Carnosine!

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Histidine and carnosine delay diabetic deterioration in mice and

protect human low density lipoprotein against oxidation and glycation.

Lee YT, Hsu CC, Lin MH, Liu KS, Yin MC.

Department of Internal Medicine, Chungshan Medical University

Hospital, Taichung City, Taiwan, ROC.

In vivo effects of histidine and carnosine against diabetic

deterioration in diabetic Balb/cA mice were studied. Histidine and

carnosine at 0.5, 1 g/l were added into drinking water. After 4 weeks

intake of these agents, the content of histidine and carnosine in

plasma, heart and liver significantly elevated (P < 0.05). The intake

of these agents significantly decreased plasma glucose and fibronectin

levels (P < 0.05); however, only 1 g/l histidine and carnosine

treatments significantly increased insulin level (P < 0.05) in

diabetic mice. Triglyceride level in heart and liver was

dose-dependently reduced by histidine or carnosine treatments (P <

0.05); however, only 1 g/l histidine and carnosine treatments

significantly reduced cholesterol level in heart and liver (P < 0.05).

The administration of histidine or carnosine significantly enhanced

catalase activity and decreased lipid oxidation levels in kidney and

liver (P < 0.05); however, only 1 g/l histidine and carnosine

treatments significantly increased glutathione peroxidase activity (P

< 0.05). The increased interleukin (IL)-6 and tumor necrosis factor

(TNF)-alpha in diabetic mice were significantly suppressed by the

intake of histidine or carnosine (P < 0.05). In human low density

lipoprotein, histidine or carnosine showed dose-dependently

suppressive effect in glucose-induced oxidation and glycation (P <

0.05). These data suggest that histidine and carnosine are potential

multiple-protective agents for diabetic complications prevention or

therapy.

PMID: 15878720

Carnosine as a potential anti-senescence drug.

Gallant S, Semyonova M, Yuneva M.

Zoetic Neurosciences Ltd., Leighton Buzzard, Beds, LU7 7NW, Great

Britain. steven.gallant@....

The naturally occurring dipeptide carnosine (beta-alanyl-L-histidine)

has been found to exert an anti-senescence effect when used as a

dietary supplement. Carnosine clearly improved the external appearance

of experimental animals and provided beneficial physiological effects,

thus maintaining the animals in better condition than control animals

receiving no carnosine or a mixture of beta-alanine and L-histidine.

PMID: 10951107