The Splenic White Pulp in Chronic Lymphocytic Leukaemia: A Microenvironment Associated with CR2 (CD21) Expression, Cell Transformation and Proliferation

[Guest guest]

BlankThe Splenic White Pulp in Chronic Lymphocytic Leukaemia: A Microenvironment

Associated with CR2 (CD21) Expression, Cell Transformation and Proliferation.

IA Lampert, U Hegde, and S Van Noorden

Leuk Lymphoma, January 1, 1990; 1(5-6): 319-26.

Department of Histopathology and Haematology, Royal Postgraduate Medical School,

DuCane Road, London, W12 OHS.

Splenectomy specimens from 8 cases of chronic lymphocytic leukaemia (CLL) were

examined. The infiltrate in the red pulp consisted predominantly of small

lymphocytes. In contrast the predominant cells in the white pulp were

pro-lymphocytes and para-immunoblasts. The Ki67 marker, which identifies cells

in growth phase, was also concentrated among the transformed cells in the white

pulp. Staining with monoclonal antibodies for CD21, which identifies the CR2

receptor, showed that the cells in the white pulp were strongly positive in

contrast to those in the red pulp which were weak or negative. These findings

suggest that factors present in the white pulp promote transformation and

proliferation of CLL cells.

PMID: 20394560

----------

No virus found in this outgoing message.

Checked by AVG - www.avg.com

Version: 8.5.437 / Virus Database: 271.1.1/2823 - Release Date: 04/20/10

12:45:00