Goiter Without Iodine Deficiency Abstract

[Guest guest]

Kentucky Appalachian Goiter Without Iodine Deficiency

Evidence for Evanescent Thyroiditis

Dorothy R. Hollingsworth, MD; Lawrence K. Butcher, MD; D. White, MD

Am J Dis Child. 1977;131(8):866-869.

Abstract

• In Breathitt County, Kentucky, an Appalachian Mountain community, 1,267

children were examined to determine goiter prevalence. Matched pairs of 82

goitrous and nongoitrous children were reexamined six months later for family

history, urinary iodine excretion, serum thyroxine, triiodothyronine,

protein-bound iodine, thyrotropin, and thyroid autoantibodies. Goiter prevalence

was 8.4%. Iodine deficiency was not found. Thyroid stimulating hormone levels

were higher in the goitrous group. Microsomal autoantibody titers were elevated

in 20% of the children with goiters vs 6% of controls (P <.05). Fluorescent

antibodies were associated with positive microsomal (P <.01) but not with

positive tanned RBC autoantibodies. Unexpectedly, on repeat examination, goiter

was absent in 17 (21%) of the originally goitrous group, but was now present in

22 (25%) of the controls. We concluded that while evolving thyroiditis is common

in Appalachian children, it does not explain all goiters in an area of abundant

iodine intake and known familial goiter.

(Am J Dis Child 131:866-869, 1977)

Author Affiliations

From the Department of Pediatrics, University of Kentucky College of Medicine,

Lexington.

Footnotes

Reprint requests to Department of Pediatrics, University of Kentucky Medical

Center, Lexington, KY 40506 (Dr Hollingsworth).

http://archpedi.ama-assn.org/cgi/content/abstract/131/8/866?maxtoshow= & HITS=10 & h\

its=10 & RESULTFORMAT= & fulltext=iodine & searchid=1 & FIRSTINDEX=0 & resourcetype=HWCIT

[Guest guest]

Thanks for the posting. I guess they did not use the testing method Abraham

established for determining iodine sufficiency, no wonder they found no

deficiency(How should they, that study is from 1977! ).

>

>

> Kentucky Appalachian Goiter Without Iodine Deficiency

> Evidence for Evanescent Thyroiditis

>

>

> Dorothy R. Hollingsworth, MD; Lawrence K. Butcher, MD; D. White, MD

> Am J Dis Child. 1977;131(8):866-869.

>

> Abstract

>

> • In Breathitt County, Kentucky, an Appalachian Mountain community, 1,267

children were examined to determine goiter prevalence. Matched pairs of 82

goitrous and nongoitrous children were reexamined six months later for family

history, urinary iodine excretion, serum thyroxine, triiodothyronine,

protein-bound iodine, thyrotropin, and thyroid autoantibodies. Goiter prevalence

was 8.4%. Iodine deficiency was not found. Thyroid stimulating hormone levels

were higher in the goitrous group. Microsomal autoantibody titers were elevated

in 20% of the children with goiters vs 6% of controls (P <.05). Fluorescent

antibodies were associated with positive microsomal (P <.01) but not with

positive tanned RBC autoantibodies. Unexpectedly, on repeat examination, goiter

was absent in 17 (21%) of the originally goitrous group, but was now present in

22 (25%) of the controls. We concluded that while evolving thyroiditis is common

in Appalachian children, it does not explain all goiters in an area of abundant

iodine intake and known familial goiter.

>

> (Am J Dis Child 131:866-869, 1977)

>

> Author Affiliations

>

> From the Department of Pediatrics, University of Kentucky College of Medicine,

Lexington.

>

> Footnotes

>

> Reprint requests to Department of Pediatrics, University of Kentucky Medical

Center, Lexington, KY 40506 (Dr Hollingsworth).

>

>

http://archpedi.ama-assn.org/cgi/content/abstract/131/8/866?maxtoshow= & HITS=10 & h\

its=10 & RESULTFORMAT= & fulltext=iodine & searchid=1 & FIRSTINDEX=0 & resourcetype=HWCIT

>