Effects of Chronic Lymphocytic Leukemia on the Development and Progression of Malignant Melanoma

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Effects of Chronic Lymphocytic Leukemia on the Development and Progression of

Malignant Melanoma.

JD Brewer, LJ Christenson, RH Weenig, and AL Weaver

Dermatol Surg, January 19, 2010; .

Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

BACKGROUND An association exists between chronic lymphocytic leukemia and

malignant melanoma. OBJECTIVES To study the clinical behavior of malignant

melanoma in patients with chronic lymphocytic leukemia. METHODS A retrospective

chart review was conducted of patients with chronic lymphocytic leukemia and

malignant melanoma. RESULTS Sixty-nine patients had malignant melanoma and

chronic lymphocytic leukemia. The recurrence-free and metastasis-free survival

rates at 2, 5, and 10 years were 93.4% and 89.1%, 83.8% and 93.4%, and 87.4% and

82.1%, respectively. No significant difference was observed in age- and

sex-adjusted mortality rates between patients with chronic lymphocytic leukemia

diagnosed before malignant melanoma and those with chronic lymphocytic leukemia

diagnosed after malignant melanoma. LIMITATIONS Retrospective study and small

patient population. CONCLUSION Patients with malignant melanoma and chronic

lymphocytic leukemia were not shown to have worse survival rates than those with

stage IA, IB, and IIA disease. Further research and prospective study are

needed. The authors have indicated no significant interest with commercial

supporters.

PMID: 20100262

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