the blood brain barrier

September 23, 2010

Hello,

I think this reads that iodine crosses the blood brain barrier which could mean

that iodine would be the optimal treatment for lyme or any other pathogen that

attacks the brain. Am I reading this correctly?

Thanks,

Joan

What happens when the infection gets to the brain?

In the case of Lyme disease every animal model to date shows, that the Lyme

spirochete

can go from the site of the bite, to the brain in just a few days. (41,60,

abstract 644) While

we know this bacteria can breakdown individual cell membranes, and capillaries,

its entrance into the brain is too pronounced for such a localized effect. When

the Lyme bacteria enters the human body, we react by producing several immune

regulatory substances known as cytokines and lymphokines. Several of these act

in concert to break down the blood brain barrier. (eg. Il-6, Tumor Necrosis

Factor-alpha, Il-1, Transforming Growth Factor-beta etc. )

In addition to affecting the blood brain barrier, these cytokines can make us

feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

Since the brain has no immune system, it prevents infection by limiting what can

enter

the brain. The capillary bed that surrounds the brain, is so tight that not even

white blood

cells are allowed to enter. Many drugs can't enter either, making treatment of

the brain

especially hard. For the first ten days of a Lyme infection, the blood brain

barrier is virtually non existent. This not only allows the Lyme bacteria to get

in, but also immune cells that can cause inflammation of the brain. (41, see

LDSM 95 for diagram)

*Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin, and

other

substances known not to cross the BBB with radioactive Iodine. The CSF was

tested, and

then the animals were infected with Bb. Then the CSF was tested everyday for

several weeks.

The result: No cross over of Iodine in the control group, 100% crossover in the

infected group for 10 days. The infection had the same result on the BBB, as if

you were injecting the radioactive iodine directly into the brain. (60)

When the human brain becomes inflamed, cells called macrophages respond by

releasing

a neuro-toxin called quinolinic acid. This toxin is also elevated in Parkinson's

Disease, MS,

ALS, and is responsible for the dementia that occurs in AIDS patients. What

quinolinic acid

does, is to stimulate neurons to repeatedly depolarize. This eventually causes

the neurons

to demyelinate and die. People with elevated quinolinic acid have short term

memory

problems. (27,29-37,40-42,74,75, 82-84,87-90)

http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

September 23, 2010

Joan,

Sorry – but it appears that this

article is stating that Iodine does NOT readily cross the blood brain barrier

UNLESS one’s brain is under attack by a disease that causes our own

immune system to react by producing substances that break down the blood brain

barrier.

“The result: No cross

over of Iodine in the control group, 100% crossover in the infected group for

10 days. The infection had the same result on the BBB, as if you were injecting

the radioactive iodine directly into the brain. (60)”

So, then one wonders – well, what about giving Iodine after the

fact, after one determines they have been infected by Lymes? Well, it

depends how long the blood brain barrier remains broken down by the immune

system response. Unfortunately, the article alludes to this breakdown in

the BBB as ceasing after a point, or at least reducing, it is unclear.

“For the first ten days of a Lyme infection, the blood brain

barrier is virtually non existent. This not only allows the Lyme bacteria to

get in, but also immune cells that can cause inflammation of the brain. (41,

see LDSM 95 for diagram)”

De

\

From:

iodine [mailto:iodine ] On Behalf Of coloredoctave

Sent: Thursday, September 23, 2010

4:38 PM

iodine

Subject: lyme,

radioactive iodine and the blood brain barrier

Hello,

I think this reads that iodine crosses the blood brain barrier which could mean

that iodine would be the optimal treatment for lyme or any other pathogen that

attacks the brain. Am I reading this correctly?

Thanks,

Joan

What happens when the infection gets to the brain?

In the case of Lyme disease every animal model to date shows, that the Lyme

spirochete

can go from the site of the bite, to the brain in just a few days. (41,60,

abstract 644) While

we know this bacteria can breakdown individual cell membranes, and capillaries,

its entrance into the brain is too pronounced for such a localized effect. When

the Lyme bacteria enters the human body, we react by producing several immune

regulatory substances known as cytokines and lymphokines. Several of these act

in concert to break down the blood brain barrier. (eg. Il-6, Tumor Necrosis

Factor-alpha, Il-1, Transforming Growth Factor-beta etc. )

In addition to affecting the blood brain barrier, these cytokines can make us

feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

Since the brain has no immune system, it prevents infection by limiting what

can enter

the brain. The capillary bed that surrounds the brain, is so tight that not

even white blood

cells are allowed to enter. Many drugs can't enter either, making treatment of

the brain

especially hard. For the first ten days of a Lyme infection, the blood brain

barrier is virtually non existent. This not only allows the Lyme bacteria to

get in, but also immune cells that can cause inflammation of the brain. (41,

see LDSM 95 for diagram)

*Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin, and

other

substances known not to cross the BBB with radioactive Iodine. The CSF was

tested, and

then the animals were infected with Bb. Then the CSF was tested everyday for

several weeks.

