DL-Derived octopus Antibodies

[Guest guest]

Early (preclinical) and interesting. I don't know who dreams up the

designation (names), but they need help! Octopus antibody works for me.

Karl

Immunomedics Presents New DNL-Derived Antibodies for Mantle Cell [CLL and

b-cell] lymphoma at AACR Annual Meeting

The Creation and Initial Characterization of a DNL-Derived Dendrimeric

Nanoparticles Also Presented

Designated as 74-(20)-(20) and 20-(74)-(74), the two DNL-engineered

antibodies each has six binding arms capable of attaching to two different

targets simultaneously. Specifically, 74-(20)-(20) is made up of 4

antigen-binding regions (Fabs) of veltuzumab, the Company's anti-CD20

humanized antibody, linked to an intact milatuzumab, the Company's anti-CD74

humanized antibody, while 20-(74)-(74) contains 4 Fabs of milatuzumab

conjugated to a veltuzumab.

The activity of the two anti-CD20/CD74 antibodies was evaluated on a panel

of cell lines and primary patient tumor samples. At a low concentration of

10 nM, the two DNL constructs potently inhibited the growth of MCL cells, as

well as chronic lymphocytic leukemia cells and non-Hodgkin's lymphoma cells,

without the need for crosslinking by a secondary antibody. Both antibodies

depleted B cells from whole blood, where only veltuzumab was effective under

the same conditions, but not milatuzumab. Hence, the bispecific antibodies

appeared to be more potent than a mixture of the parental antibodies

http://www.globenewswire.com/newsroom/news.html?d=217963

All the best,

~ Karl

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