Ethical Pharmacogenetics in CT

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Dear

members,

The advent of Pharmacogenetics and pharmacogenomics - the study of how the human

genome influences drug response within a person or population - has begun to

drive the development of pharmaceuticals in medicine today. Although

pharmacogenomics promises dramatic improvement in drug safety and efficacy, the

field also raises a host of ethical questions.

The need to protect

informed consent and confidentiality and to promote justice and equity - both

nationally and globally - requires that one approach pharmacogenetics with an

enthusiastic, yet critical, eye.

Before I start with the Ethics part in Pharmacogenetics,

let me explain the mechanism of pharmacogenetics in short.

Genetic factors in drug effects: -Due

to Variations in genes coding for drug

metabolizing enzymes, receptors and transporters, it may lead to altered Drug metabolism, Drug transport , Disease

susceptibility , Receptor

sensitivity , Adverse

Drug Reaction and Responders/

Non-responders

RegardsDr Sanjay Yallappa ChoudhariJR2,Dept of PharmacologyGMC, Nagpur

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