The result: No cross over of Iodine in the control group, 100% crossover in the

infected group for 10 days. The infection had the same result on the BBB, as if

you were injecting the radioactive iodine directly into the brain. (60)

When the human brain becomes inflamed, cells called macrophages respond by

releasing

a neuro-toxin called quinolinic acid. This toxin is also elevated in

Parkinson's Disease, MS,

ALS, and is responsible for the dementia that occurs in AIDS patients. What

quinolinic acid

does, is to stimulate neurons to repeatedly depolarize. This eventually causes

the neurons

to demyelinate and die. People with elevated quinolinic acid have short term

memory

problems. (27,29-37,40-42,74,75, 82-84,87-90)

http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

September 23, 2010

On 9/23/2010 3:00 PM, Deanna Buck Floyd wrote:

Sorry

– but it appears that this

article is stating that Iodine does NOT readily cross the

blood brain barrier

UNLESS one’s brain is under attack by a disease that causes

our own

immune system to react by producing substances that break down

the blood brain

barrier.

Hm. That's bad new for me since I've been told that the mercury I

have stored (which is a huge amount) is mostly in my brain. Well.

I do take cilantro -- which is supposed to cross the blood brain

barrier -- so I can only hope that the iodine will help cart away

whatever the cilantro releases.

September 24, 2010

De,

I understood that part, that it didn't work in the control group but it seems

possible when one is under attack.

Does this mean, however, that one could take iodine immediately following a

bite, during that 10 day period to kill the spirochette or stop it from entering

the brain?

It makes me wonder if one could be treated with a new bite (under supervision)

to open up the blood brain barrier, in order to open the door for iodine or

other treatments.

Crossing the BBB is a huge obstacle. Cat's Claw is the herb that is used but I

want iodine to work.

Wishful thinking,

Joan

>

> Joan,

>

> Sorry - but it appears that this article is stating that Iodine does NOT

> readily cross the blood brain barrier UNLESS one's brain is under attack by

> a disease that causes our own immune system to react by producing substances

> that break down the blood brain barrier.

>

> " The result: No cross over of Iodine in the control group, 100% crossover in

> the infected group for 10 days. The infection had the same result on the

> BBB, as if you were injecting the radioactive iodine directly into the

> brain. (60) "

>

> So, then one wonders - well, what about giving Iodine after the fact, after

> one determines they have been infected by Lymes? Well, it depends how long

> the blood brain barrier remains broken down by the immune system response.

> Unfortunately, the article alludes to this breakdown in the BBB as ceasing

> after a point, or at least reducing, it is unclear.

>

> " For the first ten days of a Lyme infection, the blood brain barrier is

> virtually non existent. This not only allows the Lyme bacteria to get in,

> but also immune cells that can cause inflammation of the brain. (41, see

> LDSM 95 for diagram) "

>

> De

>

> \

>

> _____

>

> From: iodine [mailto:iodine ] On Behalf Of

> coloredoctave

> Sent: Thursday, September 23, 2010 4:38 PM

> iodine

> Subject: lyme, radioactive iodine and the blood brain barrier

>

> Hello,

>

> I think this reads that iodine crosses the blood brain barrier which could

> mean that iodine would be the optimal treatment for lyme or any other

> pathogen that attacks the brain. Am I reading this correctly?

>

> Thanks,

> Joan

>

> What happens when the infection gets to the brain?

