Re: where went idophobia?

[Guest guest]

So why are we taking Lugol's, if it blocks the release of T3 & T4 from the

Thyroid? Is that only for a short time, or only when in a TS, or what? I'm sure

they just order it from the pharmacy. THEY don't have any trouble getting it

cause they're PRACTICING physicians. BTW, I also thought it was interesting they

said not to give aspirin, cause it increases the assimilation of TH into the

cells. But, I was confused cause they said Hydrocortisone blocks absorbtion. I

had been lead to believe cortisol was essential in order for TH to get into the

cells. Can you clarify any of this?

BTW, its also interesting in a life threatening emergency they say screw the

tests, treat the symptoms.Thats because Dr.'s are focused so much on test

results due to CYA.NOT pt. care.Jim

>

> Interesting articles from medical sources.

> All three, in an extreme medical emergency that can be life threatening say:

>

> " First, you'll administer propylthiouracil (also called PTU) or methimazole

(Tapazole).1 Propylthiouracil is the preferred drug. In addition to preventing

the production of more T4 and T3 in the thyroid, it blocks the conversion of T4

to T3 outside of the thyroid, resulting in a rapid reduction in the level of

circulating hormone.5 Methimazole blocks the production of T4 and T3, but it

does not prevent T4 from converting to T3, so it takes longer to reduce the

level of circulating thyroid hormone. Because both drugs are available only in

oral form, they must be administered by mouth or feeding tube

>

> " Neither of these drugs, however, blocks the in-between step -- that is, the

step prior to conversion, when stored T4 and T3 are released from the thyroid.

To block their release, you'll need to wait at least an hour after giving

propylthiouracil or methima- zole and administer inorganic iodide --

>

> either Lugol's solution or saturated solution of potassium iodide (Pima,

SSKI).4

>

> If you give the iodide too soon after the propylthiouracil or methimazole, the

body will use the iodide to produce more T4. The inorganic iodides are available

only in an oral preparation. ... "

>

> So lugol's is " poison " but perfectly safe when needed looks like. Wonder if

they have a clue where to get it...

>

> Bruce

>

[Guest guest]

----- Original Message -----

From: dutchdivco

So why are we taking Lugol's, if it blocks the release of T3 & T4 from the

Thyroid? Is that only for a short time, or only when in a TS, or what?

---Interactions or something, I have them saved/flagged for future reference

when I have time to go through them more.

I'm sure they just order it from the pharmacy. THEY don't have any trouble

getting it cause they're PRACTICING physicians.

---as long as they don't " practice " on me.

BTW, I also thought it was interesting they said not to give aspirin, cause

it increases the assimilation of TH into the cells.

---Yes, interesting I seen that, hmmm...

But, I was confused cause they said Hydrocortisone blocks absorbtion. I had

been lead to believe cortisol was essential in order for TH to get into the

cells. Can you clarify any of this?

---Nope, not at present.

BTW, its also interesting in a life threatening emergency they say screw the

tests, treat the symptoms.

--- Noticed that yes, no time in these cases to test b4 treatment.

Thats because Dr.'s are focused so much on test results due to CYA.NOT pt.

care.

Jim

Bruce

[Guest guest]

I found a couple mentions of that, enough to look into.

A search on it works,

google: Hydrocortisone blocks t4;

" P.P.P.S. Er, yet again to Ronnie, but pharmacologic doses (that

is, greater than what the body produces naturally....say 40mg plus)

of adrenal cortisol (aka hydrocortisone) actually impair T4 to T3

conversion. "

Another:

" High hydrocortisone blocks conversion of T4-->active T3. So depending on

how much HC you were taking, your body might have had a build-up of T4 and

grew accustomed to producing quite a bit of it (maybe why your TSH and T4

were high at the same time).

When you tapered off the HC, suddenly all that T4 could convert to T3 more

easily and you got hyperT symptoms: shaking, insomnia, anxiety (although

hypOT can cause anxiety), rapid pounding heart.

I don't know how long the body takes to re-adjust TSH production to lower HC

levels tho. I also don't know how HC affects natural adrenal output of

cortisol during and after HC supplementation. May want to look into it. "

Bruce

----- Original Message -----

From: dutchdivco

But, I was confused cause they said Hydrocortisone blocks absorbtion. I had

been lead to believe cortisol was essential in order for TH to get into the

cells. Can you clarify any of this?

[Guest guest]

Regarding iodine and corticosteroids I found some useful info at:

http://www.auburn.edu/~deruija/endo_thyroiddrugs.pdf

" At one time the primary therapy available for hyperthyroidism such as Grave's

disease was iodide. Iodine-containing agents (eg, potassium iodide, Lugol's

solution) in the short term inhibit

thyroid hormone release, inhibit thyroid hormone biosynthesis and decrease the

size and vascularity of the thyroid gland. The phenomenon of iodine-inhibited

organification of thyroid hormones is known as the Wolff-Chaikoff effect. It is

an autoregulatory mechanism to protect the gland from excess production of

thyroid hormones in the presence of a large iodine load. The gland escapes this

mechanism within a few days of iodine ingestion because of leakage and/or

altered transport of iodine. The effects of iodides are overcome by TSH levels

that increase in response to lower plasma levels of free thyroid hormone. Thus

the iodide-suppressive effects on thyroid hormone release are overcome within 7

to 14 days

" Patients most likely to respond to iodides are those with high intrathyroidal

iodide levels or toxic adenoma, those on lithium, and some with Hashimoto's

thyroiditis. "

They also say that corticosteroids lower thyroglobulin concentration and (total)

thyroid hormone concentration by inhibiting thyroxine 5-deiodinase, which

converts T4 to T3. However free T3, T4 and rT3 are normal and the patient is

euthroid.

Charlotte.

So why are we taking Lugol's, if it blocks the release of T3 & T4 from the

Thyroid? Is that only for a short time, or only when in a TS, or what?

....

But, I was confused cause they said Hydrocortisone blocks absorbtion. I had been

lead to believe cortisol was essential in order for TH to get into the cells.

Can you clarify any of this?