resveratrol as cancer treatment?

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Concentration, Timing and Interactions Are Key When It Comes to Dietary

Compounds

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In an study of animals with sex-hormone-dependent tumor cells:

" First, Wang exposed human prostate cancer cells to resveratrol and found

that it inhibited the cells' growth. He further tested the cells' gene

expression. Then Wang tested the effects of resveratrol on a group of

laboratory animals that had sex-hormone-dependent tumor cells.

Half of those animals were fed a daily diet that included 3 to 6 milligrams

of purified resveratrol (equal to roughly the amount in five glasses of wine

or grape juice). At first, the tumor cells in the resveratrol-fed lab

animals grew slower. But as the animals continued to consume resveratrol,

there was an increase in blood vessels developing around the tumors of the

resveratrol-fed animals, effectively setting up a system of feeding the

tumors. "

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The above observation reminds us that caution and humility are needed,

because the affect in a cell culture does not predict the affect even in

animals - and at therapeutic doses in those small animals, the affect on

cancer cells could be undesirable.

As always, such findings are specific to, and limited to, the type of animal

and the type of cancer in that animal. As Bill writes: " A mice is not a

man, or a women. " http://www.lymphomation.org/mouse-model.htm

We all wish it was easier. Thankfully, there are many compounds that target

the epigenetic deregulation of lymphoma cells that are already in advanced

phases of testing in lymphoma patients and showing very encouraging clinical

activity and safety.

All the best,

~ Karl

Patients Against Lymphoma

Patients Helping Patients

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