>

> In the case of Lyme disease every animal model to date shows, that the Lyme

> spirochete

> can go from the site of the bite, to the brain in just a few days. (41,60,

> abstract 644) While

> we know this bacteria can breakdown individual cell membranes, and

> capillaries, its entrance into the brain is too pronounced for such a

> localized effect. When the Lyme bacteria enters the human body, we react by

> producing several immune regulatory substances known as cytokines and

> lymphokines. Several of these act in concert to break down the blood brain

> barrier. (eg. Il-6, Tumor Necrosis Factor-alpha, Il-1, Transforming Growth

> Factor-beta etc. )

>

> In addition to affecting the blood brain barrier, these cytokines can make

> us feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

>

> Since the brain has no immune system, it prevents infection by limiting what

> can enter

> the brain. The capillary bed that surrounds the brain, is so tight that not

> even white blood

> cells are allowed to enter. Many drugs can't enter either, making treatment

> of the brain

> especially hard. For the first ten days of a Lyme infection, the blood brain

> barrier is virtually non existent. This not only allows the Lyme bacteria to

> get in, but also immune cells that can cause inflammation of the brain. (41,

> see LDSM 95 for diagram)

>

> *Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin, and

> other

> substances known not to cross the BBB with radioactive Iodine. The CSF was

> tested, and

> then the animals were infected with Bb. Then the CSF was tested everyday for

> several weeks.

>

> The result: No cross over of Iodine in the control group, 100% crossover in

> the infected group for 10 days. The infection had the same result on the

> BBB, as if you were injecting the radioactive iodine directly into the

> brain. (60)

>

> When the human brain becomes inflamed, cells called macrophages respond by

> releasing

> a neuro-toxin called quinolinic acid. This toxin is also elevated in

> Parkinson's Disease, MS,

> ALS, and is responsible for the dementia that occurs in AIDS patients. What

> quinolinic acid

> does, is to stimulate neurons to repeatedly depolarize. This eventually

> causes the neurons

> to demyelinate and die. People with elevated quinolinic acid have short term

> memory

> problems. (27,29-37,40-42,74,75, 82-84,87-90)

>

> http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

>

September 24, 2010

Just talked to someone who has been treating brain cancer so basically her insurance has paid 300,000 this year for brain surgery and chemotherapy for various treatments including this. To cross the Blood brain barrier, she has MRI, IV port, medicine to protect her hearing and so on. Not simple, not cheap and not easily done but it is possible to do. Wish there were easy answers for these complex problems. Pam

On Fri, Sep 24, 2010 at 12:20 PM, coloredoctave <joanlulich@...> wrote:

De,

I understood that part, that it didn't work in the control group but it seems possible when one is under attack.

Does this mean, however, that one could take iodine immediately following a bite, during that 10 day period to kill the spirochette or stop it from entering the brain?

It makes me wonder if one could be treated with a new bite (under supervision) to open up the blood brain barrier, in order to open the door for iodine or other treatments.

Crossing the BBB is a huge obstacle. Cat's Claw is the herb that is used but I want iodine to work.

Wishful thinking,

Joan

>

> Joan,

>

> Sorry - but it appears that this article is stating that Iodine does NOT

> readily cross the blood brain barrier UNLESS one's brain is under attack by

> a disease that causes our own immune system to react by producing substances

> that break down the blood brain barrier.

>

> " The result: No cross over of Iodine in the control group, 100% crossover in

> the infected group for 10 days. The infection had the same result on the

> BBB, as if you were injecting the radioactive iodine directly into the

> brain. (60) "

>

> So, then one wonders - well, what about giving Iodine after the fact, after

> one determines they have been infected by Lymes? Well, it depends how long

> the blood brain barrier remains broken down by the immune system response.

> Unfortunately, the article alludes to this breakdown in the BBB as ceasing

> after a point, or at least reducing, it is unclear.

>

> " For the first ten days of a Lyme infection, the blood brain barrier is

> virtually non existent. This not only allows the Lyme bacteria to get in,

> but also immune cells that can cause inflammation of the brain. (41, see

> LDSM 95 for diagram) "

>

> De

>

> \

>

> _____

>

> From: iodine [mailto:iodine ] On Behalf Of

> coloredoctave

> Sent: Thursday, September 23, 2010 4:38 PM

> iodine

> Subject: lyme, radioactive iodine and the blood brain barrier

>

> Hello,

>

> I think this reads that iodine crosses the blood brain barrier which could

> mean that iodine would be the optimal treatment for lyme or any other

> pathogen that attacks the brain. Am I reading this correctly?

>

> Thanks,

> Joan

>

> What happens when the infection gets to the brain?

