Guest guest Posted May 6, 2009 Report Share Posted May 6, 2009 Well it was just interesting that is was the only thing that worked with my mum. She is 70 and is always happy to take whatever the Drs prescrible for quick fix. I certainly wasn't happy & told her so. I wonder what other options might have been? Not much I guess. I will keep this information in case the situation comes up again. Thanks. Adrienne. > > > > Ok, I got a response from Dr. Brownstein. His words were: BIG BIG Risks. Dangerous Drug. Associated with a Ton of bad things. " This is " No way to get Iodine. > > > > So if you think it is better than no iodine at all. Think again. You would be better off w/o both if you only have the option of Amiodarone. > > > > > > > > > > This is from the PDR: > > > > > > > > CORDARONE RX > > Amiodarone HCl (Wyeth) > > > > THERAPEUTIC CLASS > > Class III antiarrhythmic > > > > INDICATIONS > > Back to top > > Treatment of documented, life-threatening recurrent ventricular fibrillation and recurrent hemodynamically unstable ventricular tachycardia. > > > > ADULT DOSAGE > > Back to top > > Adults: Give LD in hospital. LD: 800-1600mg/day in divided doses for 1-3 weeks. After control is achieved, then 600-800mg/day for 1 month. Maint: 400mg/day; up to 600mg/day if needed. Use lowest effective dose. Take with meals. Elderly: Start at low end of dosing range. > > > > HOW SUPPLIED > > Back to top > > Tab: 200mg* *scored > > > > CONTRAINDICATIONS > > Back to top > > Severe sinus-node dysfunction causing marked sinus bradycardia; 2nd- and 3rd-degree AV block; when episodes of bradycardia have caused syncope (except when used with a pacemaker); cardiogenic shock. Hypersensitivity to iodine. > > > > WARNINGS/PRECAUTIONS > > Back to top > > Only for life-threatening arrhythmias due to its substantial toxicity (eg, pulmonary toxicity including pulmonary alveolar hemorrhage, hepatic injury, arrhythmia exacerbation). Hospitalize when giving LD. May cause a clinical syndrome of cough and progressive dyspnea. D/C if LFTs are 3x ULN or if elevated baseline doubles; monitor LFTs regularly. Optic neuropathy, optic neuritis reported. Fetal harm in pregnancy. May develop reversible corneal micro deposits (eg, visual halos, blurred vision), photosensitivity, peripheral neuropathy (rare). May decrease T3 levels, increase thyroxine levels, increase inactive reverse T3 levels and can cause hypo- or hyperthyroidism. Hyperthyroidism may result in thyrotoxicosis and/or the possibility of arrhythmia breakthrough or aggravation. ARDS reported with surgery. Correct K+ or magnesium deficiency before therapy. Caution in elderly. > > > > ADVERSE REACTIONS > > Back to top > > Pulmonary toxicity (eg, inflammation, fibrosis), arrhythmia exacerbation, hepatic injury, malaise, fatigue, tremor, poor coordination, paresthesis, nausea, vomiting, constipation, anorexia, ophthalmic abnormalities, photosensitivity, akinesia, bradykinesia. > > > > DRUG INTERACTIONS > > Back to top > > Risk of interactions after discontinuation due to its long half-life. May increase sensitivity to myocardial depressant and conduction effects of halogenated inhalation anesthetics. Elevates cyclosporine plasma levels. D/C or reduce digoxin dose by 50%. D/C or decrease warfarin dose by 1/3-1/2. Avoid grapefruit juice. Caution with ?-blockers, CCBs, lidocaine, methotrexate. May increase levels of quinidine, procainamide, phenytoin, flecainide. Initiate added antiarrhythmic drug at lower than usual dose. D/C or decrease quinidine dose by 1/3-1/2. D/C or decrease procainamide dose by 1/3. Caution with loratadine, trazadone, disopyramide, fluoroquinolones, macrolides, azoles; QT prolongation reported. Decreased levels with cholestyramine, rifampin, phenytoin, St. 's wort. Rhabdomyolysis/myopathy reported with HMG-CoA reductase inhibitors (simvastatin and atorvastatin). Ineffective inhibition of platelet aggregation with clopidogrel. Fentanyl may cause hypotension, bradycardia, and decreased cardiac output. Increased levels with protease inhibitors; monitor for toxicity. Increased levels of CYP1A2, CYP2C9, CYP2D6, CYP3A4 substrates reported. Interactions reported with CYP3A4 inducers. CYP2C8 and CYP3A4 inhibitors may increase amiodarone levels. > > > > PREGNANCY > > Back to top > > Category D, not for use in nursing. > > > > MECHANISM OF ACTION > > Back to top > > Class III antiarrhythmic; prolongs myocardial cell-action potential duration and refractory period, and causes noncompetitive ?- and ?