thyroid peroxidase antibodies vs. thyroglobulin antibodies? & other concerns for Hashi child

[Guest guest]

Can someone please tell me the difference between thyroid peroxidase antibodies and thyroglobulin antibodies?

The blood test results for my 11-yr-old son w/ Hashi's is:

Thyroid peroxidase Antibodies: >1000 IU/mL

Thyroglobulin Antibodies: 179 IU/mL

TSH: 5.05 mIU/L

T-4 Total: 7.0 mcg/dL

T-3 Total: 160 ng/dL

We see the endocrinologist on Thursday. Can or some of you other very knowledgeable members give any advice on what to ask? Our son feels fine and is otherwise healthy and energetic. He has a corn allergy and does show a swelling of his thyroid/neck. He gets puffy under eyes sometimes, but that seems to be when corn "gets in" by accident. (Corn seems to be in just about everything these days!) He takes Iodoral and other supporting supplements (daily multi vit, B complex, extra C, selenium). He has normal basal temps (regularly 97.9 - 98.1)

He has never taken a thyroid supplement, though original endo prescribed Synthroid in summer 2008 with diagnosis (we never gave it to him because worried about synthetic ingredients and he feels fine). Didn't like that doctor so now going to someone new.

Our concern with this visit is that our son is on the brink of that 12-13 yr old growth spurt that our 2 older kids had, and I fear that he will not have what he needs from his thyroid to get through that and grow all that he should. He already is slightly small for his age, very trim and athletic, kinda like a track runner. Anyone have any experience with this type situation?

I would like to continue with just supplements, but if he needs the thyroid hormone we would like Nature-Throid because it is natural and I understand it is the only one without cornstarch.

I welcome all advice and ideas, and please correct me if I am wrong about anything here. I am all ears...well, actually eyes, since I will be READING your responses!

Thank you so much,

~Kim in PA

[Guest guest]

This is from my website:

Once inside the cell iodide is oxidized into iodine. This means that one electron has been dropped. This process occurs with the reaction of hydrogen peroxide (H2O2) with thyroperoxidase (TPO). Abnormalities here can cause the body to create Anti-TPO antibodies. This leads to Hashimoto's diseaseTransported iodine is organified as Thyroglobulin (Tg) on the rough endoplasmic reticulum by the action of thyroperoxidases (TPO), which is an enzyme that when expressed liberates iodine for the covalent bonding to tyrosine (an amino acid) residue on thyroglobulin forming monoiodotyrosine (MIT) and diiodotyrosine (DIT) or Iodotyrosines.

If that doesn't make sense just think of it in terms of your body creating an antibody that attacks the process dropping one electron (TPO Ab) and then against the process of binding iodine, tyrosine and thyroglobulin (Tg) - Tg Ab.

I can't tell much from the Total numbers. I prefer to look at Free's as they are unbound hormones available for use. As for the antibodies. Our doctor told me that antibodies generally don't show up until puberty. From that point on they will attack the thyroid and try to destroy it unless something is done to stop it. His TSH looks too high to me. I wish I could see the frees. My children had TSH of 1.3 yet their Frees were at the bottom of the ranges. My son (10) is very thin too. Hormonally he is going to be more challenged if his thyroid is truly low. How much iodoral is your son on? My 10 year old is on 25 mgs. Maybe he could use some more. I can't think of anything to ask the endo. Maybe check his iron / ferritin and B12 levels as they are usually low during growth spurts.

Endo's aren't the easiest doctors to deal with outside of the box on thyroids.'

Steph

thyroid peroxidase antibodies vs. thyroglobulin antibodies? & other concerns for Hashi child

Can someone please tell me the difference between thyroid peroxidase antibodies and thyroglobulin antibodies?

The blood test results for my 11-yr-old son w/ Hashi's is:

Thyroid peroxidase Antibodies: >1000 IU/mL

Thyroglobulin Antibodies: 179 IU/mL

TSH: 5.05 mIU/L

T-4 Total: 7.0 mcg/dL

T-3 Total: 160 ng/dL

We see the endocrinologist on Thursday. Can or some of you other very knowledgeable members give any advice on what to ask? Our son feels fine and is otherwise healthy and energetic. He has a corn allergy and does show a swelling of his thyroid/neck. He gets puffy under eyes sometimes, but that seems to be when corn "gets in" by accident. (Corn seems to be in just about everything these days!) He takes Iodoral and other supporting supplements (daily multi vit, B complex, extra C, selenium). He has normal basal temps (regularly 97.9 - 98.1)

He has never taken a thyroid supplement, though original endo prescribed Synthroid in summer 2008 with diagnosis (we never gave it to him because worried about synthetic ingredients and he feels fine). Didn't like that doctor so now going to someone new.

Our concern with this visit is that our son is on the brink of that 12-13 yr old growth spurt that our 2 older kids had, and I fear that he will not have what he needs from his thyroid to get through that and grow all that he should. He already is slightly small for his age, very trim and athletic, kinda like a track runner. Anyone have any experience with this type situation?

I would like to continue with just supplements, but if he needs the thyroid hormone we would like Nature-Throid because it is natural and I understand it is the only one without cornstarch.

I welcome all advice and ideas, and please correct me if I am wrong about anything here. I am all ears...well, actually eyes, since I will be READING your responses!

Thank you so much,

~Kim in PA