Leukaemic mantle cell lymphoma with t(11;14) and trisomy 12 showing clinical features of state A0 B cell chronic lymphocytic leukaemia

[Guest guest]

Leukaemic mantle cell lymphoma with t(11;14) and trisomy 12 showing clinical

features of state A0 B cell chronic lymphocytic leukaemia.

J R Neilson, M Cai, N Bienz, and M J Leyland

Clin Mol Pathol, June 1, 1995; 48(3): M165-M166.

Department of Haematology, Birmingham Heartlands Hospital, Bordesley Green East,

Birmingham B9 5SS.

The precise diagnosis of lymphoma usually requires the histological examination

of lymph nodes or involved tissues. Mantle cell lymphoma is a form of

intermediate grade non-Hodgkin's lymphoma in which typical morphological

immunophenotypic and cytogenetic features have been recognised. A case of

leukaemic mantle cell lymphoma with the characteristic reciprocal translocation

t(11;14) together with trisomy 12, a chromosomal abnormality usually associated

with B cell chronic lymphocytic leukaemia (CLL), is presented. This combination

of cytogenetic abnormalities has not been reported previously. The lack of

lymphadenopathy and hepatosplenomegaly in this patient is more in keeping with

stage A0 CLL. This case demonstrates the close clinical and biological

relationship between mantle cell lymphoma and CLL.

PMID: 16695999