Candida research

[Guest guest]

Dear listmembers,

You may find this interesting....

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Science Daily

October 8, 2007

How A Benign Fungus Can Become Life-Threatening

Researchers at the Agency for Science, Technology and Research's Institute

of Molecular and Cell Biology have discovered new molecular mechanisms that

provide a more detailed understanding of how the normally benign Dr.

Jekyll-like fungus known as Candida albicans transforms into a serious and

often life-threatening Mr. Hyde-like form.

C. albicans can cause serious and potentially life-threatening infections in

the mouth, blood and other tissues of people who are undergoing cancer

chemotherapy or radiation treatments, or who have developed AIDS or other

diseases that damage the immunity of the individual.

In two separate papers recently published in Developmental Cell and the EMBO

journal, the team of scientists led by Wang Yue, principal investigator at

IMCB, have managed to reveal previously unknown mechanisms which are

responsible for causing the infectious phase of C. albicans.

The fungus starts its 'attack' on a patient by changing its oval shape into

a filamentous form, which has thin, threadlike appendages emerging from the

cell body. Wang's team, who has been studying C. albicans for more than

seven years, was responsible for identifying the master " controller " protein

called Hgc1 in 2004.

This " controller " functions like a regulator and tells the fungus when to

start the transformation from the harmless oval shape to the infectious

filamentous form.

" One question remained, however - how does it activate the cellular

machineries that determine the fungal cell shape? " said Wang.

Wang's team found the answer to this question in two proteins called Rga2

and Cdc11. They discovered that they each function like a switch on two

different cellular machineries that normally determines cell shape. " The

master regulator Hgc1 acts like the 'finger' that flips the switches to

start the infection process, " said Wang.

" Our findings have uncovered detailed molecular mechanisms which define how

these two proteins interact with the master 'controller' to cause

infections. This has opened new opportunities for us to investigate further

into a new range of therapeutic targets for fungal infections, " explained

Wang.

In the same issue of Developmental Cell, the team's work was given an expert

mention by a leading C. albicans researcher, Dr. Sudbery, stating its

importance in bringing awareness of the cellular processes that is necessary

for C. albicans to transform to its infectious state.

In addition, the new knowledge of the detailed interaction of these proteins

with other cellular machineries has also revealed critical information on

how cells in general determine their shape, a fundamental question in

biology as Rga2 and Cdc11 are also found in nearly all eukaryotic organisms.

Largely due to the AIDS pandemic in the last 25 years, the once nearly

harmless and commensal fungus Candida albicans has become one of the most

prevalent microbial pathogens in AIDS patients, causing life-threatening

infections with high death rate, especially in infected children.

References: XD Zheng, RTH Lee, YM Wang, QS Lin, and Y Wang. Phosphorylation

of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal

growth. The EMBO Journal 26, 3760-3769 (2007).

I Sinha, YM Wang, R Philp, CR Li, WH Yap, and Y Wang Cyclin-Dependent

Kinases Control Septin Phosphorylation in Candida albicans Hyphal

Development. Developmental Cell 13: 421-432 (2007).

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Best of Health!

Dr. Saul Pressman

[Guest guest]

Hi Folks,

As I am going onto the anti candida diet as from Monday I have been doing a bit

of research on the tinternet and came across a couple of good sites:

This is a quote from one which contains some research about anti fungals, both

natural and chemical. Is says that candida can cause muscle and joint pain which

maybe explains my right side pain. This site is really good and talks about t3/

t4 combo treatment etc.

" They would appear to be simply covering their backs in the absence of what they

would call " definitive " proof. The suggestion that they accept substantial yeast

overgrowth but not the production of toxins seems ridiculous. The major products

of normal yeast metabolism (ethanol and acetaldehyde) are well known toxins that

cause serious damage to living tissue. With this in mind, an increase in yeast

colonization will undoubtedly lead to an increase in production of toxins and at

some point, disease as a result. "

I think it says one or other of these chemicals can interfere with t3.

http://www.ei-resource.org/ Environmental Illness Resource

THIS IS HELPFUL ADVICE TO EASE THE DIE OFF, I DO REALISE THE EXERCISE BIT IS NOT

POSSIBLE FOR A LOT OF MEMBERS.

`Through experimentation, I've found the following to be really helpful with

detoxing:

· If the candida flush that day is intense and this shows up in the skin on my

hands and face, I take a couple tablets of caprylic acid.

· Raising my body temperature also really helps. When snowshoeing I work up a

deep and long sweat and that day I glide through the day without candida release

symptoms. Any intense and vigorous aerobic exercise also helps kill off the

released candida. Hot yoga and far infrared saunas also are great.

· If the candida release is really tough that day, I may take ¼ tsp. Or so

baking soda in a glass of water.

· The candida release is way more uncomfortable if I eat white and fluffy

starches, caffeine, or too much sugar that day so you may want to avoid those.'

http://www.lucybeale.com/wellness/candida%20protocol.htm 15/05/2009

IT LOOKS LIKE I MAY HAVE TO GIVE UP COFFEE!

Love Ali xx xx