Telomere length, molecular cytogenetic findings, and immunophenotypic features in previously untreated patients with B-chronic lymphocytic leukemia

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BlankTelomere length, molecular cytogenetic findings, and immunophenotypic

features in previously untreated patients with B-chronic lymphocytic leukemia.

J Brezinova, A Berkova, S Vcelikova, Z Zemanova, S Izakova, I Sarova, H Cechova,

J Tajtlova, L Grosova, L Lizcova, E Malinova, M Zemanova, E Cmunt, J Karban, M

Trneny, J Schwarz, and K Michalova

Neoplasma, January 1, 2010; 57(3): 215-21.

Telomere length was evaluated by terminal repeat fragment method in 66

previously untreated patients with B-chronic lymphocytic leukemia (B-CLL) to

ascertain whether telomere shortening was associated with genomic aberrations,

immunoglobulin variable heavy chain (IgVH) mutational status, CD38 and ZAP-70

expression, and telomerase activity. Chromosomal aberrations were present in

peripheral blood cells of 73% patients (48/66), no difference in telomere length

between patients with good and intermediate prognosis according to cytogenetics

was found. Association between telomere length and IgVH mutational status,

ZAP-70 and CD38 expression was proved as significantly shorter telomeres in

patients with unmutated IgVH status (p=0.01) and ZAP-70 positivity (p=0.01) and

CD38 positivity (p=0.05) were detected. Telomerase activity was positive in 11

patients out of 21 examined, correlation between telomere length and telomerase

activity was found (p=0.05). Telomere length and telomerase activity in

combination with other prognostic parameters complete the risk profile of B-CLL

patients and might serve for an easy decision on optimal treatment strategy.

PMID: 20353271

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