>

> In the case of Lyme disease every animal model to date shows, that the Lyme

> spirochete

> can go from the site of the bite, to the brain in just a few days. (41,60,

> abstract 644) While

> we know this bacteria can breakdown individual cell membranes, and

> capillaries, its entrance into the brain is too pronounced for such a

> localized effect. When the Lyme bacteria enters the human body, we react by

> producing several immune regulatory substances known as cytokines and

> lymphokines. Several of these act in concert to break down the blood brain

> barrier. (eg. Il-6, Tumor Necrosis Factor-alpha, Il-1, Transforming Growth

> Factor-beta etc. )

>

> In addition to affecting the blood brain barrier, these cytokines can make

> us feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

>

> Since the brain has no immune system, it prevents infection by limiting what

> can enter

> the brain. The capillary bed that surrounds the brain, is so tight that not

> even white blood

> cells are allowed to enter. Many drugs can't enter either, making treatment

> of the brain

> especially hard. For the first ten days of a Lyme infection, the blood brain

> barrier is virtually non existent. This not only allows the Lyme bacteria to

> get in, but also immune cells that can cause inflammation of the brain. (41,

> see LDSM 95 for diagram)

>

> *Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin, and

> other

> substances known not to cross the BBB with radioactive Iodine. The CSF was

> tested, and

> then the animals were infected with Bb. Then the CSF was tested everyday for

> several weeks.

>

> The result: No cross over of Iodine in the control group, 100% crossover in

> the infected group for 10 days. The infection had the same result on the

> BBB, as if you were injecting the radioactive iodine directly into the

> brain. (60)

>

> When the human brain becomes inflamed, cells called macrophages respond by

> releasing

> a neuro-toxin called quinolinic acid. This toxin is also elevated in

> Parkinson's Disease, MS,

> ALS, and is responsible for the dementia that occurs in AIDS patients. What

> quinolinic acid

> does, is to stimulate neurons to repeatedly depolarize. This eventually

> causes the neurons

> to demyelinate and die. People with elevated quinolinic acid have short term

> memory

> problems. (27,29-37,40-42,74,75, 82-84,87-90)

>

> http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

>

September 24, 2010

Why wouldn't iodine cross the BBB? Would the results have been different if

they had given high doses of vitamin C for two weeks first?

If the blood goes through the thyroid every 17 minutes, wouldn't the blood from

the brain pass through also? Iodine needn't go into the BBB if it is passing

through the thyroid.

So, blood goes through the BBB?

As you can see, I know nothing but sometimes common sense can give one answers.

Joan

> > >

> > > Joan,

> > >

> > > Sorry - but it appears that this article is stating that Iodine does NOT

> > > readily cross the blood brain barrier UNLESS one's brain is under attack

> > by

> > > a disease that causes our own immune system to react by producing

> > substances

> > > that break down the blood brain barrier.

> > >

> > > " The result: No cross over of Iodine in the control group, 100% crossover

> > in

> > > the infected group for 10 days. The infection had the same result on the

> > > BBB, as if you were injecting the radioactive iodine directly into the

> > > brain. (60) "

> > >

> > > So, then one wonders - well, what about giving Iodine after the fact,

> > after

> > > one determines they have been infected by Lymes? Well, it depends how

> > long

> > > the blood brain barrier remains broken down by the immune system

> > response.

> > > Unfortunately, the article alludes to this breakdown in the BBB as

> > ceasing

> > > after a point, or at least reducing, it is unclear.

> > >

> > > " For the first ten days of a Lyme infection, the blood brain barrier is

> > > virtually non existent. This not only allows the Lyme bacteria to get in,

> > > but also immune cells that can cause inflammation of the brain. (41, see

> > > LDSM 95 for diagram) "

> > >

> > > De

> > >

> > > \

> > >

> > > _____

> > >

> > > From: iodine <iodine%40> [mailto:

> > iodine <iodine%40>] On Behalf Of

> > > coloredoctave

> > > Sent: Thursday, September 23, 2010 4:38 PM

> > > iodine <iodine%40>

> > > Subject: lyme, radioactive iodine and the blood brain barrier

> > >

> > > Hello,

> > >

> > > I think this reads that iodine crosses the blood brain barrier which

> > could

> > > mean that iodine would be the optimal treatment for lyme or any other

> > > pathogen that attacks the brain. Am I reading this correctly?

> > >

> > > Thanks,

> > > Joan

> > >

> > > What happens when the infection gets to the brain?

