The role of Bcl-2 family proteins in chronic lymphocytic leukaemia

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BlankThe role of Bcl-2 family proteins in chronic lymphocytic leukaemia.

AG Buggins and CJ Pepper

Leuk Res, March 30, 2010; .

Department of Haematological Medicine, King's College London, London, SE5 9NU,

UK.

Bcl-2 family proteins have long been implicated in the pathology of chronic

lymphocytic leukaemia (CLL). Indeed, a number of these proteins have been shown

to have prognostic importance in this disease. The precise ways in which these

proteins impact upon CLL and the ways in which they are regulated remain

incompletely resolved. However, significant advances have been recently made in

our understanding of how these proteins are controlled by genetic, epigenetic

and microenvironmental cues. Furthermore, major progress has been made in trying

to target these proteins therapeutically. Here we review the current knowledge

about this family of apoptosis-regulating proteins and how they impact upon drug

resistance and disease progression. We also summarise evolution in the

development of Bcl-2 family inhibitors for the treatment of CLL and other

cancers.

PMID: 20359747

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