Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 Hi Everybody Can anyone help me to find out if there is a connection between hypothyroid disease and the liver disease called gilbert's syndrome? My 19yr old son has been diagnosed with gilberts syndrome whilst on his gap year, luckily he happened to be in new zealand when he was admitted to hospital with vomiting and diorhea and he had to have 3 bags of fluid to rehydrate him. The medics are apparently very good there. He had blood tests done and they found out his liver is not working properly and that it is a genetic fault passed on by both parents. The funny thing is when I looked up the symptoms they are identical to the hypothyroid ones, and it said that lots of people with it are diagnosed as CF. Both myself and my husband are now diagnosed as hypothyroid, and I was convinced that my son also had the same problem as he has lots of the symptoms. I was going to get him tested on his return, which I still will do I think. The question I want to ask though is it common for hypothyroid patients to have this syndrome, and is that the cause of hypothyroidism in some people? love janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 Hi Janet, Im very interested in your post as we came to the conclusion that my son (33) has Gilberts - he had lots of bloods done that showed nothing other than raised bilirubin and slightly raised cholesterol - but the info Ive read says that they also have a lowered risk of heart conditions. As Im hypoT Im wondering now if there is a connection so will be interested if you find anything and I will look into it myself too! Gill Can anyone help me to find out if there is a connection between hypothyroid disease and the liver disease called gilbert's syndrome?The question I want to ask though is it common for hypothyroid patients to have this syndrome, and is that the cause of hypothyroidism in some people? Internal Virus Database is out-of-date.Checked by AVG Free Edition. Version: 7.5.516 / Virus Database: 269.17.6/1192 - Release Date: 21/12/07 13:17 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 ....this is from another group: Bill ~~~~~~~ From: Nicola NaturalThyroidHormonesADRENALS Date: Mon, 17 Sep 2007 07:45:08 +0000 [...] I have Gilberts Syndrome! It is diagnosed by elevated serum bilirubin with otherwise normal LFTs. It is apparently a genetic shortage of an enzyme which breaks down bilirubin in the glucoronidation process of the phase 2 liver pathway. Because the bilirubin is not being broken down as fast as it should, it leads to a build-up of bilirubin in the blood, and can cause sufferers to look jaundiced, with yellow skin and eyes. Doctors claim Gilberts is benign, but it is not! They have not appreciated that if one function of the liver is working slowly, then probably the whole phase 2 pathway of the liver is working slowly. There is a direct link between Gilberts syndrome and hypothyroidism, because the conversion of T4 to T3 occurs in the phase 2 pathway of the liver. Other things like steroid synthesis, utilisation of Vits D and K, methylation also take place in phase 2, and are all likely affected by the slow functioning of this pathway. Gilberts syndrome sufferers are 4 times more likely to suffer from chronic fatigue than 'normal' people -- quite simply, their livers cannot keep up with the weight of detoxification. Doctors say that Gilberts is genetic, ie inherited. Not true!! No-one else in my family has Gilberts -- they have been tested. Gilberts can be 'acquired' by years' exposure to heavy metals, ie mercury, which get detoxed from the body via the phase 2 pathway. The mercury damages the phase 2, and voila, you've got Gilberts! At least, this is the only liver function affected that shows up on standard blood tests. I am sure if doctors were to test methylation, Vit D,K synthesis, conversion of T4 to T4, then this would all show up as slow. But that would be asking too much of our well-paid medical profession. We patients have been left to find these things out by ourselves!!! So, if you have Gilberts, you will have elevated bilirubin and normal LFTs in a blood test. You will unlikely convert T4 to T3 well, and will probably do better on T3 only. You will likely have blood sugar problems (sluggish liver), and need supplementary Vits D and K. You will probably have bloating, some nausea (when symptoms are accute), brain fog, fatigue, irritability. The liver and adrenals work very closely together to maintain blood sugar, and, because the liver is sluggish, you will likely have blood sugar problems or carb intolerance too. Loads more info here: www.gilbertssyndrome.com How's that for a Monday morning lesson?! best Nicola ------- NaturalThyroidHormonesADRENALS/ --- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 6, 2009 Report Share Posted March 6, 2009 Brilliant Bill - many thanks for sharing this with us. Luv - Sheila ....this is from another group: Bill So, if you have Gilberts, you will have elevated bilirubin and normal LFTs in a blood test. You will unlikely convert T4 to T3 well, and will probably do better on T3 only. You will likely have blood sugar problems (sluggish liver), and need supplementary Vits D and K. You will probably have bloating, some nausea (when symptoms are accute), brain fog, fatigue, irritability. The liver and adrenals work very closely together to maintain blood sugar, and, because the liver is sluggish, you will likely have blood sugar problems or carb intolerance too. Loads more info here: www.gilbertssyndrome.com How's that for a Monday morning lesson?! best Nicola ------- NaturalThyroidHormonesADRENALS/ --- Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2009 Report Share Posted March 7, 2009 > > > > Dear Bill > > Thank you so much for this, I have been searching for a connection and have found that the bilirubin is affected by hypothyroidism, I think this is another of the things like CFS or fibromyalgia that is a neglected part of the thyroid 'family' love janet Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2009 Report Share Posted August 8, 2009 Hi janet toxic load of mercury can cause problems for the thyroid. Have a look at the information that we have on our website re 'mercury' under 'Associated Conditions http://www.tpa-uk.org.uk/mercury.php .. People with amalgam fillings in particular should get tested to see what level mercury they have in their blood. Luv - Sheila Has anybody got any information about any studies that have been done on this, as I would be really interested. Of course the official take on it is that the condition is benign and people with it have no difficulties at all. It is not what the support groups think though. No virus found in this incoming message. Checked by AVG - www.avg.com Version: 8.5.392 / Virus Database: 270.13.45/2286 - Release Date: 08/07/09 18:37:00 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2009 Report Share Posted August 8, 2009 http://www.genecards.org/cgi-bin/carddisp.pl?gene=Dio3 Function: Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development ** If either of these two 'inactive' metabolites build up ~ degradation to 3-iodothyronamine will reverse the activity of T3 itself; this is proven science (Scanlan,T et al) 3-iodothyronamine is an amine and is transported in a different manner from that of T3. There is no excuse for either not knowing or minimising the damage that is being done through low T4 and/or low T3. Look at the mechanism for degradation and it's clear why both of them will be low. Hemangiomas arise from endothelial tissue ~ on the skin surface they disappear from birth onwards; appears they persist in the liver....for some reason..... [[...If it could be a cause of reduced T3 conversion then perhaps the condition your son has might. You could try googling gilbert's syndrome and thyroid and see what comes up....]] not reduced conversion as such, but increased degradation Bob >> I have a haemangioma on my liver. They discovered this accidentally some years ago whilst I was having a scan for something else. Since I stopped converting to T3, and as T3 is mainly converted in the liver, I thought I would look it up. > > I found:-> High levels of type 3 iodothyronine deiodinase activity were found in the haemangioma tissue. This enzyme is involved in the inactivation of thyroxine.> > As I was not quite sure what this means I did ask on the group if anyone could enlighten me, but as yet nobody has replied. > > If it could be a cause of reduced T3 conversion then perhaps the condition your son has might. You could try googling gilbert's syndrome and thyroid and see what comes up. > > Lilian> > > A few months ago my son was diagnosed with gilbert's syndrome whilst he was away in New Zealand. This is a liver condition ....> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 8, 2009 Report Share Posted August 8, 2009 Thanks Bob. Lilian not reduced conversion as such, but increased degradation Quote Link to comment Share on other sites More sharing options...
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