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Dear friends

Dropout and discontinuation rates that are greater than anticipated threaten the successful completion of any clinical trial; anticipated dropout and discontinuation rates must be incorporated in sample size projections to determine the number of patients that should be recruited.

[Ref: Spilker B, Cramer J. Patient recruitment in clinical trials. Philadelphia, PA: Lippincott-Raven Publishers, 1996.]

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Tarun Wadhwa

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