> > >

> > > In the case of Lyme disease every animal model to date shows, that the

> > Lyme

> > > spirochete

> > > can go from the site of the bite, to the brain in just a few days.

> > (41,60,

> > > abstract 644) While

> > > we know this bacteria can breakdown individual cell membranes, and

> > > capillaries, its entrance into the brain is too pronounced for such a

> > > localized effect. When the Lyme bacteria enters the human body, we react

> > by

> > > producing several immune regulatory substances known as cytokines and

> > > lymphokines. Several of these act in concert to break down the blood

> > brain

> > > barrier. (eg. Il-6, Tumor Necrosis Factor-alpha, Il-1, Transforming

> > Growth

> > > Factor-beta etc. )

> > >

> > > In addition to affecting the blood brain barrier, these cytokines can

> > make

> > > us feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

> > >

> > > Since the brain has no immune system, it prevents infection by limiting

> > what

> > > can enter

> > > the brain. The capillary bed that surrounds the brain, is so tight that

> > not

> > > even white blood

> > > cells are allowed to enter. Many drugs can't enter either, making

> > treatment

> > > of the brain

> > > especially hard. For the first ten days of a Lyme infection, the blood

> > brain

> > > barrier is virtually non existent. This not only allows the Lyme bacteria

> > to

> > > get in, but also immune cells that can cause inflammation of the brain.

> > (41,

> > > see LDSM 95 for diagram)

> > >

> > > *Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin,

> > and

> > > other

> > > substances known not to cross the BBB with radioactive Iodine. The CSF

> > was

> > > tested, and

> > > then the animals were infected with Bb. Then the CSF was tested everyday

> > for

> > > several weeks.

> > >

> > > The result: No cross over of Iodine in the control group, 100% crossover

> > in

> > > the infected group for 10 days. The infection had the same result on the

> > > BBB, as if you were injecting the radioactive iodine directly into the

> > > brain. (60)

> > >

> > > When the human brain becomes inflamed, cells called macrophages respond

> > by

> > > releasing

> > > a neuro-toxin called quinolinic acid. This toxin is also elevated in

> > > Parkinson's Disease, MS,

> > > ALS, and is responsible for the dementia that occurs in AIDS patients.

> > What

> > > quinolinic acid

> > > does, is to stimulate neurons to repeatedly depolarize. This eventually

> > > causes the neurons

> > > to demyelinate and die. People with elevated quinolinic acid have short

> > term

> > > memory

> > > problems. (27,29-37,40-42,74,75, 82-84,87-90)

> > >

> > http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

> > >

> >

>

September 24, 2010

I know I am answering my own mail but I found this.

Changes in Blood-Brain Barrier Nutrient Transport in the Offspring of

Iodine-Deficient Rats and Their Preventability

Y. Sunitha, P. Udaykumar and M. Raghunath

Journal Article

Effect of iodinated contrast media on thyroid function in adultsAartJ. van der

Molen

no access

Abstract

Thyroid hormones affect the structure and function of biological membranes.

Whether or not they affect the Blood-Brain Barrier nutrient transport, the rate

limiting membrane transport regulating nutrient supply to brain is to be

established yet. That the impaired brain development and function seen in iodine

deficiency could be due to such an effect has been assessed in situ by the brain

uptake index (BUI) method in Wistar/NIN rat pups born to dams subjected to

dietary iodine deficiency/rehabilitation for different times.

2-Deoxy-D-Glucose (2-DG) and L-leucine (Leu) in the pups (D1) born to dams

chronically fed low iodine test (LIT) diet through their active growth and

subsequent pregnancy and lactation.

Surprisingly transport of L-Tyrosine (Tyr) and sucrose (the background marker)

was not altered, nor was the BBB transport of all these nutrients affected by

feeding LIT diet during the mothers' gestation (D2) and lactation (D3) only. The

hypothyroidism in D1 pups was only moderate and preventable by rehabilitation of

mothers with control diet from conception (R1) or parturition (R2), as were the

changes in BBB nutrient transport. The results suggest that chronic material

dietary iodine deficiency impairs BBB nutrient transport in the offspring and

this could be prevented by their rehabilitation with iodine.

http://www.springerlink.com/content/t0m674h5j16k1374/

http://curezone.com/forums/fm.asp?i=1691251#i

Here is part of the CureZone post. I am posting it because different

combinations of iodine and iodide interest me. Some bodies might require

different doses.