-adrenergic inhibition. > > > > PHARMACOKINETICS > > Back to top > > Absorption: Slow and variable; Tmax=3-7 hrs. Distribution: Vd=60L/kg; plasma protein binding (96%); found in breast milk. Metabolism: CYP3A4, 2C8; desethylamiodarone (major metabolite). Elimination: Bile, urine; T1/2=58 days, 36 days (metabolite). > > > > ASSESSMENT > > Back to top > > Assess for life threatening arrhythmias, ventricular arrhythmia, optic neuropathy or optic neuritis, hepatic impairment, pregnancy/nursing status, thyroid function, pre-exsisting pulmonary disease, recent MI, and possible drug interactions. Correct hypokalemia and hypomagnesemia prior to initiation. > > > > MONITORING > > Back to top > > Monitor for pulmonary toxicities (eg, hypersensitivity pneumonitis, or interstitial/alveolar pneumonitis) manifested by cough, progressive dyspnea, and fatalities, accompanied by functional, radiological, gallium-scan, and pathological data. Perform history, physical exam, and chest X-ray every 3-6 months. Monitor for sinus bradycardia, sinus arrest, and heart block. Monitor induced hyperthyroidism/thyrotoxicosis, hepatic failure, optic neuritis/neuropathy, corneal microdeposits, vision loss, fetal harm, peripheral neuropathy, photosensitivity, LFTs, T4, T3 and reverse T3. Perioperative monitoring for hypotension and ARDS recommended. > > > > PATIENT COUNSELING > > Back to top > > Advise to notify physician if pregnant/nursing. Inform about benefits/risks, including possibility of vision impairment, thyroid abnormalities, peripheral neuropathy, and photosensitivity. Report any adverse reactions to physician. Counsel to take as directed. Do not take with grapefruit juice. Avoid prolonged sunlight exposure. Advise that corneal refractive laser surgery is contraindicated with concurrent use. > > > > ADMINISTRATION/STORAGE > > Back to top > > Administration: Oral route. Storage: 20-25°C (68-77°F). Protect from light. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2009 Report Share Posted May 6, 2009 Hello perennialgardener2003, Wednesday, May 6, 2009, 4:24:20 AM, you wrote: > AF is NOT an " drug " insufficiency : ) > Traditional docs may choose to use drugs to treat many presentations > of AF, but that does not mean thats the way to treat it. > Personally, I think sometimes we've been so accustomed to thinking > modern medicine has ALL the answers that we don't look at what the > body is asking for, what it is lacking to function properly. Do you know the best way to treat atrial fibrillation without using drugs? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2009 Report Share Posted May 6, 2009 Try this http://www.herbchina2000.com/therapies/AFL.shtml Steph Re: Re: Amiodarone Hello perennialgardener2003,Wednesday, May 6, 2009, 4:24:20 AM, you wrote:> AF is NOT an "drug" insufficiency : ) > Traditional docs may choose to use drugs to treat many presentations> of AF, but that does not mean thats the way to treat it. > Personally, I think sometimes we've been so accustomed to thinking> modern medicine has ALL the answers that we don't look at what the> body is asking for, what it is lacking to function properly.Do you know the best way to treat atrial fibrillation without using drugs? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 6, 2009 Report Share Posted May 6, 2009 Mine got better on Armour. I kept trying to wean off Toprol while taking synthetic thyroid but was not able to. Had a premature heartbeat when I tried to get off it. Boy that will leave you exhausted. Doc said that it was normal to have a premature heartbeat but I know better than that. LOL Don't know if that will help or not. Have very few A-fibs on 4 1/2 grains of Armour and will be upping to 5 soon. Seems to be mostly when I'm really tired. Melody On Wed, May 6, 2009 at 1:16 PM, <t10a8d5r@...> wrote: > Hello perennialgardener2003, > > Wednesday, May 6, 2009, 4:24:20 AM, you wrote: > >> AF is NOT an " drug " insufficiency : ) > >> Traditional docs may choose to use drugs to treat many presentations >> of AF, but that does not mean thats the way to treat it. > >> Personally, I think sometimes we've been so accustomed to thinking >> modern medicine has ALL the answers that we don't look at what the >> body is asking for, what it is lacking to function properly. > > > Do you know the best way to treat atrial fibrillation without using drugs? > > > > > > > > ------------------------------------ > > > > > Quote Link to comment Share on other sites More sharing options...
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