Guest guest Posted April 8, 2009 Report Share Posted April 8, 2009 Hi all, went for first endo appointment on mon pm..Bottom line of it was that he started me on levothyroxine 50mcg daily to be reviewed in a few months, and to go to GP for blood test in about 6 weeks. In true hypo fashion forgot to take list of symtpoms with me, but could remember a few, and rhymed them off, hair loss inc eyebrows, feeling cold, low energy, muscle weakness, dry skin, and DID remember to take Basal Temp results taken over 6 days, 4 days 36.1c , 35.9C once and 35.5 another, he wasn't least bit interested in these, and said symptoms none specific, although given TSH results that fluctuate quite wildy and TPO 150 ( although he said not really that bad ,given as he has seen ones in thousands, which I'm aware of reading other posts on the forum ), would put me on mild dosage of LT. He was pleasant overall, but could tell plays it safe. I've taken the first one today, and I don't know if it's because have had hectic week, but don't look or feel great..if it is med should I be feeling like this so quickly..? Thanks again Jill X Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2009 Report Share Posted April 8, 2009 Jill - don't expect to feel anything for a few weeks. For one thing, it takes thyroxine around 6 weeks to be fully absorbed. It also has to convert to the active thyroid hormone T3 which is does through the liver, kidneys and other thyroid receptor sites. You will have your thyroxine increased every six weeks to 2 months until you are on a level of thyroid hormone replacement that starts to make you feel better. You should take Selenium 200 mcgs daily (with food) and also 2/3000 mgs Vitamin C. It would be worth also taking 1000 Vitamin D3 daily too. Also check your zinc, magnesium and copper levels, plus ferritin and B12. If any of these are low, they will stop your thyroid hormone from being absorbed. Luv - Sheila TPO 150 ( although he said not really that bad ,given as he has seen ones in thousands, which I'm aware of reading other posts on the forum ), would put me on mild dosage of LT. He was pleasant overall, but could tell plays it safe. I've taken the first one today, and I don't know if it's because have had hectic week, but don't look or feel great..if it is med should I be feeling like this so quickly..? Thanks again Jill X No virus found in this incoming message. Checked by AVG - www.avg.com Version: 8.0.238 / Virus Database: 270.11.46/2046 - Release Date: 04/07/09 17:53:00 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2009 Report Share Posted April 8, 2009 thanks sheila, just wondering if there is any hard and fast rule or evidence to suggest what time of day this is best taken as patient info leaflet pretty useless... All I know to be taken on empty stomach at least an hour before food consumed. I adhered to this today, but was feeling pretty ropey soon afterwards, and now feeling very warm, ( like a flush ) . Just taken temp 36.7c, just in case was coming down with something as son under the weather. I do eat pretty late sometimes; 8/9;- due to husband working long hours and to give hime some company while he eats. Saw the gyno ( well her assistant who didn't listen and talked over me constantly ) yesterday as well re raised LH levels, and she said fine, as oestrogen levels back to normal, however still experiencing same pain as when had endometriosis , never even bothered giving me a physical or looking at blood tests results/medical noted in depth..??!! In thyroid treatment , " Sheila " <sheila@...> wrote: > > > It takes thyroxine around 6 weeks to be fully absorbed. It also has to convert > to the active thyroid hormone T3 which is does through the liver, kidneys > and other thyroid receptor sites. You will have your thyroxine increased > every six weeks to 2 months until you are on a level of thyroid hormone > replacement that starts to make you feel better. You should take Selenium > 200 mcgs daily (with food) and also 2/3000 mgs Vitamin C. It would be worth > also taking 1000 Vitamin D3 daily too. > > > > Luv - Sheila > > > > > TPO 150 ( although he said not really that bad ,given as he has seen ones in > thousands, which I'm aware of reading other posts on the forum ), would put > me on mild dosage of LT. He was pleasant overall, but could tell plays it > safe. > > I've taken the first one today, and I don't know if it's because have had > hectic week, but don't look or feel great..if it is med should I be feeling > like this so quickly..? > > Thanks again > Jill > X > > > > No virus found in this incoming message. > Checked by AVG - www.avg.com > Version: 8.0.238 / Virus Database: 270.11.46/2046 - Release Date: 04/07/09 > 17:53:00 > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 8, 2009 Report Share Posted April 8, 2009 Sheila, You wrote: > ... For one thing, it > takes thyroxine around 6 weeks to be fully absorbed.... Could you please explain what you mean by this. Thyroxine is quite fully absorbed in about an hour. What takes six weeks, is for it to reach " steady state " levels in the blood. The dose we are prescribed is a " maintenance " dose. It keeps our serum T4 at the required level. However, since it is only a fraction of what is stored in the blood, it takes about six weeks for the maintenance dose to build up to the serum levels that it is supposed to maintain. This is very different from absorption. Chuck Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 9, 2009 Report Share Posted April 9, 2009 Thanks for explaining Chuck. Luv - Sheila Sheila, You wrote: > ... For one thing, it > takes thyroxine around 6 weeks to be fully absorbed.... Could you please explain what you mean by this. Thyroxine is quite fully absorbed in about an hour. What takes six weeks, is for it to reach " steady state " levels in the blood. The dose we are prescribed is a " maintenance " dose. It keeps our serum T4 at the required level. However, since it is only a fraction of what is stored in the blood, it takes about six weeks for the maintenance dose to build up to the serum levels that it is supposed to maintain. This is very different from absorption. Chuck No virus found in this incoming message. Checked by AVG - www.avg.com Version: 8.0.238 / Virus Database: 270.11.46/2046 - Release Date: 04/07/09 17:53:00 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 11, 2009 Report Share Posted April 11, 2009 Hi Jill, If you have been prescribed levothyroxine ( T4) it will take at least 25 days for the dose you have been prescribed to stabilise as it has a half life of 5 days. I would'nt have thought that you would notice any difference for at least a couple of weeks, but then we don't all react the same. At least you have made a start. If at the 6 weeks stage you don't feel any better push for a dose increase then. Did he give you forms for free prescriptions? you are entitled now you have been diagnoses with hypo. Subject: Any advice/info..? Hi all, went for first endo appointment on mon pm..Bottom line of it was that he started me on levothyroxine 50mcg daily to be reviewed in a few months, and to go to GP for blood test in about 6 weeks. I've taken the first one today, and I don't know if it's because have had hectic week, but don't look or feel great..if it is med should I be feeling like this so quickly..? Thanks again Jill X ------------------------------------ TPA is not medically qualified. Consult with a qualified medical practitioner before changing medication. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 11, 2009 Report Share Posted April 11, 2009 , You wrote: > > If you have been prescribed levothyroxine ( T4) it will take at > least 25 days for the dose you have been prescribed to stabilise as it > has a half life of 5 days.... Technically the half life varies with thyroid state. If you are euthyroid, it is closer to 7 days. For someone who is hypoT, just starting the titration, it is even longer, up to 9 days. To reach the steady state serum level, it really takes at least 10 half lives, but 6 weeks, as you said, is close enough for a dosage increase. A clever doctor should be able to look at the blood test at 6 weeks (or even a little less) and predict what further increase is needed for a full dose. Chuck Quote Link to comment Share on other sites More sharing options...
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