" I'm taking only 25 mg of the Iodoral with 6 drops of the SSKI. So far it seems

that more is better (for me at least these last couple of days)... meaning 205mg

overall. As long as I keep the Iodoral on the low end w/SSKI making up the bulk

of the dosage. "

" ABSTRACTBUY THE PDF

Pubmed abstract

Get permission

Buy the PDF

PDF from publisher

Suppl. info

HTML version

PMID: 15752899

PURPOSE: Synchrotron stereotactic radiotherapy (SSR) is a binary cancer

treatment modality that involves the selective accumulation of a high Z element,

such as iodine, in tumors, followed by stereotactic irradiation with kilovoltage

X-rays from a synchrotron source. The success of SSR is directly related to the

absolute amount of iodine achievable in the tumor. The purposes of this

preclinical study were to determine whether the delivery of iodine to brain

tumor models in rats could be enhanced by the means of its intracarotid

injection with or without a hyperosmotic solution and to evaluate corresponding

absorbed X-ray doses. METHODS AND MATERIALS: Experiments were performed on four

groups of F98 glioma-bearing rats, which received either intracarotid (IC) or

intravenous (IV) infusions of a mixture (6 mL in 12 min) of an iodinated

contrast agent associated or not with a transient blood-brain barrier opener

(mannitol). The mixture volumetric proportions were 8/13 of Iomeron (C = 350

mg/mL) for 5/13 of mannitol or saline, respectively. Absolute iodine

concentration kinetic was measured in vivo in the tumor, blood, contralateral

and ipsilateral brain, and muscle by monochromatic computed tomography.

Associated dosimetry was performed by computing the iodine dose enhancement

factor (DEF) in each region and building dose distribution maps by analytical

simulations. RESULTS: Infusion of mannitol significantly enhanced iodine tumor

uptake compared with the control values (p < 0.0001 and p = 0.0138, for IC and

0.98 mg/mL (DEF = 4.1) after administration of iodine and mannitol vs. 4.1 +/-

1.2 mg/mL i.c. with serum (DEF = 1.6). The tumor iodine uptakes after jugular

injection with mannitol (C = 4.4 +/- 2.1 mg/mL, DEF = 1.7) were not

significantly different from IC injection of iodine without mannitol (p =

0.8142). The IV injection of iodine with saline led to an iodine concentration

in the tumor of 1.2 +/- 0.98 mg/mL and a DEF of 1.2. CONCLUSIONS: This study

established that optimizing the delivery of iodine by means of IC injection

combined with a blood-brain barrier opener (mannitol) significantly increases

the iodine uptake of F98 rat gliomas. This infusion protocol could potentially

enhance the efficacy of SSR treatment, because the radiation dose is

proportional to the iodine amount present in the irradiation bed. DOI:

10.1016/j.ijrobp.2004.12.026 "

http://pubget.com/search?q=authors%3A%22Jean-FranÃ§ois%20Adam%22

Sorry, for such a long post.

Joan

> > > >

> > > > Joan,

> > > >

> > > > Sorry - but it appears that this article is stating that Iodine does NOT

> > > > readily cross the blood brain barrier UNLESS one's brain is under attack

> > > by

> > > > a disease that causes our own immune system to react by producing

> > > substances

> > > > that break down the blood brain barrier.

> > > >

> > > > " The result: No cross over of Iodine in the control group, 100%

crossover

> > > in

> > > > the infected group for 10 days. The infection had the same result on the

> > > > BBB, as if you were injecting the radioactive iodine directly into the

> > > > brain. (60) "

> > > >

> > > > So, then one wonders - well, what about giving Iodine after the fact,

> > > after

> > > > one determines they have been infected by Lymes? Well, it depends how

> > > long

> > > > the blood brain barrier remains broken down by the immune system

> > > response.

> > > > Unfortunately, the article alludes to this breakdown in the BBB as

> > > ceasing

> > > > after a point, or at least reducing, it is unclear.

