Trisomy 8 as sole cytogenetic abnormality in a case of chronic lymphocytic leukemia

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BlankTrisomy 8 as sole cytogenetic abnormality in a case of chronic lymphocytic

leukemia.

LC Lau, SK Kee, SL Tien, and BC Koh Mickey

Cancer Genet Cytogenet, January 1, 2007; 172(1): 66-9.

Department of Pathology, Singapore General Hospital, Outram Road,

Singapore 169608.

A 49-year-old man, who had been diagnosed with chronic lymphocytic

leukemia (CLL) in 2002, had a normal karyotype in his bone marrow. Trisomy 8 was

demonstrated in his peripheral blood in 2005. Fluorescence in situ hybridization

using an LSI CEP 8 probe performed on the archival bone marrow specimen showed

three hybridization signals in 40% of 200 interphase cells scored. This

confirmed that the trisomy 8 abnormality was present in both the blood and bone

marrow samples. Trisomy 8 as the sole chromosomal abnormality in CLL is a very

rare finding. The prognostic significance of trisomy 8 in CLL remains to be

seen.