> > > >

> > > > " For the first ten days of a Lyme infection, the blood brain barrier is

> > > > virtually non existent. This not only allows the Lyme bacteria to get

in,

> > > > but also immune cells that can cause inflammation of the brain. (41, see

> > > > LDSM 95 for diagram) "

> > > >

> > > > De

> > > >

> > > > \

> > > >

> > > > _____

> > > >

> > > > From: iodine <iodine%40> [mailto:

> > > iodine <iodine%40>] On Behalf Of

> > > > coloredoctave

> > > > Sent: Thursday, September 23, 2010 4:38 PM

> > > > iodine <iodine%40>

> > > > Subject: lyme, radioactive iodine and the blood brain barrier

> > > >

> > > > Hello,

> > > >

> > > > I think this reads that iodine crosses the blood brain barrier which

> > > could

> > > > mean that iodine would be the optimal treatment for lyme or any other

> > > > pathogen that attacks the brain. Am I reading this correctly?

> > > >

> > > > Thanks,

> > > > Joan

> > > >

> > > > What happens when the infection gets to the brain?

> > > >

> > > > In the case of Lyme disease every animal model to date shows, that the

> > > Lyme

> > > > spirochete

> > > > can go from the site of the bite, to the brain in just a few days.

> > > (41,60,

> > > > abstract 644) While

> > > > we know this bacteria can breakdown individual cell membranes, and

> > > > capillaries, its entrance into the brain is too pronounced for such a

> > > > localized effect. When the Lyme bacteria enters the human body, we react

> > > by

> > > > producing several immune regulatory substances known as cytokines and

> > > > lymphokines. Several of these act in concert to break down the blood

> > > brain

> > > > barrier. (eg. Il-6, Tumor Necrosis Factor-alpha, Il-1, Transforming

> > > Growth

> > > > Factor-beta etc. )

> > > >

> > > > In addition to affecting the blood brain barrier, these cytokines can

> > > make

> > > > us feel ill, and give us fevers. (54,60,) (JID 1996:173, Jan)

> > > >

> > > > Since the brain has no immune system, it prevents infection by limiting

> > > what

> > > > can enter

> > > > the brain. The capillary bed that surrounds the brain, is so tight that

> > > not

> > > > even white blood

> > > > cells are allowed to enter. Many drugs can't enter either, making

> > > treatment

> > > > of the brain

> > > > especially hard. For the first ten days of a Lyme infection, the blood

> > > brain

> > > > barrier is virtually non existent. This not only allows the Lyme

bacteria

> > > to

> > > > get in, but also immune cells that can cause inflammation of the brain.

> > > (41,

> > > > see LDSM 95 for diagram)

> > > >

> > > > *Note: The breakdown of BBB was shown to occur by tagging WBCs, albumin,

> > > and

> > > > other

> > > > substances known not to cross the BBB with radioactive Iodine. The CSF

> > > was

> > > > tested, and

> > > > then the animals were infected with Bb. Then the CSF was tested everyday

> > > for

> > > > several weeks.

> > > >

> > > > The result: No cross over of Iodine in the control group, 100% crossover

> > > in

> > > > the infected group for 10 days. The infection had the same result on the

> > > > BBB, as if you were injecting the radioactive iodine directly into the

> > > > brain. (60)

> > > >

> > > > When the human brain becomes inflamed, cells called macrophages respond

> > > by

> > > > releasing

> > > > a neuro-toxin called quinolinic acid. This toxin is also elevated in

> > > > Parkinson's Disease, MS,

> > > > ALS, and is responsible for the dementia that occurs in AIDS patients.

> > > What

> > > > quinolinic acid

> > > > does, is to stimulate neurons to repeatedly depolarize. This eventually

> > > > causes the neurons

> > > > to demyelinate and die. People with elevated quinolinic acid have short

> > > term

> > > > memory

> > > > problems. (27,29-37,40-42,74,75, 82-84,87-90)

> > > >

> > >

http://www.borelioza.org/materialy_lyme/the_complexities_of_lyme_disease.pdf

> > > >

> > >

> >

>

September 25, 2010

I don't think it's so hard to get iodine into the brain, b/c I felt

it working there very early on--taking 50mg Iodoral.

Gracia

On 9/24/2010 3:20 PM, coloredoctave wrote:

De,

I understood that part, that it didn't work in the control

group but it seems possible when one is under attack.

Does this mean, however, that one could take iodine

immediately following a bite, during that 10 day period to

kill the spirochette or stop it from entering the brain?

It makes me wonder if one could be treated with a new bite

(under supervision) to open up the blood brain barrier, in

order to open the door for iodine or other treatments.

Crossing the BBB is a huge obstacle. Cat's Claw is the

herb that is used but I want iodine to work.

Wishful thinking,

Joan

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